Results 151 to 160 of about 1,751,937 (284)

Conference on Planetary Volatiles [PDF]

Initial and present volatile inventories and distributions in the Earth, other planets, meteorites, and comets; observational evidence on the time history of volatile transfer among reservoirs; and volatiles in planetary bodies, their mechanisms of ...
Oconnell, R., Pepin, R. O.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Nature’s conductors: what can microbial multi-heme cytochromes teach us about electron transport and biological energy conversion?

, 2018
Grace Chong, Amruta Karbelkar, Mohamed Y. El‐Naggar   +2 more
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

In-Situ Biodegradation of Organic Groundwater Contaminants: Delineating the Effect of Physical and Biological Processes by Reactive-Transport Modeling

, 2015
Dominik Eckert
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Eddy-induced iron transport sustains the biological productivity in the Gulf of Alaska [PDF]

Takamitsu Ito, Amanda H. V. Timmerman, Alf Björklund, Samaya I Stanley, Yumi Abe, Christopher T. Reinhard, Joseph P. Montoya   +6 more
openalex   +1 more source

The asphyxiation technique: An approach to distinguishing between molecular diffusion and biologically mediated transport at the sediment—water interface [PDF]

, 1984
Michiel M Rutgers van der Loeff, Leif G. Anderson, Per Hall, Åke Iverfeldt, Alf B. Josefson, BjÅrn Sundby, Stig Westerlund   +6 more
openalex   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Sensitizing Curium Luminescence through an Antenna Protein To Investigate Biological Actinide Transport Mechanisms

, 2013
Manuel Sturzbecher‐Hoehne, Christophe Goujon, Gauthier J.‐P. Deblonde, Anne B. Mason, Rebecca J. Abergel   +4 more
openalex   +2 more sources