Results 91 to 100 of about 20,738,755 (301)
The Scottish Structural Proteomics Facility : targets, methods and outputs [PDF]
, 2010 The Scottish Structural Proteomics Facility was funded to develop a laboratory scale approach to high throughput structure determination. The effort was successful in that over 40 structures were determined.Garrett, Roger A., Barton, Geoffrey J, Mark Dorward (10196177), Prangishvili, D, Muse Oke (452182), Schwarz-Linek, Ulrich, Xu Peng, Melina Kerou (6987863), Catherine H Botting (16216415), James H Naismith (16216433), Prangishvili, D. A., Prakash Patel (594463), David T F Dryden (16216421), Johannes van Niekerk, C. A., C A Johannes van Niekerk (16216409), Carter, Lester G., Taylor, Garry L, Md Arif Sheikh (16216349), Dorward, M, Michal Zawadzki, McMahon, Stephen A., Sheikh, Md Arif, Kerou, Melina, Challis, GL, Muse Oke, Carter, LG, Weikart, Nadine D., James H. Naismith, Oke, M, Challis, Gregory L, McMahon, Stephen A, Yan, X, Malcolm F. White, Xuan Yan (4844139), Liu, Huanting, Melina Kerou, Weikart, Nadine D, van Niekerk, CA, Peter J. Coote, Botting, Catherine H., Michal Zawadzki (11327080), Taylor, GL, David T. F. Dryden, Nadia Kadi (2425486), Prangishvili, David, Sheikh, Md. Arif, Naismith, JH, Schwarz-Linek, Uli, Yan, Xuan, Ulrich Schwarz-Linek, Kadi, N, Coote, Peter J., White, MF, Stephen A. McMahon, Weikart, ND, Carter, Lester G, Kenneth A Johnson (16216388), White, Malcolm F., Overton, IM, Garrett, Roger A, Schmelz, Stefan, Mark Dorward, Kadi, Nadia, Nadia Kadi, Naismith, James H., Liu, H, Garry L Taylor (16216352), Dryden, DT, McMahon, SA, Xuan Yan, Coote, PJ, Niekerk, C. A. Johannes, Lester G. Carter, Zawadzki, M, Overton, Ian M.; id_orcid, Gregory L. Challis, Geoffrey J Barton (16216424), Gregory L Challis (16216427), Ian M Overton (16216406), White, Malcolm F, Lester G Carter (16208402), Stephen A McMahon (16216391), van Niekerk, C A Johannes, Dryden, David T F, Falconer, Helen, Cozens, Christopher, Patel, Prakash, Geoffrey J. Barton, Md. Arif Sheikh, Peng, X, Botting, Catherine H, Barton, Geoffrey J; id_orcid, Roger A Garrett (16216412), Ulrich Schwarz-Linek (5801099), Johnson, KA, Falconer, H, Dorward, Mark, Barton, Geoffrey J., Xu Peng (365714), Huanting Liu (3691537), Peng, Xu, Sheikh, MA, Oke, Muse, Powers, H, Helen Falconer, Nadine D. Weikart, Dryden, David T. F., Prakash Patel, Powers, Helen, Naismith, James H, Malcolm F White (16216430), Kenneth A. Johnson, Taylor, Garry L., Overton, Ian M., Schmelz, S, Catherine H. Botting, Helen Falconer (16216400), Coote, Peter J, Johnson, Kenneth A, Botting, CH, Stefan Schmelz, Kerou, M, Barton, GJ, David Prangishvili (22095), Johnson, Kenneth A., Zawadzki, Michal, Christopher Cozens, David Prangishvili, Nadine D Weikart (16216394), C. A. Johannes van Niekerk, Overton, Ian M, Christopher Cozens (5232944), Garrett, Roger Antony, Peter J Coote (16216418), Challis, Gregory L., Ian M. Overton, Roger A. Garrett, Garrett, RA, Cozens, C, Garry L. Taylor, Helen Powers (16216403), Stefan Schmelz (16216397), Helen Powers, Huanting Liu, Patel, P, White, MF; id_orcid, Taylor, GL; id_orcid, Schwarz-Linek, Uli; id_orcid, Coote, PJ; id_orcid +148 morecore +1 more sourceLiver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses Anna M. Dowbaj, Meritxell Huchwiley +1 more sourcePartial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig +10 morewiley +1 more sourceData publication with the structural biology data grid supports live analysis. [PDF]
