Biological and biosimilar medicinal products: safety and efficacy
, 2016 Biological medicinal products are one of most innovative and promising methods of pharmacotherapy. During the last 20 years several original biological medicinal products have been registered and marketed. Their safety and efficacy have been investigated
Teresa Brodniewicz
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Real-world data: Assessing electronic health records and medical claims data to support regulatory decision-making for drug and biological products. [PDF]
Pharmacoepidemiol Drug Saf, 2022 Girman CJ, Ritchey ME, Lo Re V.
europepmc +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Investigation of the Behavioral Model of Suppliers of Raw Materials for Biological Products with a System Dynamics Approach (Case study: Razi Vaccine and Serum Research Institute). [PDF]
Arch Razi Inst, 2022 Seraji S, Mehrmanesh H, Kasraee AR.
europepmc +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Didecyldimethylammonium Chloride- and Polyhexamethylene Guanidine-Resistant Bacteria Isolated from Fecal Sludge and Their Potential Use in Biological Products for the Detoxification of Biocide-Contaminated Wastewater Prior to Conventional Biological Treatment. [PDF]
Biology (Basel), 2022 Loiko N +6 more
europepmc +1 more source