Results 111 to 120 of about 1,240,733 (309)

Physicochemical and biological similarity assessment of LBAL, a biosimilar to adalimumab reference product (Humira®)

, 2021
Joon-Cheol Kwon, Oh-Seok Kwon, Rae Ung Jeong, Nayoun Kim, Seonah Song, Ilsub Choi, Juneok Lee, Takahiko Horiuchi   +7 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Outbreak of occupational Brucella infection caused by live attenuated Brucella vaccine in a biological products company in Chongqing, China, 2020. [PDF]

Emerg Microbes Infect, 2022
Zhou C, Huang W, Xiang X, Qiu J, Xiao D, Yao N, Shu Q, Zhou S.   +7 more
europepmc   +1 more source

DEPENDENCE BETWEEN THEANTIMICROBIAL ACTIVITY AND THE MOLECULAR STRUCTURE OF PHENOLIC ACIDS AND THEIR SALTS WITHALKALI METALS AS BIOLOGICALLY ACTIVE SUBSTANCES PRESENT IN THE NATURAL PRODUCTS

, 2020
Jolanta Piekut, Małgorzata Kowczyk-Sadowy, Małgorzata Krasowska   +2 more
openalex   +1 more source

Effects of Switching to a Heat-Not-Burn Tobacco Product on Biologically Relevant Biomarkers to Assess a Candidate Modified Risk Tobacco Product: A Randomized Trial [PDF]

, 2019
Frank Lüdicke, Sam Ansari, Nicola Lama, Nicolas Blanc, Marija Bosilkovska, Andrea Donelli, Patrick Picavet, Gizelle Baker, Christelle Haziza, Manuel C. Peitsch, Rolf Weitkunat   +10 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Virome Characterization in Commercial Bovine Serum Batches-A Potentially Needed Testing Strategy for Biological Products. [PDF]

Viruses, 2021
Paim WP, Maggioli MF, Falkenberg SM, Ramachandran A, Weber MN, Canal CW, Bauermann FV.   +6 more
europepmc   +1 more source

Outlining the Potential Role of Humic Products in Modifying Biological Properties of the Soil—A Review [PDF]

, 2019
Mariia Pukalchik, Kamila Kydralieva, Olga Yakimenko, Е. В. Федосеева, В. А. Терехова   +4 more
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Biosafety Analysis of Metabolites of Streptomyces tauricus Strain 19/97 M, Promising for the Production of Biological Products. [PDF]

Bioengineering (Basel), 2022
Gaidasheva II, Shashkova TL, Orlovskaya IA, Gromovykh TI.   +3 more
europepmc   +1 more source