Results 1 to 10 of about 343,671 (199)
Transport, stability, and biological activity of resveratrol [PDF]
Annals of the New York Academy of Sciences, 2011 Numerous studies have reported interesting properties oftrans‐resveratrol, a phytoalexin, as a preventive agent of several important pathologies: vascular diseases, cancers, viral infections, and neurodegenerative processes. These beneficial effects of resveratrol have been supported by observations at the cellular and molecular levels in both cellular
Frédéric Mazué +13 more
openaire +3 more sources
Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers
International Journal of Molecular Sciences, 2022 Ultrashort peptides (USPs), consisting of 2–7 amino-acid residues, are a group of signaling molecules that regulate gene expression and protein synthesis under normal conditions in various diseases and ageing. USPs serve as a basis for the development of drugs with a targeted mechanism of action.
Vladimir Khavinson +4 more
openaire +2 more sources
RSC Advances, 2021 A series of squaramido-tethered bisbenzimidazoles were synthesized and found to exhibit moderate anion transport and cytotoxicity.
Yuan-Yuan Xing +5 more
openaire +3 more sources
Cl−-ATPases: biological active transporters
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2001 Five widely documented mechanisms of chloride transport across plasma membranes are: anion-coupled antiport; sodium and hydrogen-coupled symport; Cl- channels; and an electrochemical coupling process. No genetic evidence has yet been provided for primary active chloride transport despite numerous reports of cellular Cl(-)-stimulated ATPases co-existing,
Department of Physiology and Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610-0274, USA ( host institution ) +2 more
openaire +4 more sources
Biological activity of synthetic ionophores: ion transporters as prospective drugs? [PDF]
Chemical Science, 2013 AbstractReview: 111 refs.
Roberto Quesada, Ignacio Alfonso
openaire +2 more sources
Biomolecules, 2023 The aim of this work is to verify the possibility of transport of 26 biologically active ultrashort peptides (USPs) into cells via LAT and PEPT family transporters. Molecular modeling and computer-assisted docking of peptide ligands revealed that the size and structure of ligand-binding sites of the amino acid transporters LAT1, LAT2, and of the ...
Vladimir Khatskelevich Khavinson +3 more
openaire +3 more sources
Active Materials: Biological Benchmarks and Transport Limitations
, 2022 Abstract Recent works in cellular and molecular biophysics suggest that activity can drive dramatic changes to the properties of living materials and their fluctuations. Experimental investigations of active materials pose some challenges.
openaire +2 more sources
Collective protection and transport in entangled biological and robotic active matter [PDF]
, 2020 Living systems at all scales aggregate in large numbers for a variety of functions including mating, predation, and survival. The majority of such systems consist of unconnected individuals that collectively flock, school or swarm. However some aggregations involve physically entangled individuals, which can confer emergent mechanofunctional material ...
Yasemin Ozkan-Aydin +2 more
openaire +2 more sources
Discovery of a Biological Mechanism of Active Transport through the Tympanic Membrane to the Middle Ear [PDF]
Scientific Reports, 2016 AbstractOtitis media (OM) is a common pediatric disease for which systemic antibiotics are often prescribed. While local treatment would avoid the systemic treatment side-effects, the tympanic membrane (TM) represents an impenetrable barrier unless surgically breached.
Allen F. Ryan +5 more
openaire +6 more sources
Synthesis and Biological Evaluation of Dihydromotuporamine Derivatives in Cells Containing Active Polyamine Transporters [PDF]
Journal of Medicinal Chemistry, 2005 Dihydromotuporamine C (4) and its 4,4-triamine analogue (5) were synthesized in good yield using ring-closing metathesis (RCM) methods. Comparison of their biological activities (Ki determinations in L1210 cells and IC50 determinations in L1210, CHO, and CHO-MG cells) revealed that the motuporamine derivatives do not use the polyamine transporter (PAT)
Navneet Kaur +3 more
openaire +4 more sources