Results 101 to 110 of about 426,699 (266)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Novel Biological Nanopore for Active DNA Transport and Detection [PDF]

Biophysical Journal, 2018
Ke Sun, Yuejia Chen, Xialin Zhang, Changjian Zhao, Jia Geng   +4 more
openaire   +1 more source

Robust Edge Flows in Swarming Bacterial Colonies

Physical Review X
Understanding if and how the chirality of biomolecules is transferred across scales into larger components and active processes remains elusive. For instance, flagellated bacteria swim in helical trajectories but chirality seems absent from the active ...
He Li, Hugues Chaté, Masaki Sano, Xia-qing Shi, H. P. Zhang   +4 more
doaj   +1 more source

Investigation of transport properties of hydroxyapatite and its silicon-substituted derivatives

Физико-химические аспекты изучения кластеров, наноструктур и наноматериалов
The article discusses the possibility of practical application of hydroxyapatite and silicon-substituted hydroxyapatite as components of medicines, pharmaceutical compositions, and biomaterials, the use of which is based on the transdermal delivery route
E.A. Bogdanova, T.G. Khonina, N.A. Sabirzyanov   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Genetically encoded biosensor enabled mining, characterisation and engineering of aromatic acid MFS transporters

Journal of Biological Engineering
Active transport of chemical species across the cell membrane represents a critical biological and biotechnological function, allowing the cell to selectively import compounds of nutritional value whilst exporting potentially toxic compounds.
Philip Le Roy, Micaela Chacόn, Neil Dixon   +2 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy

Advanced Science
Designing drugs to intelligently respond to different ratio of biological electron donors/receptors in cancer cells and normal cells is a promising strategy to achieve highly effective and less toxic chemotherapy.
Xiaoyu Qin, Junxian Guo, Hui Li, Hanlong He, Fei Cai, Xinyan Chen, Mingkai Chen, Tianfeng Chen, Li Ma   +8 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Cilia induced transport of microorganisms in Bingham plastic fluid with wall slip in asymmetric microchannel

Scientific Reports
Bingham plastic fluids are frequently found in both biological and industrial contexts, especially in situations requiring the movement of mucus, chyme, or blood that has unusual viscosity through microchannels.
N. Ibrahim, Maryiam Javed, N. Imran, Lemessa Asefa Eressa   +3 more
doaj   +1 more source