Results 101 to 110 of about 4,020,279 (308)

Fluorescent amplification for next generation sequencing (FA-NGS) library preparation

BMC Genomics, 2020
Background Next generation sequencing (NGS) has become a universal practice in modern molecular biology. As the throughput of sequencing experiments increases, the preparation of conventional multiplexed libraries becomes more labor intensive ...
Jennifer Chiniquy, Megan E. Garber, Aindrila Mukhopadhyay, Nathan J. Hillson   +3 more
doaj   +1 more source

Measurement in biological systems from the self-organisation point of view

, 2015
Measurement in biological systems became a subject of concern as a consequence of numerous reports on limited reproducibility of experimental results.
A.K. Dewdney, A.M. Turing, C.G. Begley, D. Štys, D.H.E. Gross, E. Klipp, F. Prinz, G.D. Birkhoff, H. Poincare, J.M. Greenberg, J.P. Crutchfield, L.S. Tsimring, M. Loose, M.C. Cross   +13 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Microgravity-Induced Alterations in Human Physiology and Cellular Homeostasis During Long-Duration Spaceflight

Exon
Astronaut’s health is at risk when they spend a long time in space because being in microgravity for a long time can throw off their physiological systems and cellular homeostasis. This manuscript synthesises current research on the systemic and cellular
Rashmi Trivedi, Chirag Prajapati
doaj   +1 more source

Correction to: Production efficiency of the bacterial non-ribosomal peptide indigoidine relies on the respiratory metabolic state in S. cerevisiae

Microbial Cell Factories, 2019
Following publication of the original article [1], the authors have noted that the standard curve in Additional file 1: Figure S7 is incorrect.
Maren Wehrs, Jan-Philip Prahl, Jadie Moon, Yuchen Li, Deepti Tanjore, Jay D. Keasling, Todd Pray, Aindrila Mukhopadhyay   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The context-dependence of mutations: a linkage of formalisms

, 2015
Defining the extent of epistasis - the non-independence of the effects of mutations - is essential for understanding the relationship of genotype, phenotype, and fitness in biological systems.
Krishna, Vinod, Poelwijk, Frank J., Ranganathan, Rama   +2 more
core   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Application of biological filters in water treatment systems [PDF]

, 1973
Silver chloride placed on or close to barrier kills bacteria as they arrive. Dead bacteria accumulate linearly, whereas previously, live bacteria accumulated exponentially.
Bambenek, R. A., Hurley, T. L.
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source