Results 201 to 210 of about 135,075 (307)

Corrigendum: Factors Associated With PASI90 Maintenance Without Flare-Up and Predictors of Biologics Discontinuation in Psoriasis: Two-Center Retrospective Cohort Study in Korea. [PDF]

Ann Dermatol
Choi MS, Yeom K, Jung SW, Hong SP, Kong KA, Kim MH.   +5 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

394 A tetravalent, pembrolizumab-based fusion immunotherapeutic protein targeting exhausted T cells for expansion and activation

Journal for ImmunoTherapy of Cancer
Zheng Wang, Xiaoyun Zhu, Bai Liu, Lin Kong, Lijing You, Varghese George, Niraj Shrestha, Hamidreza Farzaneh, Lucas Gomez, Christian Echeverri, Jilan Xing, Neicy Gonzalez, Peter R Rhode, Jack O Egan, Hing C Wong   +14 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Update on Pediatric asthma management: Recent advances. [PDF]

Pediatr Allergy Immunol
Dhochak N, Robinson PFM, Saglani S.
europepmc   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Indications for Biological Treatment Combined with Allergen-Specific Immunotherapy: Who Is It Really Intended for? [PDF]

J Clin Med
Turkalj M, Banić I.
europepmc   +1 more source

Pre-clinical development of an enzyme replacement therapy (CPI-601) for CLN1 Batten disease: process development, stability and uptake studies in different species

Neurotherapeutics
Renuka Raman, Ph.D., Ben Horst, Ph.D., Maryam Zare, Ph.D., Zahra Shajrokh, Magdalena Leszczyniecka, Ph.D., Sean Ekins, Ph.D., D.Sc   +5 more
doaj   +1 more source