Results 111 to 120 of about 8,094,321 (309)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Chemically Fueled Active Transport

Biology uses chemical potential differences from molecules like ATP to drive membrane pumps, transporting molecules across membranes even against concentration gradients.
Kriebisch, Brigitte A. K., Kriebisch, Christine M. E., Fei, Yanyan, Boekhoven, Job, Soria-Carrera, Hector, Häfner, Gregor, Müller, Marcus, Kriebisch, Christine M. E. ; Kriebisch, Brigitte A. K. ; Häfner, Gregor ; Soria-Carrera, Héctor ; Fei, Yanyan ; Müller, Marcus ; Boekhoven, Job   +7 more
core   +1 more source

Nano-Organic Compounds in Targeted Drug Delivery: A Review

Al-SalamJournal for Medical Science
The conventional pharmaceutical delivery methods have dose-related toxicity, poor solubility, quick systemic clearance, nonspecific biodistribution, and restricted tissue penetration.
Shahad M. Hussain, Rania Kareem, Muna Emad Abd Al-Fattah, Basma H. Bedair, Baneen S. Rasool   +4 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Nature-inspired solid-state proton diode membrane for high-performance force-electric conversion

Nature Communications
Bioinspired ion channel membranes with ultrafast and directional transport capabilities, akin to biological protein-based channel, are crucial for various energy and sensing applications. However, controlling highly active protons and advancing practical
Dandan Lei, Qixiang Zhang, Yixiang Wang, Shuqi Wang, Naijia Zhao, Lei Jiang, Zhen Zhang   +6 more
doaj   +1 more source

Construction and Functional Engineering of Bio-Integrated Micro/Nanorobots for Theranostic Applications

Micromachines
Bio-integrated micro/nanorobots combine intrinsic biological properties with engineered capabilities, offering promising platforms for biomedical intervention.
Junfeng Wu, Zhaoyu Zhang, Niandong Jiao, Enkuo Li, Yuting Cui, Mengyao Tong, Yan Zhou, Wenfeng Liang   +7 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source