Results 101 to 110 of about 4,500,543 (306)

Grounding the Unreal [PDF]

, 2017
The scientific successes of the last 400 years strongly suggest a picture on which our scientific theories exhibit a layered structure of dependence and determination.
Armstrong, Audi, Boolos, Cameron, Corkum, Correia, Della Rocca, deRosset, deRosset, deRosset, deRosset, deRosset, Fine, Fine, Fine, Fine, Fine, Fodor, Jenkins, Kim, Kim, Levine, Lewis, Liggins, Linnebo, Mulligan, Oppenheim, Pereboom, Poggiolesi, Rosen, Schaffer, Schaffer, Schaffer, Sider, Sider, Skiles, Smart, Sydney, Trogdon, Trogdon, Williams, Wilson, Yablo, Yablo   +43 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Cancer-associated fibroblast-induced lncRNA WARS2-IT1 confers radioresistance of colorectal cancer via enhancing HIF-1α stability

Cell Death and Disease
The tumor microenvironment in colorectal cancer (CRC) is marked by a diverse and abundant population of cancer-associated fibroblasts (CAFs), which play a crucial role in radioresistance.
Yuanqi Li, Wei Dai, Xiao Zheng, Qi Wang, Jinping Zhang, Xiangyin Kong, Jingting Jiang, You Zhou   +7 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

TGF-β signaling orchestrates cancer-associated fibroblasts in the tumor microenvironment of human hepatocellular carcinoma: unveiling insights and clinical significance

BMC Cancer
Liver cancer, specifically hepatocellular carcinoma (HCC), stands out as one of the most formidable solid tumors, characterized by a dauntingly low survival rate.
Junwei Ge, Hongwei Jiang, Junjun Chen, Xuemin Chen, Yue Zhang, Liangrong Shi, Xiao Zheng, Jingting Jiang, Lujun Chen   +8 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A Bayesian approach for energy-based estimation of acoustic aberrations in high intensity focused ultrasound treatment [PDF]

, 2018
High intensity focused ultrasound is a non-invasive method for treatment of diseased tissue that uses a beam of ultrasound to generate heat within a small volume. A common challenge in application of this technique is that heterogeneity of the biological
Constanciel, Elodie, Drake, James M., Hosseini, Bamdad, Mougenot, Charles, Pichardo, Samuel, Stockie, John M.   +5 more
core   +2 more sources

Indirect Treatment Comparisons and Biologics [PDF]

The Journal of Allergy and Clinical Immunology: In Practice, 2019
David, Mauger, Andrea J, Apter
openaire   +3 more sources

Biological Methods of Wastewater Treatment

, 2016
This chapter highlights the pros of biological purification methods, such as the possibility to be carried out in situ at the contaminated site, cost efficiency, the ability to regenerate the sorbent, as well as an overall environment friendly character.
Cepoi, L.E., Rudi, L.B., Chiriac, T.V., Codreanu, S.N., Valuţă, A.G.   +4 more
openaire   +2 more sources