Results 151 to 160 of about 1,815,049 (345)

A First Exposure to Statistical Mechanics for Life Scientists: Applications to Binding [PDF]

Statistical mechanics is one of the most powerful and elegant tools in the quantitative sciences. One key virtue of statistical mechanics is that it is designed to examine large systems with many interacting degrees of freedom, providing a clue that it ...
Hernan G. Garcia, Jané Kondev, Julie A. Theriot, Nigel Orme, Rob Phillips   +4 more
core  

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

DataONE: Data Observation Network for Earth - Preserving Data and Enabling Innovation in the Biological and Environmental Sciences

D-Lib Magazine, 2011
This paper describes DataONE, a federated data network that is being built to improve access to, and preserve data about, life on Earth and the environment that sustains it.
W. Michener, D. Vieglais, T. Vision, J. Kunze, P. Cruse, G. Janée   +5 more
semanticscholar   +1 more source

‘The uses of ethnography in the science of cultural evolution’. Commentary on Mesoudi, A., Whiten, A. and K. Laland ‘Toward a unified science of cultural evolution’ [PDF]

, 2006
There is considerable scope for developing a more explicit role for ethnography within the research program proposed in the article. Ethnographic studies of cultural micro-evolution would complement experimental approaches by providing insights into the “
Tehrani, J.
core  

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

The Nutrient Response Transcriptional Regulome of Arabidopsis

iScience, 2019
Summary: Plants respond actively to changes in their environment. Variations in nutrient availability elicit substantial transcriptional reprogramming, and we aimed to systematically describe these adjustments and identify the regulators responsible ...
Tzvetina Brumbarova, Rumen Ivanov
doaj   +1 more source

Using RDF to Model the Structure and Process of Systems

, 2007
Many systems can be described in terms of networks of discrete elements and their various relationships to one another. A semantic network, or multi-relational network, is a directed labeled graph consisting of a heterogeneous set of entities connected ...
Bollen, Johan, Gershenson, Carlos, Rodriguez, Marko A., Watkins, Jennifer H.   +3 more
core   +4 more sources

Lessons Learned from a Decade of Providing Interactive, On-Demand High Performance Computing to Scientists and Engineers

, 2019
For decades, the use of HPC systems was limited to those in the physical sciences who had mastered their domain in conjunction with a deep understanding of HPC architectures and algorithms.
Arcand, William, Bergeron, Bill, Bestor, David, Byun, Chansup, Gadepally, Vijay, Houle, Michael, Hubbell, Matthew, Jones, Michael, Kepner, Jeremy, Klein, Anna, Michaleas, Peter, Milechin, Lauren, Mullen, Julia, Prout, Andrew, Reuther, Albert, Rosa, Antonio, Samsi, Siddharth, Yee, Charles   +17 more
core   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source