Results 41 to 50 of about 496,953 (167)

Involvement of the Bacillus SecYEG Pathway in Biosurfactant Production and Biofilm Formation

International Journal of Microbiology
With Bacillus species, about 30% of extracellular proteins are translocated through the cytoplasmic membrane, coordinated by the Sec translocase. This system mainly consists of the cytoplasmic ATPase SecA and the membrane-embedded SecYEG channel.
Frédéric Yannick Okouakoua, Christian Aimé Kayath, Saturnin Nicaise Mokemiabeka, David Charles Roland Moukala, Moïse Doria Kaya-Ongoto, Etienne Nguimbi   +5 more
doaj   +1 more source

BTG2 bridges PABPC1 RNA-binding domains and CAF1 deadenylase to control cell proliferation

Nature Communications, 2016
BTG2 promotes mRNA poly(A) tail shortening and regulates cellular differentiation. Here, Stupfler et al. show that the BTG2 APRO domain interacts with PABPC1 RRM1, allowing the former to recruit and stimulate the poly(A) tail shortening activity of CAF1 ...
Benjamin Stupfler, Catherine Birck, Bertrand Séraphin, Fabienne Mauxion   +3 more
doaj   +1 more source

Lipid-depleted diet perturbs membrane composition and intracellular transport in lactating mammary cells

Journal of Lipid Research, 1997
When rats were fed a control or a lipid-depleted diet for five generations, reproduction was not disturbed but pup growth was affected. The membrane organization and the secretory activity of mammary epithelial cells from these lactating rats were ...
M Ollivier-Bousquet, F Lavialle, P Guesnet, D Rainteau, G Durand   +4 more
doaj   +1 more source

Cytosolic sequestration of the vitamin D receptor as a therapeutic option for vitamin D-induced hypercalcemia

Nature Communications, 2020
Current therapeutic strategies for vitamin D-induced hypercalcemia are poorly efficient. Here the authors identify a new interaction between the vitamin D receptor (VDR) and WBP4 controlling the subcellular localization of VDR and show that ZK168281, a ...
Daniela Rovito, Anna Y. Belorusova, Sandra Chalhoub, Anna-Isavella Rerra, Elvire Guiot, Arnaud Molin, Agnès Linglart, Natacha Rochel, Gilles Laverny, Daniel Metzger   +9 more
doaj   +1 more source

Comprehensive prospective investigation of splicing variants in the coding region of RHD: Insights into phenotypic consequences including revision of RHD*weak D type 3

British Journal of Haematology, EarlyView.
Summary As splicing has been shown to be commonly altered by single nucleotide variants (SNVs) in the RHD gene, resulting in a mild to severe drop in the expression of the D antigen, we sought to identify prospectively those deleterious SNVs that may disrupt splicing. All potential substitutions affecting the coding deoxyribonucleic acid (DNA) sequence
Yann Fichou, Christophe Tournamille, Gauthier Thomas, Cyriel Plaire, Aurélie Barrault, Nadège Marec, Pierre Pochard, Caroline Bénech, Aline Floch   +8 more
wiley   +1 more source

TopoDoE: a design of experiment strategy for selection and refinement in ensembles of executable gene regulatory networks

BMC Bioinformatics
Background Inference of Gene Regulatory Networks (GRNs) is a difficult and long-standing question in Systems Biology. Numerous approaches have been proposed with the latest methods exploring the richness of single-cell data.
Matteo Bouvier, Souad Zreika, Elodie Vallin, Camille Fourneaux, Sandrine Gonin-Giraud, Arnaud Bonnaffoux, Olivier Gandrillon   +6 more
doaj   +1 more source

Senescence controls prostatic neoplasia driven by Pten loss

Molecular & Cellular Oncology, 2019
We report that Pten (phosphatase and tensin homologue) ablation in prostatic epithelial cells of adult mice promotes cell proliferation to generate prostatic intraepithelial neoplasia.
Maxime Parisotto, Elise Grelet, Rana El Bizri, Daniel Metzger   +3 more
doaj   +1 more source

Comparison of the life cycles of two populations of the polychaete Pereinereis cf. cultrifera from the Bay of Algiers (Mediterranean Sea)

Scientia Marina, 2008
The benthic phases of the life cycles of two populations of the polychaete Pereinereis cultrifera from the Bay of Algiers were investigated using field surveys. We found no differences in the life cycle of the two populations.
Leila Rouabah, Abdelkader Rouabah, Sana Ferroudj, Patrick Scaps   +3 more
doaj   +1 more source

Basophilic Stippling Unmasks Pyrimidine 5′‐Nucleotidase Deficiency in a G6PD‐Deficient Patient

American Journal of Hematology, EarlyView.
Victor Bobée, Stéphane Moutereau, Maïssa Souissi, Pierre Lebreton, Loïc Garcon   +4 more
wiley   +1 more source

Interaction with NEGR1 affects mGlu5 cell signalling and the neuroprotection induced by the positive allosteric modulator VU0409551

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The metabotropic glutamate receptor mGlu5 plays an important role in neuronal survival and synaptic plasticity. We and others have shown that mGlu5 positive allosteric modulators (PAMs) are biased agonists, triggering the activation of neuroprotective pathways and promoting neuronal survival. As mGlu5 biased pharmacology
Jennifer D. S. Guimaraes, Toniana G. Carvalho, Luan A. Pereira, Emanuele G. Silva, Esther M. A. Maciel, Gabriella P. Torres, Thiago Assis, Pablo L. Cardozo, Joao P. P. de Almeida, Nathalia C. Silva, Francesca Pischedda, Giovanni Piccoli, Luciene B. Vieira, Juliana Alves‐Silva, Fabiola M. Ribeiro   +14 more
wiley   +1 more source