Results 121 to 130 of about 5,577,040 (294)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Direct evidence of the molecular basis for biological silicon transport

Nature Communications, 2016
Diatoms sheath themselves in a self-made casing of silica, which requires the function of silicic acid transporters. Here, the authors identify versions of these transporters that are experimentally tractable, and develop a fluorescence method to study ...
Michael J. Knight, Laura Senior, Bethany Nancolas, Sarah Ratcliffe, Paul Curnow   +4 more
doaj   +1 more source

Cl−-ATPases: biological active transporters

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2001
Five widely documented mechanisms of chloride transport across plasma membranes are: anion-coupled antiport; sodium and hydrogen-coupled symport; Cl- channels; and an electrochemical coupling process. No genetic evidence has yet been provided for primary active chloride transport despite numerous reports of cellular Cl(-)-stimulated ATPases co-existing,
Department of Physiology and Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610-0274, USA ( host institution ), Gerencser, George A ( author ), Zhang, Jianliang ( author )   +2 more
openaire   +3 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Spatial moment analysis of transport of nonlinearly absorbing pesticides using analytical approximations

, 2008
Analytical approximations were derived for solute transport of pesticides subject to Freundlich sorption, and first-order degradation restricted to the liquid phase.
Wim H. J. Beltman, Boesten, J.J.T.I., Sjoerd E. A. T. M. van der Zee, Beltman, W.H.J., Jos J. T. I. Boesten, Zee, S.E.A.T.M., van der, van der Zee, S.E.A.T.M.   +6 more
core   +1 more source

Macroscopic transport by synthetic molecular machines [PDF]

, 2005
Nature uses molecular motors and machines in virtually every significant biological process, but demonstrating that simpler artificial structures operating through the same gross mechanisms can be interfaced with—and perform physical tasks in—the ...
Emilio M. Pérez, Berná, José,, Zerbetto, Francesco,, Lubomska, Monika,, David A. Leigh, Francesco Zerbetto, Berna, J, Sandra M. Mendoza, Leigh, David A.,, Teobaldi, G, Teobaldi, Gilberto,, Rudolf, Petra,, Leigh, DA, Gilberto Teobaldi, Mendoza, Sandra M.,, Zerbetto, F, Perez, EM, Monika Lubomska, Lubomska, M, Mendoza, SM, Rudolf, P, José Berná, Rudolf, P; id_orcid, Pérez, Emilio M.,, Petra Rudolf   +24 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source

Mathematical modelling of transporter kinetics [PDF]

Membrane transport proteins have recently been discovered to be ubiquitously expressed in the human body and of paramount importance in cellular uptake.
Grandjean, Thomas R. B.
core