Results 111 to 120 of about 4,020,279 (308)

A geometric and structural approach to the analysis and design of biological circuit dynamics: a theory tailored for synthetic biology [PDF]

, 2020
Much of the progress in developing our ability to successfully design genetic circuits with predictable dynamics has followed the strategy of molding biological systems to fit into conceptual frameworks used in other disciplines, most notably the ...
Marken, John P., Murray, Richard M., Xiao, Fangzhou   +2 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Biological Systems [PDF]

Science, 1988
openaire   +3 more sources

Modelling Cell Cycle using Different Levels of Representation

, 2009
Understanding the behaviour of biological systems requires a complex setting of in vitro and in vivo experiments, which attracts high costs in terms of time and resources.
Antonio Cerone, Gabriel Ciobanu, Rafael V. Carvalho, Thomas Anung Basuki   +3 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Environmental Noise and Nonlinear Relaxation in Biological Systems [PDF]

, 2011
We analyse the effects of environmental noise in three different biological systems: (i) mating behaviour of individuals of \emph{Nezara viridula} (L.) (Heteroptera Pentatomidae); (ii) polymer translocation in crowded solution; (iii) an ecosystem ...
Adorno, D. Persano, Bue, P. Lo, Colazza, S., Curcio, L., Dubkov, A. A., Fiasconaro, A., Peri, E., Pizzolato, N., Spagnolo, B., Spezia, S., Valenti, D.   +10 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Sensory cues, behavior and fur-based drying in the rat wetness response

Scientific Reports
It never rains in standard lab-confinements; thus we have limited understanding of animal reactions to water and wetness. To address this issue, we sprayed water on different body parts of rats and measured drying and fur temperature by thermal imaging ...
Augustine Triumph Attah, Paola N. Negrón-Moreno, Macarena Amigo-Duran, Linghua Zhang, Max Kenngott, Michael Brecht, Ann M. Clemens   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Artificial Neural networks: powerful tools for modeling chaotic behavior in the nervous system

Frontiers in Computational Neuroscience, 2014
Malihe eMolaie, Razieh eFalahian, Shahriar eGharibzadeh, Sajad eJafari, Julien Clinton Sprott   +4 more
doaj   +1 more source