Aging and Cancer, EarlyView.Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley +1 more source
Cryo-EM of human P-glycoprotein reveals an intermediate occluded conformation during active drug transport. [PDF]
Nat CommunCulbertson AT, Liao M.
europepmc +1 more source
A Python package for fast GPU‐based proton pencil beam dose calculation
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose Open‐source GPU‐based Monte Carlo (MC) proton dose calculation algorithms provide high speed and unparalleled accuracy but can be complex to integrate with new applications and remain slower than GPU‐based pencil beam (PB) methods, which sacrifice some physical accuracy for sub‐second plan calculation.
Mahasweta Bhattacharya +4 more
wiley +1 more source
<i>Pseudogymnoascus destructans</i> Transcriptional Response to Chronic Copper Stress. [PDF]
J Fungi (Basel)Anne S, McDonald MR, Lu Y, Peterson RL.
europepmc +1 more source
Machine stability and dosimetry for ultra‐high dose rate FLASH radiotherapy human clinical protocol
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Background The FLASH effect, induced by ultra‐high dose rate (UHDR) irradiations, offers the potential to spare normal tissue while effectively treating tumors. It is important to achieve precise and accurate dose delivery and to establish reliable detector systems, particularly for clinical trials needed to help the clinical transfer of FLASH‐
Patrik Gonçalves Jorge +9 more
wiley +1 more source
Targeting mitochondria with natural polyphenols for treating Neurodegenerative Diseases: a comprehensive scoping review from oxidative stress perspective. [PDF]
J Transl MedGuan Y, Li L, Yang R, Lu Y, Tang J.
europepmc +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract Purpose An evaluation of the accuracy, safety, and efficiency of the Halcyon ring delivery system (RDS) for stereotactic radiosurgery (SRS) treatment to relatively small (1–3 cm) brain lesions. Methods After completing the extensive in‐house quality assurance checks including Winston–Lutz test and independent dose verification via MD Anderson ...
Kate Hazelwood +5 more
wiley +1 more source
Drought-Driven Divergence in Photosynthetic Performance Between Two <i>Cunninghamia lanceolata</i> Provenances: Insights from Gas Exchange and Chlorophyll Fluorescence Dynamics. [PDF]
Plants (Basel)Gong X, Wan Z, Jin P, Jin S, Li X.
europepmc +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract The establishment of guidelines and curriculum standards for medical physics residency training is a critical component of setting expectations and competencies for the profession. Since the last publication of these standards, residency training has become integrated into the eligibility criteria for most medical physics certification bodies.
Jonathon A. Nye +16 more
wiley +1 more source
Chitosan and Its Derivatives as Nanocarriers for Drug Delivery. [PDF]
MoleculesBiswas R +6 more
europepmc +1 more source