Results 71 to 80 of about 1,399,233 (310)

Experiences with the registration of biological plant protection products

, 2010
Die wichtigsten rechtlichen Rahmenbedingungen und Datenanforderungen für die Zulassung biologischer Pflanzenschutzmittel werden erläutert. Die Erfahrungen aus Zulassungsverfahren für unterschiedliche Mikro­organismen und Produkte werden zusammengefasst ...
Hauschild, Rüdiger
core   +1 more source

Research progress on the influence of ligands on the stability of albumin

Zhongguo shuxue zazhi
It is necessary to improve the stability of human serum albumin in response to the complex temperature, light and other conditions during the manufacture and storage.
Lieqing YANG, Rongchao YIN, Lei YANG, Jinrong JING, Haitao FANG, Jiaquan CHEN, Weixin LIU   +6 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The Protective Efficacy of a SARS-CoV-2 Vaccine Candidate B.1.351V against Several Variant Challenges in K18-hACE2 Mice

Vaccines
The emergence of SARS-CoV-2 variants of concern (VOCs) with increased transmissibility and partial resistance to neutralization by antibodies has been observed globally. There is an urgent need for an effective vaccine to combat these variants. Our study
Jie Yang, Huifen Fan, Anna Yang, Wenhui Wang, Xin Wan, Fengjie Lin, Dongsheng Yang, Jie Wu, Kaiwen Wang, Wei Li, Qian Cai, Lei You, Deqin Pang, Jia Lu, Changfu Guo, Jinrong Shi, Yan Sun, Xinguo Li, Kai Duan, Shuo Shen, Shengli Meng, Jing Guo, Zejun Wang   +22 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

A pharmaceutical model for the molecular evolution of microbial natural products [PDF]

, 2020
Microbes are talented chemists with the ability to generate tremendously complex and diverse natural products which harbor potent biological activities.
David P. Fewer, Metsä-Ketelä, Mikko, Fewer, David P., Mikko Metsä‐Ketelä   +3 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Biological Durability of Sapling-Wood Products Used for Gardening and Outdoor Decoration

, 2019
Sapling-wood products from different wood species such as willow (Salix spp. L.) and Common hazel (Corylus avellana L.) are frequently used for gardening and outdoor decoration purposes.
Nienaber, Dirk G.B., Lukas Emmerich, Bollmus, Susanne, Christian Brischke, Emmerich, Lukas, Dirk G.B. Nienaber, Susanne Bollmus, Brischke, Christian   +7 more
core   +1 more source

Advancements in extracellular vesicles biomanufacturing: a comprehensive overview of large-scale production and clinical research

Frontiers in Bioengineering and Biotechnology
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted by cells into the extracellular space, have attracted considerable attention in the field of biosciences for their role in intercellular communication in various physiological ...
Ziqian Li, Junyu Yan, Xiang Li, Hui Chen, Chen Lin, Yuhang Zhang, Tian Gao, Yabo Zhang, Yue Shu, Shuyuan Pan, Yuntao Zhang, Yuntao Zhang   +11 more
doaj   +1 more source