Results 121 to 130 of about 1,900,077 (315)

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Special Issue: Methods in Computational Biology [PDF]

, 2019
Biological systems are multiscale with respect to time and space, exist at the interface of biological and physical constraints, and their interactions with the environment are often nonlinear [...
Herbert M. Sauro, Ross P. Carlson
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Artificial Neural networks: powerful tools for modeling chaotic behavior in the nervous system

Frontiers in Computational Neuroscience, 2014
Malihe eMolaie, Razieh eFalahian, Shahriar eGharibzadeh, Sajad eJafari, Julien Clinton Sprott   +4 more
doaj   +1 more source

Sensory cues, behavior and fur-based drying in the rat wetness response

Scientific Reports
It never rains in standard lab-confinements; thus we have limited understanding of animal reactions to water and wetness. To address this issue, we sprayed water on different body parts of rats and measured drying and fur temperature by thermal imaging ...
Augustine Triumph Attah, Paola N. Negrón-Moreno, Macarena Amigo-Duran, Linghua Zhang, Max Kenngott, Michael Brecht, Ann M. Clemens   +6 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Machine learning-led semi-automated medium optimization reveals salt as key for flaviolin production in Pseudomonas putida

Communications Biology
Although synthetic biology can produce valuable chemicals in a renewable manner, its progress is still hindered by a lack of predictive capabilities. Media optimization is a critical, and often overlooked, process which is essential to obtain the titers,
Apostolos Zournas, Matthew R. Incha, Tijana Radivojevic, Vincent Blay, Jose Manuel Martí, Zak Costello, Matthias Schmidt, Tan Chung, Mitchell G. Thompson, Allison Pearson, Patrick C. Kinnunen, Thomas Eng, Christopher E. Lawson, Stephen Tan, Tadeusz Ogorzalek, Nurgul Kaplan, Mark Forrer, Tyler Backman, Aindrila Mukhopadhyay, Nathan J. Hillson, Jay D. Keasling, Hector Garcia Martin   +21 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

A systems biology approach to multi-scale modelling and analysis of planar cell polarity in drosophila melanogaster wing [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Systems biology aims to describe and understand biology at a global scale where biological systems function as a result of complex mechanisms that happen at
Gao, Qian
core