Results 151 to 160 of about 1,871,491 (306)

Developing Skills in Second Year Biological Science Undergraduates [PDF]

, 2014
R. L. Robinson, James E. McDonald
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Biological Sciences [PDF]

Nature, 1980
openaire   +1 more source

Saporin as a Commercial Reagent: Its Uses and Unexpected Impacts in the Biological Sciences-Tools from the Plant Kingdom. [PDF]

Toxins (Basel), 2022
Ancheta LR, Shramm PA, Bouajram R, Higgins D, Lappi DA.   +4 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Research Journal of Agriculture and Biological Sciences

, 2020

openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Biological Sciences Table of Contents [PDF]

, 2014
R Adam, Miranda Konopka, Christopher Suer, Matthew Wolff, Harber, David Bunce, Allison Bielak, Kaarin Anstey, Nicolas Cherbuin, Philip Batterham, Simon Easteal, John Mach, Aniko Huizer-Pajkos, Victoria Cogger, Catriona Mckenzie, David Le Couteur, Brett Jones, Rafael De Cabo, Sarah Hilmer, Thanh Bui, Elisabet Tung, Manuel Rodrguez-Bies, Virginia Ballesteros-Simarro, Plcido Motilva, Guillermo Navas, Lpez-Lluch, Adam Lorenzini, Chad Salmon, Claudio Lerner, Yuji Torres, Susan Ikeno, Roger Motch, Christian Mccarter, Sell   +33 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Bridging artificial intelligence and biological sciences: a comprehensive review of large language models in bioinformatics. [PDF]

Brief Bioinform
Lin A, Ye J, Qi C, Zhu L, Mou W, Gan W, Zeng D, Tang B, Xiao M, Chu G, Peng S, Wong HZH, Zhang L, Zhang H, Deng X, Li K, Zhang J, Jiang A, Li Z, Luo P.   +19 more
europepmc   +1 more source