Results 1 to 10 of about 1,122,144 (148)

A trimeric spike-based COVID-19 vaccine candidate induces broad neutralization against SARS-CoV-2 variants

Human Vaccines & Immunotherapeutics, 2023
COVID-19 pandemic caused by SARS-CoV-2 infection has an impact on global public health and social economy. The emerging immune escape of SARS-CoV-2 variants pose great challenges to the development of vaccines based on original strains.
Feixia Gao, Mei Zheng, Jiangfeng Fan, Yahong Ding, Xueying Liu, Min Zhang, Xin Zhang, Jinrong Dong, Xu Zhou, Jian Luo, Xiuling Li   +10 more
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Cross-reactive immune responses to monkeypox virus induced by MVA vaccination in mice

Virology Journal, 2023
Mpox (monkeypox) infection cases increased recently in non-Mpox outbreak areas, potentially causing an international threat. The desire to defend against a potential outbreak has led to renewed efforts to develop Mpox vaccines.
Feixia Gao, Cheng He, Min Liu, Ping Yuan, Shihua Tian, Mei Zheng, Linya Zhang, Xu Zhou, Fangjingwei Xu, Jian Luo, Xiuling Li   +10 more
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Safety and immunogenicity of a combined DTacP-sIPV-Hib vaccine in animal models

Human Vaccines & Immunotherapeutics, 2022
The DTacP-sIPV-Hib combination vaccine can replace the single-component acellular pertussis, diphtheria, tetanus, polio, and Haemophilus influenzae type B vaccines. In this study, we evaluated the safety and immunogenicity of a newly developed DTacP-sIPV-
Yuntao Zhang, Yancen Guo, Yuan Dong, Yingwei Liu, Yuxiu Zhao, Shouzhi Yu, Shihui Li, Chongyang Wu, Baifeng Yang, Wanli Li, Xiaoli Wei, Yadan Zhang, Yunchao Huang, Hui Wang, Xiaoming Yang   +14 more
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Enhancing Inactivated Yellow Fever 17D Vaccine-Induced Immune Responses in Balb/C Mice Using Alum/CpG

Vaccines, 2023
There are some concerns about the safety of live attenuated yellow fever vaccines (YF–live), particularly viscerotropic adverse events, which have a high mortality rate.
Yadan Zhang, Rong Yang, Guangying Yuan, Weidong Li, Zihao Cui, Zhuangzhuang Xiao, Xiaofei Dong, Hongqiang Yang, Xiaojuan Liu, Le Zhang, Yirong Hou, Manyu Liu, Sushi Liu, Yu Hao, Yuntao Zhang, Xiaotong Zheng   +15 more
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AddaVax-Adjuvanted H5N8 Inactivated Vaccine Induces Robust Humoral Immune Response against Different Clades of H5 Viruses

Vaccines, 2022
Since some cases of human infections with H5N8 avian influenza virus have been reported and caused great concern in recent years, it is important to develop an effective vaccine for human use to prevent a potential H5N8 pandemic.
Feixia Gao, Xueying Liu, Yudong Dang, Peng Duan, Wenting Xu, Xin Zhang, Shilei Wang, Jian Luo, Xiuling Li   +8 more
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Comparative multiomics analysis of cell physiological state after culture in a basket bioreactor

Scientific Reports, 2022
Bioreactors are one of the most important, basic pieces of equipment in the biopharmaceutical industry. Understanding the effects of mechanical damage and other factors on the physiological state of cells during cell matrix culture is the basis for ...
Shouzhi Yu, Miaomiao Guo, Yadan Zhang, Cunpei Bo, Hongyang Liang, Hui Wang, Xiaoming Yang   +6 more
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A multicenter phase Ⅲ clinical study of human prothrombin complex concentrate in treatment of hemophilia B

Zhongguo shuxue zazhi, 2022
Objective To evaluate the clinical efficacy and safety of one kind of human prothrombin complex concentrate in treatment of patients with hemophilia B.
Wei ZHANG, Yirun LIU, Yan WU, Xuanlin ZHONG, Qingshuang SONG, Shitao CHEN, Xueyun WANG, Caiping GUO, Zhan ZHANG, Yunjia ZHANG   +9 more
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Emergence of a novel recombinant of CV-A5 in HFMD epidemics in Xiangyang, China

BMC Medical Genomics, 2021
Background Hand, foot and mouth disease (HFMD) is caused by a variety of enterovirus serotypes and the etiological spectrum worldwide has changed since a large scale of outbreaks occurred in 1997.
Yuting Yu, Zhiyu Luo, Weiping Jin, Jianyi Mai, Shasha Qian, Jia Lu, Zhenni Wei, Shengli Meng, Zejun Wang, Xuhua Guan, Yeqing Tong, Shuo Shen   +11 more
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Alum/CpG Adjuvanted Inactivated COVID-19 Vaccine with Protective Efficacy against SARS-CoV-2 and Variants

Vaccines, 2022
Since the beginning of the COVID-19 pandemic, numerous variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged, including five variants of concern (VOC) strains listed by the WHO: Alpha, Beta, Gamma, Delta and Omicron ...
Yuntao Zhang, Xiaotong Zheng, Wang Sheng, Hongyang Liang, Yuxiu Zhao, Xiujuan Zhu, Rong Yang, Yadan Zhang, Xiaofei Dong, Weidong Li, Fei Pei, Ling Ding, Zhen Chang, Li Deng, Guangying Yuan, Zhaona Yang, Di Zhu, Xiaoming Yang, Hui Wang   +18 more
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Study on the change of neutralizing antibody level in plasma donors after a third shot of inactivated novel coronavirus vaccine

Zhongguo shuxue zazhi, 2023
Objective To investigate the trend of neutralizing antibody level in plasma donors who received the 3rd shot of inactivated novel coronavirus vaccine.
Wenjuan GE, An ZHOU, Junying SHEN, Xiaoqing LI, Jie MA, Mengzhao ZHU, Changyong JIAN   +6 more
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