Results 41 to 50 of about 311,632 (269)

Mathematical model calibrated to in vitro data predicts mechanisms of antiviral action of the influenza defective interfering particle “OP7”

open access: yesiScience
Summary: Defective interfering particles (DIPs) are regarded as potent broad-spectrum antivirals. We developed a mathematical model that describes intracellular co-infection dynamics of influenza standard virus (STV) and “OP7”, a new type of influenza ...
Daniel Rüdiger   +6 more
doaj   +1 more source

New digital laboratories of experimental knowledge production: Artificial intelligence and education research

open access: yesLondon Review of Education, 2020
Education data scientists, learning engineers and precision education specialists are new experts in knowledge production in educational research. By bringing together data science methodologies and advanced artificial intelligence (AI) systems with ...
Ben Williamson
semanticscholar   +1 more source

An avian embryo patient-derived xenograft model for preclinical studies of human breast cancers

open access: yesiScience, 2021
Summary: Lack of preclinical patient-derived xenograft cancer models in which to conduct large-scale molecular studies seriously impairs the development of effective personalized therapies. We report here an in vivo concept consisting of implanting human
Loraine Jarrosson   +10 more
doaj   +1 more source

Immortalized human choroid plexus endothelial cells enable an advanced endothelial-epithelial two-cell type in vitro model of the choroid plexus

open access: yesiScience, 2022
Summary: The choroid plexus (CP) is a highly vascularized structure containing endothelial and epithelial cells located in the ventricular system of the central nervous system (CNS).
Walter Muranyi   +9 more
doaj   +1 more source

Long-working-distance high-collection-efficiency three-photon microscopy for in vivo long-term imaging of zebrafish and organoids

open access: yesiScience
Summary: Zebrafish and organoids, crucial for complex biological studies, necessitate an imaging system with deep tissue penetration, sample protection from environmental interference, and ample operational space.
Peng Deng   +19 more
doaj   +1 more source

GwAAP: A genome-wide amino acid coding-decoding quantitative proteomics system

open access: yesiScience, 2022
Summary: Mass spectrometry-based proteomic technology has greatly improved and has been widely applied in various biological science fields. However, proteome-wide accurate quantification of proteins in signaling pathways remains challenging.
Li Cheng   +6 more
doaj   +1 more source

The unpredictably eruptive dynamics of spruce budworm populations in eastern Canada

open access: yesPopulation Ecology, EarlyView.
We examine historical population data for spruce budworm from several locations through the period 1930–1997, and use density‐dependent recruitment curves to test whether the pattern of population growth over time is more consistent with Royama's (1984; Ecological Monographs 54:429–462) linear R(t) model of harmonic oscillation at Green River New ...
Barry J. Cooke, Jacques Régnière
wiley   +1 more source

Unraveling the aging-reversal potency of stem cell-derived extracellular vesicles in a rat model of premature cardiac senescence

open access: yesiScience
Summary: Cardiosphere-derived cells (CDCs) and their extracellular vesicles (CDC-EVs) can rejuvenate and improve cardiac function, but their efficacy varies among donors. This study aimed to identify predictors of CDC-EV potency.
Lidia Gómez-Cid   +8 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

A new murine esophageal organoid culture method and organoid-based model of esophageal squamous cell neoplasia

open access: yesiScience, 2021
Summary: Organoids mimic the physiologic and pathologic events of organs. However, no consensus on esophageal organoid (EO) culture methods has been reached.
Biyun Zheng   +11 more
doaj   +1 more source

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