Results 91 to 100 of about 19,142,092 (295)

Systems biology in animal sciences [PDF]

, 2011
Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
Pas, M.F.W., te, M.A. Smits, Veerkamp, R.F., Woelders, H., Bannink, A., M.F.W. Te Pas, Pas, M., R.F. Veerkamp, Smits, M.A., H. Woelders, A. Bannink, te Pas, M.F.W.   +11 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Effects of TPACK-based instruction on secondary school students’ biology achievement and perception in education district VI, Lagos State

International Journal of Studies in Psychology
Biology education increasingly demands innovative approaches that integrate technology, pedagogy, and content to address students’ diverse learning needs.
Iskeel Sina Raheem
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

THE EFFECTIVENESS OF THE APPLICATION OF THE METHODOLOGY OF PROJECT-BASED LEARNING IN GENERAL BIOLOGY IN THE FORMATION OF STUDENTS' SUBJECT AND META-SUBJECT COMPETENCIES

Russian Journal of Education and Psychology
Background. The system-activity approach as the methodological basis of modern educational standards has determined the need to involve schoolchildren in project activities at all levels of general education in accordance with the principle of continuity
Andzhelika M. Shekhmirzova, Lyudmila V. Gribina, Fatima A. Tuguz, Nafiset S. Blagoz   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Chemical Biology Gateways to Mapping Location, Association, and Pathway Responsivity

Frontiers in Chemistry, 2019
Here we discuss, how by applying chemical concepts to biological problems, methods have been developed to map spatiotemporal regulation of proteins and small-molecule modulation of proteome signaling responses.
Marcus J. C. Long, Xuyu Liu, Yimon Aye
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

TarO : a target optimisation system for structural biology [PDF]

, 2008
This work was funded by the UK Biotechnology and Biological Sciences Research Council (BBSRC) Structural Proteomics of Rational Targets (SPoRT) initiative, (Grant BBS/B/14434).
Naismith, Jim, Barton, Geoffrey J, Naismith, James H, William N. Hunter, White, Malcolm F, McMahon, Stephen, Hunter, William N., vanNiekerk, C. A. Johannes, Overton, Ian M., Hunter, William, van Niekerk, C. A. Johannes, van Niekerk, C A, Barton, Geoffrey, Carter, Lester, Geoffrey J. Barton, Naismith, James, Hunter, W N, Carter, Lester G., Overton, Ian; id_orcid, Dawson, Alice, McMahon, S A, Dawson, A, David M. A. Martin, McMahon, Stephen A., White, Malcolm F., Martin, David, Scott Cameron, White, Malcolm, Barton, G J, Cameron, Scott, Naismith, James H., Ian M. Overton, James H. Naismith, Cameron, S, Malcolm F. White, Barton, Geoffrey J.; id_orcid, Lester G. Carter, Carter, L G, Alice Dawson, Martin, D M, Martin, David M. A.; id_orcid, C. A. Johannes Van Niekerk, Stephen A. Mcmahon, Overton, I M, Overton, Ian   +44 more
core   +1 more source