Results 51 to 60 of about 907,769 (296)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Biology by Numbers—Introducing Quantitation into Life Science Education

PLoS Biology, 2005
An online educational module introduces students to concepts of quantitation and numerical simulations in developmental ...
Aegerter-Wilmsen, T., Bisseling, T.
openaire   +5 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Essay Competency-Based Reforms of the Undergraduate Biology Curriculum: Integrating the Physical and Biological Sciences

, 2013
Hughes Medical Institute is a direct response to the Scientific Foundations for Future Physicians re-port, which urged a shift in premedical student preparation from a narrow list of specific course work to a more flexible curriculum that helps students ...
Gaines, Michael S, LaCourse, William R, Katerina V. Thompson, Jean Chmielewski, Christine A. Hrycyna, Thompson, Katerina V, William R. Lacourse, Michael S. Gaines, Chmielewski, Jean, Hrycyna, Christine A   +9 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Preface: The 2nd International Electronic Conference on Microbiology

Biology and Life Sciences Forum
This volume of the Biology and Life Sciences Forum assembles the articles presented at the 2nd International Electronic Conference on Microbiology (ECM 2023) [...]
Nico Jehmlich
doaj   +1 more source

The Circadian Clock Protein CRY1 Is a Negative Regulator of HIF-1α

iScience, 2019
Summary: The circadian clock and the hypoxia-signaling pathway are regulated by an integrated interplay of positive and negative feedback limbs that incorporate energy homeostasis and carcinogenesis.
Elitsa Y. Dimova, Mirza Jakupovic, Kateryna Kubaichuk, Daniela Mennerich, Tabughang Franklin Chi, Filippo Tamanini, Małgorzata Oklejewicz, Jens Hänig, Nadiya Byts, Kari A. Mäkelä, Karl-Heinz Herzig, Peppi Koivunen, Ines Chaves, Gijsbertus van der Horst, Thomas Kietzmann   +14 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Educational Challenges of Molecular Life Science- Characteristics and implications for education and research

, 2010
Molecular life science is one of the fastest-growing fields of scientific and technical innovation, and biotechnology has profound effects on many aspects of daily life, often with deep ethical dimensions.
Tibell, Lena A. E.,, Rundgren, Carl-Johan A., Rundgren, Carl-Johan A.,, Tibell, Lena A. E.   +3 more
core   +1 more source