Results 51 to 60 of about 1,074,318 (296)

In vitro transport of methotrexate by Drosophila Multidrug Resistance-associated Protein. [PDF]

PLoS ONE, 2018
Methotrexate (MTX) is a widely used chemotherapeutic agent, immune suppressant and antimalarial drug. It is a substrate of several human ABC proteins that confer multidrug resistance to cancer cells and determine compartmentalization of a wide range of ...
Agnes Karasik, András Váradi, Flóra Szeri   +2 more
doaj   +1 more source

Hydrodynamic Collective Effects of Active Protein Machines in Solution and Lipid Bilayers

, 2015
The cytoplasm and biomembranes in biological cells contain large numbers of proteins that cyclically change their shapes. They are molecular machines that can function as molecular motors or carry out many other tasks in the cell.
Kapral, Raymond, Mikhailov, Alexander
core   +1 more source

Using small molecules to facilitate exchange of bicarbonate and chloride anions across liposomal membranes [PDF]

, 2009
Bicarbonate is involved in a wide range of biological processes, which include respiration, regulation of intracellular pH and fertilization. In this study we use a combination of NMR spectroscopy and ion-selective electrode techniques to show that the ...
A Fürstner, AP Davis, AV Koulov, C Yamamoto, D Stefayne, E Gout, ED Steinle, F Hofmeister, FA Norris, FG Riddell, HG Hempling, HM Florman, J Fujinaga, Jeffery T. Davis, JL Sessler, Jose Carlos Iglesias-Sánchez, JR Casey, JW Bennett, JY Choi, K Chang, K Kavallieratos, K Tanigaki, L You, M Nguyen, MS Melvin, NM Koropatkin, NN Gerber, NR Williamson, OA Okunola, Oluyomi A. Okunola, Philip A. Gale, Pilar Prados, PV Santacroce, RA Gottlieb, Roberto Quesada, S Ohkuma, T Sato, Tomás Torroba, V Rizzo, WN Lipscomb, WW Cleland, X Li   +41 more
core   +1 more source

Guanine-based amphiphiles: synthesis, ion transport properties and biological activity

Bioorganic & Medicinal Chemistry, 2015
Novel amphiphilic guanine derivatives, here named Gua1 and Gua2, have been prepared through few, simple and efficient synthetic steps. In ion transport experiments through phospholipid bilayers, carried out to evaluate their ability to mediate H(+) transport, Gua2 showed high activity.
MUSUMECI, DOMENICA, IRACE, CARLO, SANTAMARIA, RITA, Milano, Domenico, Tecilla, Paolo, MONTESARCHIO, DANIELA   +5 more
openaire   +4 more sources

Cell biological mechanisms of activity-dependent synapse to nucleus translocation of CRTC1 in neurons. [PDF]

, 2015
Previous studies have revealed a critical role for CREB-regulated transcriptional coactivator (CRTC1) in regulating neuronal gene expression during learning and memory. CRTC1 localizes to synapses but undergoes activity-dependent nuclear translocation to
Ch'ng, Toh Hean, DeSalvo, Martina, Lin, Peter, Martin, Kelsey C, Vashisht, Ajay, Wohlschlegel, James A   +5 more
core   +1 more source

Synthesis and biological activity of squaramido-tethered bisbenzimidazoles as synthetic anion transporters

RSC Advances, 2021
A series of squaramido-tethered bisbenzimidazoles were synthesized and found to exhibit moderate anion transport and cytotoxicity.
Zhong-Kun Wang, Xiao-Qiao Hong, Jinhui Hu, Yuan-Yuan Xing, Wen-Hua Chen   +4 more
openaire   +3 more sources

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

206 An artificial active DNA transporter from biological building blocks [PDF]

Journal of Biomolecular Structure and Dynamics, 2013
The selective transport of molecules across membrane pores is an essential biological process that occurs in all living organisms. Examples include the chaperone of proteins and mRNA in and out the cell nucleus mediated by the nuclear pore complex and the transport of specific molecules across a biological membrane mediated by active and passive ...
Lorenzo Franceschini, Misha Soskine, Giovanni Maglia   +2 more
openaire   +1 more source

Infection Control Practices for Vascular Access Management in Hemodialysis: Results From a Nationwide Survey of Japanese National University Hospitals

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Bloodstream infections due to repeated vascular access (VA) puncture and circuit connections remain major concerns in hemodialysis. Therefore, we examined current practices for glove, disinfectant, and personal protective equipment (PPE) use according to VA type in national university hospitals in Japan.
Aiko Yamada, Makoto Harada, Tadahiko Kikugawa, Takeshi Nakata, Koji Hashimoto, Tsuneo Konta, Yuji Kamijo   +6 more
wiley   +1 more source

Overcrowding induces fast colloidal solitons in a slowly rotating potential landscape

Nature Communications, 2023
Collective particle transport across periodic energy landscapes is ubiquitously present in many condensed matter systems spanning from vortices in high-temperature superconductors, frictional atomic sliding, driven skyrmions to biological and active ...
Eric Cereceda-López, Alexander P. Antonov, Artem Ryabov, Philipp Maass, Pietro Tierno   +4 more
doaj   +1 more source