Results 81 to 90 of about 1,900,077 (315)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Role of Nitric Oxide in Biological Systems: A Systematic Review

Journal of Mazandaran University of Medical Sciences, 2017
Nitric oxide (NO) is known as an unstable signaling molecule that can be produced by three different NO synthase (NOS) isoforms. It plays a vital role in a wide range of physiological processes in the body.
Fatemeh Mirzaei, Mozafar Khazaei
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Statistical scaling laws for competing biological species [PDF]

, 2018
Universality classes are defined for an idealized nonlinear system that governs the competition between biological species. The decay to asymptotic steady state is examined for supercritical Hopf bifurcation by considering a phenomenological approach ...
Silva, Vinicius Barros da [UNESP], da Silva, Vinícius Barros [UNESP]   +1 more
core   +1 more source

Xylose induces cellulase production in Thermoascus aurantiacus

Biotechnology for Biofuels, 2017
Background Lignocellulosic biomass is an important resource for renewable production of biofuels and bioproducts. Enzymes that deconstruct this biomass are critical for the viability of biomass-based biofuel production processes.
Timo Schuerg, Jan-Philip Prahl, Raphael Gabriel, Simon Harth, Firehiwot Tachea, Chyi-Shin Chen, Matthew Miller, Fabrice Masson, Qian He, Sarah Brown, Mona Mirshiaghi, Ling Liang, Lauren M. Tom, Deepti Tanjore, Ning Sun, Todd R. Pray, Steven W. Singer   +16 more
doaj   +1 more source

Thermodynamic calculations in biological systems

Biophysical Chemistry, 2005
The ability to compute intra- and inter-molecular interactions provides the opportunity to gain a deeper understanding of previously intractable problems in biochemistry and biophysics. This review presents three examples in which molecular dynamics calculations were used to gain insight into the atomic detail underlying important experimental ...
Amzel, L. Mario, Siebert, Xavier, Armstrong, Anthony, Pabon, German   +3 more
openaire   +3 more sources

Modelling Coordination in Biological Systems [PDF]

, 2006
We present an application of the Reo coordination paradigm to provide a compositional formal model for describing and reasoning about the behaviour of biological systems, such as regulatory gene networks. Reo governs the interaction and flow of data between components by allowing the construction of connector circuits which have a precise formal ...
D.G. Clarke (David), D. Costa (David), F. Arbab (Farhad)   +2 more
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Determine measurement set for parameter estimation in biological systems modeling [PDF]

, 2012
Parameter estimation is challenging for biological systems modelling since the model is normally of high dimension, the measurement data are sparse and noisy, and the cost of experiments is high. Accurate recovery of parameters depend on the quantity and
Jia, J.F., Yue, Hong
core  

Mathematical and computational modeling of biosystems at different levels of organization

Вавиловский журнал генетики и селекции
Modern biology increasingly relies on mathematical and computational modeling to describe complex hierarchically organized biological systems. This review considers models that cover the main levels of biological organization, from the molecular-genetic ...
S. A. Lashin, R. A. Ivanov, Y. G. Matushkin   +2 more
doaj   +1 more source