Results 51 to 60 of about 1,399,233 (310)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Enhancement of exogenous protein stability in AcMNPV by overexpressing lef5 gene during passaging

Applied Microbiology and Biotechnology
The baculovirus insect cell expression system is pivotal for exogenous protein expression. However, serial passages of baculovirus in insect cells often result in defective virus generation and a rapid decline in exogenous protein expression, limiting ...
Jie Pei, Ruilun Liu, Wei Li, Shasha Qian, Jie Yang, Shengli Meng, Shuo Shen, Jing Guo   +7 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Antiviral effect of chelerythrine chloride against tick-borne encephalitis virus

Virology Journal
Tick-borne encephalitis virus (TBEV) is a neurotropic Orthoflavivirus that causes severe encephalitis and long-term neurological sequelae. Due to the limited protection from existing vaccines and the absence of effective antiviral drugs, the prevention ...
Jiangdan Li, Dongmei Zhao, Shiqing Yan, Lu Qiu, Hanxiong Qin, Xianxian Gao, Bo Jiang, Wenjia Yu, Yue Zhu, Yue Tao, Kaiyu Zhang, Shuai Li   +11 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Bromotyrosine-derived natural products: synthetic and biological studies

, 2011
Bromotyrosine-derived natural products are a fascinating class of compounds that are produced by marine sponges of the order Verongida. Furthermore, they exhibit a rich variety of chemical structures and display a diverse range of bioactivities which ...

core   +1 more source

Mentha piperita: Essential Oil and Extracts, Their Biological Activities, and Perspectives on the Development of New Medicinal and Cosmetic Products

, 2023
This review aims to analyze Mentha piperita L. as a potential raw material for the development of new health-promoting products (nutraceuticals, cosmetics, and pharmaceutical products).
Mariia Voloshyn, Lesya Kobylinska, Jacek Lipok, Vladimira Horčinová Sedláčková, Iryna Myskiv, Katarzyna Pokajewicz, Roman Fedin, Ján Brindza, Nataliia Hudz, Piotr Paweł Wieczorek   +9 more
core   +1 more source

Genome sequence of Bovine Ephemeral fever virus vaccine strain of South African origin

Veterinary Medicine and Science, 2021
Bovine Ephemeral fever virus (BEFV) is endemic in South Africa and has a negative economic impact on the meat and dairy industries. Bovine ephemeral fever or three‐day stiff‐sickness is controlled through annual vaccination with a live attenuated virus ...
Tendai A. M. Mlingo, Bethuel M. Nthangeni, Nobalanda B. Mokoena   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Macromolecular excipients exert biological effects via their microbial fermentation absorbable products. [PDF]

, 2016
Fermentation of these macromolecular food or pharmaceutical excipient ingredients by the gut microbiota leads to the formation of short chain fatty acids (SCFA) which can be absorbed from the gut into the general circulation.
Shireesh Apte
core