Results 191 to 200 of about 79,673 (289)

A dual-wavelength blue laser platform for integrated diagnosis and therapy in glioblastoma: preclinical evidence. [PDF]

Lasers Med Sci
Wang Z, Tao R, Jiang D, Guo Y, Xi K, He D.   +5 more
europepmc   +1 more source

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer

Advanced Science, EarlyView.
Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Meng Qian, Tongguan Tian, Zhenxiang Wang, Huihui Sun, Ming Zong, Ying Chen, Jie Xiong, Ye Chen, Zhiqian Hu, Tianming Li, Yanping Xu, Shuchang Xu   +11 more
wiley   +1 more source

Local delivery of interferon restores antigen presentation and sensitizes medulloblastoma to T cell killing. [PDF]

Proc Natl Acad Sci U S A
Eisemann T, Chambers KR, Beigi Masihi M, Tzaridis T, Gc S, Pister V, Youm I, Dutta A, Wenzel AT, Chin K, Xu Z, Pei Y, Pomeroy SL, Mesirov JP, Fraenkel E, Bagchi A, Chavez L, Wechsler-Reya RJ.   +17 more
europepmc   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Bioluminescence in the Edible Mushroom <i>Hypsizygus marmoreus</i> by Transformation with a Fungal Luciferase Gene. [PDF]

J Fungi (Basel)
Zhou X, Li Y, Wu Y, Chen R, Tang L, Zhou C, Wan J, Bao D, Yang R, Shang J.   +9 more
europepmc   +1 more source

Topological Quantum Biomaterials Enable Pyroptosis‐Senescence Coupling for Enhanced Colorectal Cancer Therapy

Advanced Science, EarlyView.
This work reports conceptually unprecedented topological quantum biomaterials derived from engineered Pd3Sn nanostrips for oncological applications. Their near‐Fermi‐level electronic architecture and superior interfacial charge transport facilitate ultrasound‐amplified redox reactions and efficient ROS generation.
Zilu Chen, Kun Mei, Yan Yang, Mengna Xu, Xinyue Dai, Renjun Gu, Fuqiong Zhou, Cheng Wang, Meiqi Chang, Yan Huang, Yu Chen   +10 more
wiley   +1 more source

Discovery of Pancreatic Lipase Inhibitory and Antimicrobial Constituents in Crataegi Folium by High-Performance Thin-Layer Chromatography-Bioautography-Mass Spectrometry. [PDF]

J Sep Sci
Zhu L, Ma AL, Zhang YL, Si ZH, Gu LH, Li LN, Yang L, Wang ZT.   +7 more
europepmc   +1 more source

Transfer RNA‐Derived Small RNA‐5’tiRNAGln Drives HNRNPC Phase Separation to Promote Breast Cancer Bone Metastasis by Regulating IGF1R

Advanced Science, EarlyView.
This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang, Dongsong Liu, Xiaozhi Fan, Jiale Fan, Xuesi liu, Yu Wang, Zixin Wang, Mo Cheng, Ping Zhou, Wangjun Yan   +9 more
wiley   +1 more source

Labeling and imaging of neurons with a genetically encoded autonomous bioluminescence system. [PDF]

Sci Rep
Brinker T, Günther A, Kiszka KA, Rhee JS, Gregor C.   +4 more
europepmc   +1 more source