Results 31 to 40 of about 14,662 (185)

Interaction of lncRNA LENT with DHX36 regulates translation and suppresses autophagy in melanoma

Cell Death and Disease
The melanocyte lineage-determining Microphthalmia-associated transcription factor (MITF) drives proliferation and survival of melanocytic melanoma cells through regulation of both coding genes and long non-coding RNAs (LncRNAs).
Alexandre Haller, Giovanni Gambi, Mattia D’Agostino, Guillaume Davidson, Antonin Lallement, Gabrielle Mengus, Chadia Nahy, Nadia Messaddeq, Guillaume Bec, Angelita Simonetti, Eric Ennifar, Irwin Davidson   +11 more
doaj   +1 more source

Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia

Nature Communications, 2020
Current therapeutic strategies for vitamin D-induced hypercalcemia are poorly efficient. Here the authors identify a new interaction between the vitamin D receptor (VDR) and WBP4 controlling the subcellular localization of VDR and show that ZK168281, a ...
Daniela Rovito, Anna Y. Belorusova, Sandra Chalhoub, Anna-Isavella Rerra, Elvire Guiot, Arnaud Molin, Agnès Linglart, Natacha Rochel, Gilles Laverny, Daniel Metzger   +9 more
doaj   +1 more source

klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis

Nature Communications, 2016
In the developing heart, blood flow transmits mechanical signals to progenitor cells that ultimately leads to valve formation. Here, the authors identify the origin of the valve progenitor cells and fibronectin1bas a transcriptional target of the ...
Emily Steed, Nathalie Faggianelli, Stéphane Roth, Caroline Ramspacher, Jean-Paul Concordet, Julien Vermot   +5 more
doaj   +1 more source

Lipid-depleted diet perturbs membrane composition and intracellular transport in lactating mammary cells

Journal of Lipid Research, 1997
When rats were fed a control or a lipid-depleted diet for five generations, reproduction was not disturbed but pup growth was affected. The membrane organization and the secretory activity of mammary epithelial cells from these lactating rats were ...
M Ollivier-Bousquet, F Lavialle, P Guesnet, D Rainteau, G Durand   +4 more
doaj   +1 more source

Endophytic and ectomycorrhizal, an overlooked dual ecological niche? Insights from natural environments and Russula species

New Phytologist, EarlyView.
Summary Ectomycorrhizal fungi (EcMF) are key components of temperate ecosystems, and recent studies suggest that they can also inhabit non‐EcM plant roots as endophytes. We aimed to (1) provide new evidence of EcMF colonization of non‐EcM hosts, (2) offer direct microscopic confirmation of such endophytism and (3) assess factors influencing ...
Liam Laurent‐Webb, Philippe Rech, Amélia Bourceret, Chloé Chaumenton, Aurélie Deveau, Laurent Genola, Mélanie Januario, Rémi Petrolli, Marc‐André Selosse   +8 more
wiley   +1 more source

Involvement of the Bacillus SecYEG Pathway in Biosurfactant Production and Biofilm Formation

International Journal of Microbiology
With Bacillus species, about 30% of extracellular proteins are translocated through the cytoplasmic membrane, coordinated by the Sec translocase. This system mainly consists of the cytoplasmic ATPase SecA and the membrane-embedded SecYEG channel.
Frédéric Yannick Okouakoua, Christian Aimé Kayath, Saturnin Nicaise Mokemiabeka, David Charles Roland Moukala, Moïse Doria Kaya-Ongoto, Etienne Nguimbi   +5 more
doaj   +1 more source

BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation

Nature Communications, 2016
BTG2 promotes mRNA poly(A) tail shortening and regulates cellular differentiation. Here, Stupfler et al. show that the BTG2 APRO domain interacts with PABPC1 RRM1, allowing the former to recruit and stimulate the poly(A) tail shortening activity of CAF1 ...
Benjamin Stupfler, Catherine Birck, Bertrand Séraphin, Fabienne Mauxion   +3 more
doaj   +1 more source

Comparaison de deux techniques d'identification des souches de levures de vinification basées sur le polymorphisme de l'ADN génomique: réaction de polymérisation en chaine (PCR) et analyse des caryotypes (électrophorèse en champ pulsé)

OENO One, 1994
Une nouvelle technique de la biologie moléculaire, la réaction de polymérisation en chaine (PCR) permet l'identification des souches de levures de vinification.
Isabelle Masneuf-Pomarède, Denis Dubourdieu   +1 more
doaj   +1 more source

TopoDoE: a design of experiment strategy for selection and refinement in ensembles of executable gene regulatory networks

BMC Bioinformatics
Background Inference of Gene Regulatory Networks (GRNs) is a difficult and long-standing question in Systems Biology. Numerous approaches have been proposed with the latest methods exploring the richness of single-cell data.
Matteo Bouvier, Souad Zreika, Elodie Vallin, Camille Fourneaux, Sandrine Gonin-Giraud, Arnaud Bonnaffoux, Olivier Gandrillon   +6 more
doaj   +1 more source