, 2015 International audienceAccess to experimental X-ray diffraction image data is fundamental for validation and reproduction of macromolecular models and indispensable for development of structural biology processing methods.Fraser, James S., Harrison, Stephen C.,, Diederichs, Kay, Di Cera, Enrico, Petosa, Carlo,, Garcia, K Christopher, Bonvin, Alexandre M. J. J., Wu, Hao, Blacklow, Stephen C, Neau, David, Modis, Yorgo, Raman, C S, Raman, S., Kvansakul, Marc, Fan, Qing R.,, Diederichs, Kay,, Blacklow, Stephen C.,, Chazin, Walter J., Lei, Ming, Caflisch, Amedeo, Christopher Fromme, J, Raman, S.,, Corbett, Kevin D., Bonvin, Alexandre M.J.J., Tsodikov, Oleg V., Brett, Tom J.,, Meyer, Peter A.,, Roll-Mecak, Antonina, Sub NMR Spectroscopy, Tjon, Emily C., Gong, Peng, Foster, Ian, Heldwein, Ekaterina E, Boggon, Titus J.,, Chang, Chung-I,, Tjon, Emily C, Ferre-D'Amare, Adrian R.,, Crosson, Sean, Schwartz, Thomas U, Botka, Chris,, Anderson, Karen S, Nam, Yunsun,, Chang, Chung-I, Meyer, Peter A., Roll-Mecak, Antonina,, Borek, Dominika, Rudenko, Gabby,, Crosson, Sean,, Botka, Chris, Neau, David,, Maia, Filipe R. N. C., Eck, Michael J.,, Key, Jason, Corbett, Kevin D, Maia, Filipe RNC, Garcia, K.Christopher, Kirchhausen, Tom,, Kruse, Andrew C., Jia, Zongchao,, Meyer, Peter A, Kirchhausen, Tom, Baxter, Richard H, McLellan, Jason S, Rosen, Michael K, Kruse, Andrew C, Westover, Kenneth D.,, Eck, Michael J, Anderson, Karen S.,, Schwartz, Thomas U.,, Tao, Yizhi J.,, Rapoport, Tom A, Buschiazzo, Alejandro, Maia, Filipe R.N.C., Withrow, James,, Ransey, Elizabeth, Boggon, Titus J., Pai, Emil F, Crosas, Merce,, Schwartz, Thomas U., Gonen, Tamir,, Drennan, Catherine L., Gonen, Tamir, Tao, Yizhi Jane, Eichman, Brandt F.,, Rudenko, Gabby, Drennan, Catherine L.,, Socias, Stephanie,, Kvansakul, Marc,, Harrison, Stephen C, Anderson, Karen S., Schlessinger, Joseph,, Keenan, Robert J, Rajashankar, Kanagalaghatta, Maia, Filipe R. N. C.,, Heldwein, Ekaterina E., Baxter, Richard H., Fraser, James S, Fromme, J. Christopher, Dhe-Paganon, Sirano,, Tao, Yizhi J, Fromme, J.Christopher, Otwinowski, Zbyszek, Caflisch, Amedeo,, Foster, Ian,, Corbett, Kevin D.,, Fan, Qing R, Rapoport, Tom, Tjon, Emily C.,, Otwinowski, Zbyszek,, Blacklow, Stephen C., Raman, C. S., Christopher Fromme, J., Chazin, Walter J.,, McLellan, Jason S.,, Garcia, K. Christopher, Rapoport, Tom A., Baxter, Richard H.,, Fraser, James S.,, Nam, Yunsun, Tolia, Niraj H, Keenan, Robert J., Barbosa Pereira, Pedro Jose,, Harrison, Stephen C., Petosa, Carlo, Tao, Yizhi J., Barbosa Pereira, Pedro Jose, Gaudet, Rachelle, Withrow, James, Gong, Peng,, Modis, Yorgo,, Shamoo, Yousif,, Tsodikov, Oleg V, Westover, Kenneth D., Rapoport, Tom A.,, Eichman, Brandt F., Gaudet, Rachelle,, Ferré-D'Amaré, Adrian R, Bonvin, Alexandre MJJ, Pai, Emil F.,, Cosgrove, Michael S.,, Sliz, Piotr, Rajashankar, Kanagalaghatta,, Chang, Chung I., Pai, Emil F., Sondermann, Holger, Maia, Filipe R N C, Ransey, Elizabeth,, Kruse, Andrew C.,, Drennan, Catherine L, Lei, Ming,, Brett, Tom J, Buschiazzo, Alejandro,, Cosgrove, Michael S., Dhe-Paganon, Sirano, Borek, Dominika,, Harrison, Stephen, Key, Jason,, Raman, C.S., Rosen, Michael K.,, Keenan, Robert J.,, NMR Spectroscopy, Fan, Qing R., Wu, Hao,, Heldwein, Ekaterina E.,, Tolia, Niraj H., Socias, Stephanie, Chazin, Walter J, Sondermann, Holger,, Westover, Kenneth D, Sliz, Piotr,, Cosgrove, Michael S, Bonvin, Alexandre M. J. J.,, Shamoo, Yousif, Raman, CS, Di Cera, Enrico,, Pereira, Pedro José Barbosa, Schlessinger, Joseph, Fromme, J. Christopher,, Eck, Michael J., Jia, Zongchao, Maia, Filipe R. N C., Tsodikov, Oleg V.,, Eichman, Brandt F, Tolia, Niraj H.,, Bonvin, Alexandre M J J, Boggon, Titus J, McLellan, Jason S., Brett, Tom J., Schwartz, Thomas, Garcia, K. Christopher,, Rosen, Michael K., Buschiazzo, A, Fraser JS, Chang CI, Schwartz