Results 31 to 40 of about 349,804 (205)

Age-related and disease locus-specific mechanisms contribute to early remodelling of chromatin structure in Huntington’s disease mice

Nature Communications, 2021
The dynamics of chromatin and transcriptional changes underlying Huntington’s disease remain poorly understood. Here the authors use a Huntington’s mouse model to profile the striatal chromatin landscape, finding that the Huntington’s mutation ...
Rafael Alcalá-Vida, Jonathan Seguin, Caroline Lotz, Anne M. Molitor, Ibai Irastorza-Azcarate, Ali Awada, Nezih Karasu, Aurélie Bombardier, Brigitte Cosquer, Jose Luis Gomez Skarmeta, Jean-Christophe Cassel, Anne-Laurence Boutillier, Thomas Sexton, Karine Merienne   +13 more
doaj   +1 more source

Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics (GFCH)

American Journal of Hematology, EarlyView.
ABSTRACT Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a ...
Florence Nguyen‐Khac, Audrey Bidet, Elise Chapiro, Nathalie Douet‐Guilbert, Jean‐Baptiste Gaillard, Nada Assaf, Nathalie Auger, Hend Chaker, Jasmine Chauzeix, Inge Govaerts, Hippolyte Guérineau, Christine Lefebvre, Pauline Roynard, Hélène Guermouche, Lucienne Michaux, Marie‐Bérengère Troadec, Lauren Véronèse   +16 more
wiley   +1 more source

Artrose; van diversiteit in moleculaire paden tot effectieve therapie op maat [PDF]

, 2018
Oratie uitgesproken door Prof.dr. I. Meulenbelt bij de aanvaarding van het ambt van hoogleraar op het gebied van Moleculaire Biologie van Artrose aan de Universiteit Leiden op vrijdag 19 januari 2018Oratie uitgesproken door Prof.dr. I.
Meulenbelt, I.
core  

Mise en évidence de la reproduction naturelle du saumon atlantique (Salmo salar L.) dans un affluent français du Rhin par analyse génétique d'oeufs prélevés dans des frayères

Knowledge and Management of Aquatic Ecosystems, 1996
En utilisant la réaction de polymérisation en chaîne, nous avons pu amplifier des régions spécifiques des ADN nucléaire (région conservée des gènes du rARN 5S) et mitochondrial (région ND-5/6) extraits d'oeufs prélevés sur quatre frayères de salmonidés ...
LARGIADER C. R., GUYOMARD R., ROCHE P.
doaj   +1 more source

Extreme Gradient Boosting Tuned with Metaheuristic Algorithms for Predicting Myeloid NGS Onco-Somatic Variant Pathogenicity

Bioengineering, 2023
The advent of next-generation sequencing (NGS) technologies has revolutionized the field of bioinformatics and genomics, particularly in the area of onco-somatic genetics.
Eric Pellegrino, Clara Camilla, Norman Abbou, Nathalie Beaufils, Christel Pissier, Jean Gabert, Isabelle Nanni-Metellus, L’Houcine Ouafik   +7 more
doaj   +1 more source

Synthesis and Structures of Novel Chiral Cyclic Hypervalent Iodine(III) Reagents for Metal‐Free Ligand‐Transfer Reactions

Chemistry – A European Journal, EarlyView.
Several new chiral cyclic hypervalent iodine(III) reagents have been synthesized and characterized. Carbon‐based ligands were successfully installed onto the hypervalent iodine centers, giving thus access to novel chiral cyano‐, trifluoromethyl‐ or alkynyl‐bearing λ3‐iodanes.
Emmanuel Valzer, Jean‐Marc Sotiropoulos, Karinne Miqueu, Laurent Pouységu, Stéphane Quideau   +4 more
wiley   +1 more source

Distinct Molten‐Globule Conformations in an Interacting Protein Domain Resolved by 19F NMR of Fluoroproline Residues

Angewandte Chemie, Volume 138, Issue 42, 12 October 2026.
Modifying the conformational ensemble of “molten‐globule” protein by the site‐specific incorporation of stereoisomeric 4‐fluoroproline residues modulated its binding affinity and aggregation behavior. 19F NMR spectroscopy enabled the detection of key interactions responsible for structural and dynamic changes. ABSTRACT Recently, the application of deep
Abir Ben Bouzayene, Mariam Sai, Alexis Jouin, Yves Nominé, Vladimir Torbeev, Bruno Kieffer   +5 more
wiley   +2 more sources

NUTRITION Acides gras polyinsaturés de microalgues : intérêts et développements actuels

Oléagineux, Corps gras, Lipides, 2002
Commercialisés comme compléments nutritionnels sous forme de capsules ou utilisés comme ingrédients pour la préparation de lait maternisé, les acides gras polyinsaturés (AGPI) de la série ôméga3 sont principalement obtenus à partir d’huiles de poisson ...
Poisson Laurent, Devos Marie, Pencreac’h Gaëlle, Ergan Françoise   +3 more
doaj   +1 more source

Le bébé collodion: aspects cliniques et intérêt du diagnostic anténatal

The Pan African Medical Journal, 2017
Le bébé collodion est une forme sévère de l'ichtyose congénitale à révélation néonatale. Le tableau clinique est souvent caractéristique. L'évolution, quand elle n'est pas fatale, se fait le plus souvent vers l'ichtyose sèche.
Ridha Fatnassi, Nédia Marouen, Houcem Ragmoun, Latifa Marzougui, Sabra Hammami   +4 more
doaj   +1 more source

Plasma Lipid Remodeling across Preclinical Burden, Disease Onset, and Early Motor Severity in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background and Objectives Huntington's disease (HD) evolves silently for years before motor onset, yet the systemic metabolic alterations accompanying cumulative exposure to mutant huntingtin and disease progression remain poorly understood.
Mohamed Bendimerad, Dominique Bonneau, Clarisse Scherer‐Gagou, Adriana Prundean, Karim Chikh, Oriane Vitalis, Audrey Olivier, Odile Blanchet, Judith Nzoughet‐Kouassi, Christophe Verny, Pascal Reynier, Juan Manuel Chao de la Barca   +11 more
wiley   +1 more source