Results 61 to 70 of about 7,740,932 (262)

Hydrodynamics of a Granular Gas in a Heterogeneous Environment

Entropy, 2017
We analyze the transport properties of a low density ensemble of identical macroscopic particles immersed in an active fluid. The particles are modeled as inelastic hard spheres (granular gas).
Francisco Vega Reyes, Antonio Lasanta
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Health impacts of active transportation in Europe [PDF]

, 2016
Policies that stimulate active transportation (walking and bicycling) have been related to heath benefits. This study aims to assess the potential health risks and benefits of promoting active transportation for commuting populations (age groups 16-64 ...
Mark J. Nieuwenhuijsen (71949), Nieuwenhuijsen, Mark J., Rojas-Rueda, D, Martina S. Ragettli (1445584), Ragettli, MS, Marko Tainio (2476390), Hélène Desqueyroux, David Rojas-Rueda (2547895), Ragettli, Martina S, Zorana J Andersen, Tainio, M, Nieuwenhuijsen, MJ, Nieuwenhuijsen, Mark J, Corinne Praznoczy, Rojas-Rueda, David, Jan Bruha, Bruhova-Foltynova, H, Desqueyroux, Hélène, Praznoczy, C, Mark J Nieuwenhuijsen, Hélène Desqueyroux (2547901), Braun-Fahrländer, Charlotte, Hana Bruhova-Foltynova, de Nazelle, A, Audrey de Nazelle (1821121), Ragettli, Martina S., Jan Bruha (2547904), Hana Bruhova-Foltynova (2547907), Andersen, Zorana J, Nazelle, Audrey de, Rojas Rueda, David, 1979-, Desqueyroux, H, Ragettli, Martine S., Martina S Ragettli, Bruha, Jan, Bruhova-Foltynova, Hana, Braun-Fahrlaender, C, Corinne Praznoczy (2547898), Andersen, ZJ, Tainio, Marko, Charlotte Braun-Fahrländer, Praznoczy, Corinne, Andersen, Zorana J., David Rojas-Rueda, Zorana J. Andersen (318777), Charlotte Braun-Fahrländer (18248), de Nazelle, Audrey, Marko Tainio, Rojas Rueda, David, Bruha, J, Audrey de Nazelle   +50 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An active RNA transport mechanism into plant vacuoles [PDF]

RNA degradation inside the plant vacuole by the ribonuclease RNS2 is essential for maintaining nucleotide concentrations and cellular homeostasis via the nucleotide salvage pathway. However, the mechanisms by which RNA is transported into the vacuole are
Wong, Min May, Liu, Ang-Yu, Kazibwe, Zakayo, Venkatesan, Elakkiya, Ridout, Victoria, Bassham, Diane, Morriss, Stephanie, Floyd, Brice, Mugume, Yosia, Macintosh, Gustavo, Luo, Xinjuan   +10 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Dynamic coordination engineering of gallium biomaterials: A biological accessibility framework for therapeutic biofunction

Bioactive Materials
Gallium (Ga)-based biomaterials have emerged as versatile therapeutic platforms owing to the iron-mimicking properties and broad biological activities of gallium.
Yin Zhou, Wanjia Peng, Jingwei Shi, José Luis Pedraz, Zhongwei Gu, Yiyan He   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source