Results 171 to 180 of about 106,849 (287)

Effects of the signaling molecule cyclic-di-GMP on cyanobacterial circadian rhythm in <i>Synechococcus elongatus</i> PCC 7942. [PDF]

J Bacteriol
Yamaguchi CC, Kanaly RA, Nishizaki E, Yamashita K, Takatsuki K, Furuike Y, Fang M, Akiyama S, Aoki S, Tsukamoto M, Nakahira Y, Golden SS, Kutsuna S.   +12 more
europepmc   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Translational Pharmacokinetic-Pharmacodynamic Modeling and Efficacious Human Dose Prediction of DNDI-6148 for the Treatment of Cutaneous Leishmaniasis. [PDF]

Clin Transl Sci
Henninger RH, Schouten WM, Arana B, Gillon JY, Mowbray CE, Kratz JM, Van Bocxlaer K, Dorlo TPC.   +7 more
europepmc   +1 more source

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

BMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai, Rui Zhang, Haiyin Yang, Jiyue Xing, Tianyuan Hu, Mengxi Zhu, Rui Li, Xiaoli Chen, Beibei Zhao, Yang Lan, Stefan Barth, Yuanyu Huang, Li Zhang, Mengjie Zhang, Huining He   +14 more
wiley   +1 more source

Bioluminescent Probes for Multiplexed RNA Imaging. [PDF]

J Am Chem Soc
Fuller EB, Cole KH, Halbers LP, Chan CET, Ng KK, Scipioni L, Gohlke C, Digman MA, Steward O, Prescher JA, Lupták A.   +10 more
europepmc   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Novel Antiplasmodial Natural Products Identified Through a Modified Bioluminescence-Based Rate-of-Kill Assay. [PDF]

Biomedicines
Mobley R, Nasser SA, Bartholomew B, Nash R, Horrocks P, Price H.   +5 more
europepmc   +1 more source

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Development of a Glymphatic Pathway-based Rat Model for Cancer Metastasis from Brain to Lung. [PDF]

In Vivo
Sreejith A, Xiao H, Howson I, Bocchetta M, Aryal M.   +4 more
europepmc   +1 more source

Fear of grazing rivals the toxin‐inducing effects of nutrients in two marine harmful algae – a meta‐analysis

Biological Reviews, EarlyView.
ABSTRACT One of the major subfields of chemical ecology is the study of toxins and how they mediate interactions between organisms. Toxins produced by harmful algae (phycotoxins) impact a wide variety of organisms connected to the marine food web. Significant research efforts have thus aimed to identify the ecological and evolutionary drivers behind ...
Milad Pourdanandeh, Erik Selander
wiley   +1 more source