Results 31 to 40 of about 496,953 (167)

Distinct Molten‐Globule Conformations in an Interacting Protein Domain Resolved by 19F NMR of Fluoroproline Residues

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Modifying the conformational ensemble of “molten‐globule” protein by the site‐specific incorporation of stereoisomeric 4‐fluoroproline residues modulated its binding affinity and aggregation behavior. 19F NMR spectroscopy enabled the detection of key interactions responsible for structural and dynamic changes. ABSTRACT Recently, the application of deep
Abir Ben Bouzayene, Mariam Sai, Alexis Jouin, Yves Nominé, Vladimir Torbeev, Bruno Kieffer   +5 more
wiley   +2 more sources

Cross‐Linking Mass Spectrometry of the Antimicrobial Peptides Magainin 2 and PGLa Reveals Heterodimerization in Micellar Medium

Rapid Communications in Mass Spectrometry, EarlyView.
ABSTRACT Rationale In this study, we applied cross‐linking mass spectrometry (XL‐MS) to characterize the oligomeric states of a PGLa/magainin 2 mixture and gain insight into the heterodimerization previously suggested in the literature. Both peptides have shown a synergistic enhancement of activity when tested in antimicrobial assays; however, the ...
Emilie Hirschler, Elise Glattard, Nicolas Arnaud, Johana Chicher, Philippe Hammann, Emmanuelle Leize‐Wagner, Burkhard Bechinger, Noelle Potier   +7 more
wiley   +1 more source

Mechanism‐Guided Engineering of Upconversion Nanoparticles for Antibacterial Phototherapy: From Photonic Principles to Translational Nanosystems

Small, EarlyView.
This review provides a systematic overview of the field of antibacterial PhotoDynamic Therapy (aPDT) triggered by upconversion nanoparticles (UCNPs), focusing on the mechanisms and the key factors that define their efficacy for generating bactericidal species upon NIR‐light activation.
Zhe Li, Calum Johnston, Barbara Lonetti, Clément Roux   +3 more
wiley   +1 more source

Hi-D: nanoscale mapping of nuclear dynamics in single living cells

Genome Biology, 2020
Bulk chromatin motion has not been analyzed at high resolution. We present Hi-D, a method to quantitatively map dynamics of chromatin and abundant nuclear proteins for every pixel simultaneously over the entire nucleus from fluorescence image series.
Haitham A. Shaban, Roman Barth, Ludmila Recoules, Kerstin Bystricky   +3 more
doaj   +1 more source

Context‐Dependent Radioenhancement by Platinum Nanoparticles Under Conventional and Ultra‐High Dose‐Rate “FLASH” Radiotherapy

Small, EarlyView.
Overview of the experimental workflow and main findings of the study investigating Pt‐NPs‐mediated radioenhancement under conventional 134 dose‐rate (CONV) and ultrahigh dose‐rate (UHDR) 9 MeV electron irradiation. Pt‐NP distribution and uptake were characterized in 4T1 spheroids and syngeneic tumor models.
Cathyanne Schott, Foutina Feghali, Marine Gerbé de Thoré, Amina Joudat, Lydia Meziani, Aashini Rajpal, Winchygn Liu, Tudor Manoliu, Farah Savina, Sandrine Lacombe, Eric Deutsch, Julie Colnot, Charlotte Robert, Erika Porcel, Pauline Maury   +14 more
wiley   +1 more source

Interaction of lncRNA LENT with DHX36 regulates translation and suppresses autophagy in melanoma

Cell Death and Disease
The melanocyte lineage-determining Microphthalmia-associated transcription factor (MITF) drives proliferation and survival of melanocytic melanoma cells through regulation of both coding genes and long non-coding RNAs (LncRNAs).
Alexandre Haller, Giovanni Gambi, Mattia D’Agostino, Guillaume Davidson, Antonin Lallement, Gabrielle Mengus, Chadia Nahy, Nadia Messaddeq, Guillaume Bec, Angelita Simonetti, Eric Ennifar, Irwin Davidson   +11 more
doaj   +1 more source

klf2a couples mechanotransduction and zebrafish valve morphogenesis through fibronectin synthesis

Nature Communications, 2016
In the developing heart, blood flow transmits mechanical signals to progenitor cells that ultimately leads to valve formation. Here, the authors identify the origin of the valve progenitor cells and fibronectin1bas a transcriptional target of the ...
Emily Steed, Nathalie Faggianelli, Stéphane Roth, Caroline Ramspacher, Jean-Paul Concordet, Julien Vermot   +5 more
doaj   +1 more source

Comparaison de deux techniques d'identification des souches de levures de vinification basées sur le polymorphisme de l'ADN génomique: réaction de polymérisation en chaine (PCR) et analyse des caryotypes (électrophorèse en champ pulsé)

OENO One, 1994
Une nouvelle technique de la biologie moléculaire, la réaction de polymérisation en chaine (PCR) permet l'identification des souches de levures de vinification.
Isabelle Masneuf-Pomarède, Denis Dubourdieu   +1 more
doaj   +1 more source

Non-proteolytic ubiquitylation in cellular signaling and human disease

Communications Biology, 2022
Evanthia Pangou and co-authors review recent insights into the important roles of non-proteolytic ubiquitylation in cellular signaling as well as in physiology and disease.
Yongrong Liao, Izabela Sumara, Evanthia Pangou   +2 more
doaj   +1 more source

Effect of the microbiome on pathogen susceptibility across four Drosophilidae species

Insect Science, EarlyView.
Four Drosophilidae species were used to investigate how variation in the host microbiome influences susceptibility to infection. Microbial composition and abundance differed among species and treatments. The effects of microbiome manipulation on host survival were both species‐ and pathogen‐specific.
Hongbo Sun, Ben Longdon, Ben Raymond
wiley   +1 more source