Results 121 to 130 of about 4,020,279 (308)

Machine learning-led semi-automated medium optimization reveals salt as key for flaviolin production in Pseudomonas putida

Communications Biology
Although synthetic biology can produce valuable chemicals in a renewable manner, its progress is still hindered by a lack of predictive capabilities. Media optimization is a critical, and often overlooked, process which is essential to obtain the titers,
Apostolos Zournas, Matthew R. Incha, Tijana Radivojevic, Vincent Blay, Jose Manuel Martí, Zak Costello, Matthias Schmidt, Tan Chung, Mitchell G. Thompson, Allison Pearson, Patrick C. Kinnunen, Thomas Eng, Christopher E. Lawson, Stephen Tan, Tadeusz Ogorzalek, Nurgul Kaplan, Mark Forrer, Tyler Backman, Aindrila Mukhopadhyay, Nathan J. Hillson, Jay D. Keasling, Hector Garcia Martin   +21 more
doaj   +1 more source

Analysis of parametric biological models with non-linear dynamics

, 2012
In this paper we present recent results on parametric analysis of biological models. The underlying method is based on the algorithms for computing trajectory sets of hybrid systems with polynomial dynamics. The method is then applied to two case studies
Asarin, Batt, Batt, Belta, Berman, Britton, Chen, Clauss, Dang, Dang, Dang, Drulhe, Ezio Bartocci, Fotiou, Garloff, Grosu, H. Prautzsch and W. Boehm, Henzinger, I. Tchoupaeva, J. Garloff, J. Garloff and A.P. Smith, Luca Bortolussi, Prajna, Romain Testylier, S. Boyd and S. Vandenberghe, Sankaranarayanan, Thao Dang, Thao Dang   +27 more
core   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Process Algebraical Approach to Modelling Compartmentalized Biological Systems [PDF]

, 2007
This paper introduces Protein Calculus, a special modeling language designed for encoding and calculating the behaviors of compartmentilized biological systems.
Ihekwaba, Adaoha, Mardare, Radu
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Automation and machine learning drive rapid optimization of isoprenol production in Pseudomonas putida

Nature Communications
Advances in genome engineering have improved our ability to perturb microbial metabolic networks, yet bioproduction campaigns often struggle with parsing complex metabolic datasets to efficiently enhance product titers.
David N. Carruthers, Patrick C. Kinnunen, Yuerong Li, Yan Chen, Jennifer W. Gin, Ian S. Yunus, William R. Galliard, Stephen Tan, Tijana Radivojevic, Paul D. Adams, Anup K. Singh, Jess Sustarich, Christopher J. Petzold, Aindrila Mukhopadhyay, Hector Garcia Martin, Taek Soon Lee   +15 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Some aspects of modeling and analysis of complex biological systems using time Petri nets [PDF]

Bulletin of the Polish Academy of Sciences: Technical Sciences, 2018
J. Olszak, M. Radom, P. Formanowicz
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source