Results 41 to 50 of about 7,740,932 (262)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Walking, riding and access to public transport: Draft report for discussion [PDF]
, 2012 Walking and riding are fundamental everyday modes of transport and are a vital component of Australia\u27s transport system. Many people walk to local destinations such as their local shops, cafes or services such as the post office or library.
core
Evolutionary ancestry and novel functions of the mammalian glucose transporter (GLUT) family
BMC Evolutionary Biology, 2010 Background In general, sugar porters function by proton-coupled symport or facilitative transport modes. Symporters, coupled to electrochemical energy, transport nutrients against a substrate gradient.
Patron Nicola +2 more
doaj +1 more source
In vitro transport of methotrexate by Drosophila Multidrug Resistance-associated Protein. [PDF]
PLoS ONE, 2018 Methotrexate (MTX) is a widely used chemotherapeutic agent, immune suppressant and antimalarial drug. It is a substrate of several human ABC proteins that confer multidrug resistance to cancer cells and determine compartmentalization of a wide range of ...
Agnes Karasik +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Overcrowding induces fast colloidal solitons in a slowly rotating potential landscape
Nature Communications, 2023 Collective particle transport across periodic energy landscapes is ubiquitously present in many condensed matter systems spanning from vortices in high-temperature superconductors, frictional atomic sliding, driven skyrmions to biological and active ...
Eric Cereceda-López +4 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Biodiversity in Motion: How Marine Diversity Shapes the Ocean’s Active Carbon Pump
DiversityThe biological carbon pump plays a central role in regulating atmospheric CO2 by transporting carbon from the surface ocean to depth. Although diel vertical migration and the Active Migrant Pump (AMP) are increasingly recognized as important components ...
Alexander Vereshchaka
doaj +1 more source
Methodological advances in imaging intravital axonal transport [version 1; referees: 3 approved]
F1000Research, 2017 Axonal transport is the active process whereby neurons transport cargoes such as organelles and proteins anterogradely from the cell body to the axon terminal and retrogradely in the opposite direction.
James N. Sleigh +3 more
doaj +1 more source