Results 101 to 110 of about 481,378 (312)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Designing and testing an MI-based interactive web platform: Enhancing biological concept understanding and multiple intelligence development

JPBI (Jurnal Pendidikan Biologi Indonesia)
Conventional biology teaching methods often do not address the diversity of learning styles and students' multiple intelligences. The study aims to investigates the effectiveness of an interactive web platform, grounded in the theory of multiple ...
Risya Pramana Situmorang, Martha Eka Latelay, Dujun Durinam Selan   +2 more
doaj   +1 more source

Biology - Stage 2: Laboratory Rules

, 2011
The Institute for Adult Education in Tanzania developed a Multimedia Strategy to assist them to achieve its Mission ‘to design and implement quality adult and continuing education and training programmes that will enable its learners to acquire knowledge

core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Teachers' view on the relationship between outdoor environmental education and a sense of place

, 2012
   In an era of globalization and urbanization, various social, economic, and environmental challenges surround advances in modern biological sciences. Considering how biological knowledge and practice are intrinsically related to building a sustainable ...
Fägerstam, Emilia,
core   +2 more sources

Integration of religious values in biology learning and its implications for students' environmental awareness

JPBI (Jurnal Pendidikan Biologi Indonesia)
Environmental degradation necessitates educational strategies that not only enhance cognitive understanding but also cultivate students’ spiritual and moral character.
F. Fitriana, Hafnati Rahmatan, E. Evendi, S. Saminan, M. Mentari   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Biology - Stage 2: Process of Life

, 2011
The Institute for Adult Education in Tanzania developed a Multimedia Strategy to assist them to achieve its Mission ‘to design and implement quality adult and continuing education and training programmes that will enable its learners to acquire knowledge

core  

Fieldwork-Orientated Biology Teachers' Views on Outdoor Education [PDF]

, 2018
Outdoor environments are considered as important learning environments in biology education. Previous studies on outdoor education and fieldwork indicate many positive impacts on students’ cognitive and affective achievements.
Kervinen, Anttoni, Juuti, Kalle, Uitto, Anna   +2 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source