Results 141 to 150 of about 1,399,233 (310)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Endophytic bacteria and biological control of nematodes

, 2004
Endophytic bacteria colonize the internal host tissue as do sedentary endoparasitic nematodes, which makes them potential candidates for biological control of nematodes.
Sikora, Richard Alexander, Berg, Gabriele, Faupel, Annekathrin, Hallmann, Johannes, Krechel, Annette   +4 more
core  

Topical Chemical Space Relation to Biological Space

, 2010
In this chapter, the mapping of physical–chemical descriptor space of natural products and its relation to the biological space, with emphasis on evolutionary and topical biological space, is discussed.
Anders Backlund, Backlund, Anders,
core   +1 more source

Evaluation of Safety and Immunogenicity of High-Dose Quadrivalent Seasonal Influenza Split Vaccine: A Preclinical Study

Vaccines
Objectives: Seasonal influenza leads to substantial global morbidity and mortality, especially in adults aged 65 years and older, who present poor immune responses to standard-dose influenza vaccines.
Lanxin Jia, Ran Qiu, Jing Liu, Bo Liu, Xuanxuan Nian, Yang Le, Xixin Han, Qingmei Zhang, Xuedan Li, Zheng Gong, Ailin Shen, Zhegang Zhang, Ying Zhao, Jiayou Zhang   +13 more
doaj   +1 more source

Biosafety Analysis of Metabolites of Streptomyces tauricus Strain 19/97 M, Promising for the Production of Biological Products. [PDF]

Bioengineering (Basel), 2022
Gaidasheva II, Shashkova TL, Orlovskaya IA, Gromovykh TI.   +3 more
europepmc   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Comité de Expertos en Patrones Biol'ogicos [se reunió en Ginebra del 10 al 15 de diciembre de 1962] : 15 i̜nforme

, 1963
66 ...
WHO Expert Committee on Biological Standardization, World Health Organization   +1 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Recommendations for the Selection and Use of Respirators and Protective Clothing for Protection Against Biological Agents [2009-132]

"The approach to any potentially hazardous environment, including one with biological hazards, must be made with a plan that includes an assessment of hazard and exposure potential, respiratory protection needs, dermal protection needs, entry conditions,

core