Results 181 to 190 of about 4,500,543 (306)

Optimization of ultrasound-electrocatalytic process for improving the quality of biological treatment effluent. [PDF]

Sci Rep
Abdi P, Verdijkazemi K, Nejaei A, Takdastan A.   +3 more
europepmc   +1 more source

The Effect of Biological Treatment on Stress Parameters Determined in Saliva in Patients with Severe Psoriasis. [PDF]

Medicina (Kaunas), 2023
Foks-Ciekalska A, Jarząb J, Hadas E, Świętochowska E, Gumieniak K, Ciekalski W, Bożek A.   +6 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Drug Persistence of Patients with Inflammatory Bowel Disease Under Biological Treatment in the Pre IL-23 Era in a Tertiary Referral Center in Germany. [PDF]

J Clin Med
Farrag K, Grimm L, Dahmer I, Stratmann K, Dienethal A, Sprinzl K, Lande R, Zeuzem S, Blumenstein I, Kubesch A.   +9 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Biological Treatment of Chronic Rhinosinusitis With Polyps Increases Number of Nasal Ciliated Cells-Real-Life Experience. [PDF]

Allergy
Stryjewska-Makuch G, Humeniuk-Arasiewicz M, Onyszczuk M, Kokoszka M, Niemiec-Urbańczyk M, Michalak-Kolarz M, Ścierski W, Gawlik R, Gluck J.   +8 more
europepmc   +1 more source

Case Report: Biological treatment of epidermolysis bullosa acquisita: report on four cases and literature review. [PDF]

Front Immunol, 2023
Szymański K, Kowalewski C, Pietrzyk E, Woźniak K.   +3 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Blood-Count-Derived Inflammatory Biomarkers and Characterization of Super-Responder Profile in Psoriatic Patients Receiving Biological Treatment: A Single-Center Study. [PDF]

Int J Mol Sci
Hołdrowicz A, Zajdel R, Żebrowska A.
europepmc   +1 more source

Tapering of biological treatment in autoinflammatory diseases: a scoping review. [PDF]

Pediatr Rheumatol Online J, 2022
Welzel T, Oefelein L, Twilt M, Pfister M, Kuemmerle-Deschner JB, Benseler SM.   +5 more
europepmc   +1 more source