Results 191 to 200 of about 106,849 (287)

An exhaustive cell-based screen coupled with an intracellular-induced lux-based reporter identified bioactive molecules that inhibit host cell infection by intracellular pathogens. [PDF]

Front Cell Infect Microbiol
Adani B, Plotnikov A, Lueken L, Shomer I, Shurrush K, Meyer N, Künnemann K, Kellermann M, Margulies D, Grassl GA, Hensel M, Barr HM, Gal-Mor O.   +12 more
europepmc   +1 more source

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro, Rosângela Mayer Gonçalves, Marcelle Gomes Pegurier, Isabelle Amorim, Alexandre Malta Rossi, Leandra Santos Baptista   +5 more
wiley   +1 more source

A practical guideline for in vivo bioluminescence imaging. [PDF]

Mol Cells
Lee H, Chae JS, Park HW.
europepmc   +1 more source

Molecular theranostics: principles, challenges and controversies

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley   +1 more source

Enhanced antitumoral activity of the academic CAR-T ARI0002h against normal and low BCMA-expressing myeloma cells after incorporating a transmembrane CD28 domain. [PDF]

J Immunother Cancer
Cardus O, Mañé Pujol J, de Daniel A, Moreno DF, Oliveira TGM, Battram AM, Salsench SV, Perez-Amill L, Llobregat H, Carpio Mármol J, Martin-Antonio B, Oliver-Caldes A, Munárriz D, Juan M, Urbano-Ispizua A, Rodríguez-Lobato LG, Fernández de Larrea C.   +16 more
europepmc   +1 more source

Method Based on Continuous Artificial Dry and Humid UV Treatments to Reduce the Luminescence Background in the Raman Spectra of Plastics

Journal of Raman Spectroscopy, EarlyView.
We propose an UV photobleaching pretreatment to reduce the strong luminescence in the Raman spectra of plastic samples. Our protocol proves its efficiency whatever the luminescence origin (from the pigments or from a surface biofilm) but requires a careful optimization of the illumination conditions (UV wavelength, time, humidity) to reach the ...
L. Dewyspelaere, L. Belec, I. Martin, V. Lenoble, A. Ruediger, A. Merlen   +5 more
wiley   +1 more source

Skin androgens regulate Staphylococcus aureus pathogenicity via quorum sensing. [PDF]

Nat Microbiol
John MS, Chinnappan M, Sturges CI, Artami M, Bhattacharya M, Keogh RA, Kavanaugh JS, Jain S, Gedamu H, Komarovsky J, Velasquez M, Sharma T, McDonald JG, Horswill AR, Harris-Tryon TA.   +14 more
europepmc   +1 more source

RTA‐408 Enhances Radiosensitivity and Inhibited Tumor Progression via JNK Pathway in Glioblastoma

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis owing to its high invasiveness and resistance to therapy. RTA‐408, a synthetic triterpenoid and nuclear factor erythroid 2‐related factor 2 activator, exhibits anti‐inflammatory and anti‐cancer properties; however, its effects on GBM remain unclear. This study investigated the
Hung‐Pei Tsai, Hao Qin, Yoon Bin Chong, I‐Hsiang Chen, Shih‐Hsun Kuo, Tzu‐Ting Tseng, Ann‐Shung Lieu   +6 more
wiley   +1 more source

Autophagy Plays a Suppressive Role in Bladder Tumor Formation in an Orthotopic Mouse Model and Bladder Cancer Patient Specimens

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy activity.
Wan‐Ting Kuo, Chin‐Chen Pan, Yi‐Wen Liu, Nan‐Haw Chow, Hong‐Lin Cheng, Shan‐Ying Wu, Sheng‐Hui Lan, Chih‐Peng Chang, Hsiao‐Sheng Liu   +8 more
wiley   +1 more source

KLS-3021, a multifunctional oncolytic virus, demonstrates potent early-intervention efficacy in preclinical models of prostate-confined and locally advanced prostate cancer. [PDF]

Front Oncol
Seo J, Park K, Lee S, Kang H, Kim J, Lee E, Shin J, Hong SO, Kim S, Kim SJ.   +9 more
europepmc   +1 more source