TU, Fraser, J, Emil F. Pai, Cosgrove MS, Michael K. Rosen, Raman, C, Yizhi J. Tao, Antonina Roll-Mecak, Chazin WJ, Alejandro Buschiazzo, James S. Fraser, Tom J. Brett, Ian Foster, Borek, D, Eck MJ, Rachelle Gaudet, Rapoport TA, Gabby Rudenko, Heldwein, E, Tjon, E, Nam, Y, Hao Wu, Tao YJ, Boggon TJ, Modis Y, Emily C. Tjon, David Neau, Meyer, Peter A. (author), Pedro José Barbosa Pereira, Crosson S, Kvansaku, Marc, et al,, Maia, F, Withrow J, Chang, C, Adrian R. Ferré-D'Amaré, Tolia NH, Filipe R. N C. Maia, Sondermann, H, Carlo Petosa, Withrow, J, Holger Sondermann, Crosas, M, Sliz P, Sirano Dhe-Paganon, Raman CS, Blacklow, S, Cosgrove, M, Meyer PA, Neau, David (author), Yunsun Nam, Kvansakul M, Heldwein EE, Kruse, A, Stephen C. Blacklow, Tjon, Emily C. (author), Botka, C, Rajashankar, K, Botka, Chris (author), Harrison, S, Westover KD, Anderson KS, Neau, D, Socias, Stephanie (author), Qing R. Fan, Westover, K, Buschiazzo, Alejandro (author), Tolia, N, Crosson, S, Dhe-Paganon S, James Withrow, Elizabeth Ransey, Borek D, Kirchhausen, T, Otwinowski Z, Ming Lei, Wu, H, Anderson, K, Fan, Q, Modis, Y, Botka C, Caflisch A, Kanagalaghatta Rajashankar, Meyer, P, Ferré-D'Amaré, A, Gaudet R, Eck, M, Enrico Di Cera, Bonvin AM, Shamoo Y, Ransey E, Dhe-Paganon, S, Tamir Gonen, Dominika Borek, Michael S. Cosgrove, Richard H. Baxter, Sliz, Piotr (author), Ferré-D'Amaré, Adrian R., Blacklow SC, Piotr Sliz, Joseph Schlessinger, Kay Diederichs, Alexandre M. J. J. Bonvin, Lei, M, Gaudet, R, Kruse AC, Rudenko G, Yorgo Modis, Eichman, B, Niraj H. Tolia, Stephen C. Harrison, Mercè Crosas, Tao, Y, Lei M, Corbett KD, Karen S. Anderson, Baxter RH, Zongchao Jia, Diederichs K, Sondermann H, Corbett, K, Jason Key, Socias S, Ransey, Elizabeth (author), Robert J. Keenan, Fan QR, Key, Jason (author), Marc Kvansakul, Yousif Shamoo, Kirchhausen T, Ferré-D'Amaré AR, Tsodikov OV, Rapoport, T, Bonvin, A, Keenan RJ, Brett TJ, Foster, I, Tom Kirchhausen, Andrew C. Kruse, Nam Y, Roll-Mecak, A, Kvansakul, M, Peng Gong, Jia Z, Diederichs, K, Ferre-D’Amare, Adrian R, Brandt F. Eichman, Key J, C. S. Raman, Tom A. Rapoport, Tjon EC, Drennan, C, Maia FR, Garcia KC, Catherine L. Drennan, Ekaterina E. Heldwein, Michael J. Eck, Eichman BF, Buschiazzo A, Petosa C, Chris Botka, Sliz, P, Pai EF, Titus J. Boggon, Kenneth D. Westover, Baxter, R, Schwartz, T, Pereira PJ, Ransey, E, J. Christopher Fromme, K. Christopher Garcia, Crosas M, Key, J, Neau D, Gong, P, Jia, Z, Roll-Mecak A, Peter A. Meyer, Gonen T, Oleg V. Tsodikov, Petosa, C, Rudenko, G, Amedeo Caflisch, Stephanie Socias, Rosen MK, Brett, T, Wu H, McLellan, J, Foster I, Kevin D. Corbett, Di Cera E, Pereira, PJ, McLellan JS, Schlessinger, J, Chazin, W, Sean Crosson, Keenan, R, Di Cera, E, Garcia, K, Gong P, Fromme JC, Fromme, J, Jason S. McLellan, Boggon, T, Gonen, T, Chung-I Chang, Withrow, James (author), Harrison SC, Pai, E, Thomas U. Schwartz, Caflisch, A, Drennan CL, Walter J. Chazin, Socias, S, Lei, Ming (author), Schlessinger J, Zbyszek Otwinowski, Otwinowski, Z, Rosen, M, Shamoo, Y, Rajashankar K, Tsodikov, O, Crosas, Merce, Ferre-D'Amare, Adrian R. +417 morecore +3 more sourcesLigand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada +5 morewiley +1 more sourceIntroduction to Experimental Biology
, 2001 7.02 and 7.021 require simultaneous registration. Application of experimental techniques in biochemistry, microbiology, and cell biology. Emphasizes integrating factual knowledge with understanding the design of experiments and data analysis to prepare ...Rich, Alexander, Kruzel, Deborah, Schneider, Katherine Bacon, Amon, Angelika, Chess, Andrew, Pardue, Mary Lou +5 morecore
