Results 131 to 140 of about 5,577,040 (294)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Molecular investigation if the rat jejunal active nucleoside transport protein rCNT1 [PDF]
, 1998 Active, sodium-dependent nucleoside transport systems have been kinetically described in a number of different mammalian tissues. The recent cloning of several active, mammalian nucleoside transporters belonging to a novel gene family has provided an ...
Hamilton, Stephen Robin
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Ions in motion: From biological channels to engineered transport systems
GiantNatural membrane proteins are molecular machines evolved over billions of years, playing crucial roles in various physiological functions by precisely mediating transmembrane transport processes.
Bei Wu +5 more
doaj +1 more source
Study on Photon Transport Problem Based on the Platform of Molecular Optical Simulation Environment
International Journal of Biomedical Imaging, 2010 As an important molecular imaging modality, optical imaging has attracted increasing attention in the recent years. Since the physical experiment is usually complicated and expensive, research methods based on simulation platforms have obtained extensive
Kuan Peng +7 more
doaj +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Qualitative behavioral assessment of sheep during transport
, 2011 Animal welfare is a growing concern for society and research into the welfare of animals has increased. Assessment of animal welfare usually includes physiological as well as behavioural measurements; however, these measurements do not give information ...
Wickham, Sarah Louise
core
Repurposing DNA-binding agents as H-bonded organic semiconductors
Nature Communications, 2019 To unlock the potential of biological semiconductors for printed flexible electronics, experimental evidence that reveals the material’s charge transport mechanism is required.
Fengjiao Zhang +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
New Model for Understanding Mechanisms of Biological Signaling: Direct Transport via Cytonemes
, 2016 Biological signaling is a crucial natural process that governs the formation of all multicellular organisms. It relies on efficient and fast transfer of information between different cells and tissues. It has been presumed for a long time that these long-
Teimouri, Hamid, Kolomeisky, Anatoly B.
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