Results 81 to 90 of about 7,740,932 (262)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1909

, 1910
Annual report of the Marine Biological Laboratory in Woods Hole. 1909.
Marine Biological Laboratory (Woods Hole MA)
core  

Bioinks in systems biology: integrating biomaterial design with cellular network modelling for predictive biofabrication

Frontiers in Bioengineering and Biotechnology
Bioinks facilitate patient-relevant tissue models by merging living cells with a programmable matrix whose composition, mechanics, and transport properties can be altered in three dimensions and tracked over time.
Inamul Hasan Madar, Jayant Pawar, Punitha Muruganantham, Syed Suhaib Ahmed, Vansh Vohra, Janakiraman Velayudam   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1925

, 1926
Annual report of the Marine Biological Laboratory in Woods Hole. 1925.
Marine Biological Laboratory (Woods Hole MA)
core  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1940

, 1941
Annual report of the Marine Biological Laboratory in Woods Hole. 1940.
Marine Biological Laboratory (Woods Hole MA)
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1917

, 1918
Annual report of the Marine Biological Laboratory in Woods Hole. 1917.
Marine Biological Laboratory (Woods Hole MA)
core  

Nano-Organic Compounds in Targeted Drug Delivery: A Review

Al-SalamJournal for Medical Science
The conventional pharmaceutical delivery methods have dose-related toxicity, poor solubility, quick systemic clearance, nonspecific biodistribution, and restricted tissue penetration.
Shahad M. Hussain, Rania Kareem, Muna Emad Abd Al-Fattah, Basma H. Bedair, Baneen S. Rasool   +4 more
doaj   +1 more source