Results 91 to 100 of about 7,740,932 (262)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1934
Annual report of the Marine Biological Laboratory in Woods Hole. 1934.
Marine Biological Laboratory (Woods Hole MA)
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1929
Annual report of the Marine Biological Laboratory in Woods Hole. 1929.
Marine Biological Laboratory (Woods Hole MA)
core
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1989
Annual report of the Marine Biological Laboratory in Woods Hole. 1989.
Marine Biological Laboratory (Woods Hole MA)
core
Nature-inspired solid-state proton diode membrane for high-performance force-electric conversion
Bioinspired ion channel membranes with ultrafast and directional transport capabilities, akin to biological protein-based channel, are crucial for various energy and sensing applications. However, controlling highly active protons and advancing practical
Dandan Lei +6 more
doaj +1 more source
The East Pacific Rise Between 9°N and 10°N: Twenty-Five Years of Integrated, Multidisciplinary Oceanic Spreading Center Studies [PDF]
The East Pacific Rise from ~ 9–10°N is an archetype for a fast-spreading mid-ocean ridge. In particular, the segment near 9°50'N has been the focus of multidisciplinary research for over two decades, making it one of the best-studied areas of the global ...
Daniel J. Fornari +16 more
doaj
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Annual Report - Marine Biological Laboratory, 1893
Annual report of the Marine Biological Laboratory in Woods Hole. 1893.
Marine Biological Laboratory (Woods Hole MA)
core

