Results 41 to 50 of about 13,847 (134)

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Relation entre hématocrite-anémie et état d’infection trypanosomienne: cas du bétail N’Dama au ranch de Mushie en RDC

Revue Marocaine des Sciences Agronomiques et Vétérinaires, 2019
Une étude a été menée au secteur Izeli du ranch de Mushie (Province de Maï-Ndombe) en République Démocratique du Congo du 3 Août au 5 Septembre 2014 et du 6 Février au 7 Mars 2015.
Edouard Telamanu BAFWANGA, Anicet Ilaka NZASHILUMENGU, Arthur NGULU-NSASI, Willy Kabamba MWAMBA   +3 more
doaj  

Senescence controls prostatic neoplasia driven by Pten loss

Molecular & Cellular Oncology, 2019
We report that Pten (phosphatase and tensin homologue) ablation in prostatic epithelial cells of adult mice promotes cell proliferation to generate prostatic intraepithelial neoplasia.
Maxime Parisotto, Elise Grelet, Rana El Bizri, Daniel Metzger   +3 more
doaj   +1 more source

Multilevel genomic constraints shape nuclear tRNA gene organization in plants

The Plant Journal, Volume 127, Issue 3, August 2026.
SUMMARY Transfer RNAs (tRNAs) are essential components of the translation machinery. Their abundance and diversity shape decoding capacity as well as the efficiency and accuracy of protein synthesis. Because tRNA abundance is encoded in the genome through tDNA copy number, chromosomal organization, and cis‐regulatory sequences controlling transcription,
Guillaume Hummel, David Pflieger, Valérie Cognat, Laurence Drouard, Alexandre Berr   +4 more
wiley   +1 more source

NimA promotes cell adhesion at the blood brain barrier of the Drosophila nervous system

EMBO Reports
Glial cells are crucial for nervous system development and function by clearing debris, protecting neurons and ensuring neuronal survival. In Drosophila, glia form the blood–brain barrier, which regulates neural stem cell proliferation and shields the ...
Rosy Sakr, Sara Monticelli, Smrithi Kizhakkenottiyath Shasthadevan, Claude Delaporte, Gege Zhang, Tarek Tabiat, Angela Giangrande, Pierre B Cattenoz   +7 more
doaj   +1 more source

Single cell transcriptomics reveal trans-differentiation of pancreatic beta cells following inactivation of the TFIID subunit Taf4

Cell Death and Disease, 2021
Regulation of gene expression involves a complex and dynamic dialogue between transcription factors, chromatin remodelling and modification complexes and the basal transcription machinery.
Thomas Kleiber, Guillaume Davidson, Gabrielle Mengus, Igor Martianov, Irwin Davidson   +4 more
doaj   +1 more source

Cationic Permethylated Cyclodextrins Capable of Self‐Assembling Into Linear Nanostructures in Water

Chemistry – A European Journal, Volume 32, Issue 25, 2 July 2026.
A quaternary ammonium bridge equipped with a lipophilic substituent in permethylated cyclodextrins suppresses undesired supramolecular interactions and promotes controlled, directional head‐to‐tail self‐assembly into well‐defined linear nanostructures.
Maxime Kolb, Marvin Benjaffel, Peter Faller, Laurent Raibaut, Dominique Armspach   +4 more
wiley   +1 more source

A muscular dystrophy associated with bi‐allelic LEMD2 variants: Expanding the genotype of nuclear envelopathies

Brain Pathology, Volume 36, Issue 4, July 2026.
Proteomics‐guided exome re‐analysis identifies bi‐allelic variants in the nuclear envelope LEMD2 gene, expanding its phenotypic spectrum. Created in BioRender. Pauper, M. (2026) https://BioRender.com/xamvo92.
Marc Pauper, Heike Kölbel, Iakowos Karakesisoglou, Anne Schänzer, Johann Böhm, Rachel Thompson, Nicolai Kohlschmidt, Bernd Ringel, Gisèle Bonne, Katja Neuhoff, Andrea Gangfuß, Ozge Aksel Kilicarslan, Sergi Beltran Agullo, Andreas Hentschel, Ulrike Schara‐Schmidt, Hanns Lochmüller, Kiran Polavarapu, Andreas Roos   +17 more
wiley   +1 more source

Standardized Pipeline for Metabolism and Cognition in GO‐DS21 Mouse Model: Investigating Down Syndrome Comorbidities

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract Down syndrome (DS) is the most prevalent form of intellectual disability (ID) globally, with an incidence rate of approximately 1 in 1000 births, affecting over 5 million individuals worldwide. DS is characterized by a genetic profile that predisposes individuals to a range of medical and cognitive conditions, including ID and obesity, which ...
Mohammed Selloum, Patricia da Silva‐Buttkus, Fabrice Riet, Nathalia R. V. Dragano, Lillian Garrett, Hugues Jacobs, Sabine M. Hölter, Nicolas Torquet, Birgit Rathkolb, Loic Lindner, Valerie Gailus‐Durner, Guillaume Pavlovic, Li Chan, Johannes Beckers, Benoit Petit Demoulière, Helmut Fuchs, Elodie Ey, Tania Sorg, Martin Hrabe de Angelis, Yann Herault, the GO‐DS21 Consortium   +20 more
wiley   +1 more source

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling

Glia, Volume 74, Issue 6, June 2026.
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro, Quentin Brassart, Valérie Fraulob, Laura Calzà, Wojciech Krezel   +4 more
wiley   +1 more source