Results 221 to 230 of about 73,680 (292)

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro, Rosângela Mayer Gonçalves, Marcelle Gomes Pegurier, Isabelle Amorim, Alexandre Malta Rossi, Leandra Santos Baptista   +5 more
wiley   +1 more source

Intraperitoneal administration of NK-92 improves survival in xenografts of early and established ovarian cancer models. [PDF]

PLoS One
Marcus P, Warrington J, Zhang M, Ankathatti-Munegowda M, Wang XH, Rashedi I, Keating A.   +6 more
europepmc   +1 more source

Miniaturized Droplet‐Based Adaptation of the Ames Test for High‐Throughput Mutagenicity Assessment

Journal of Applied Toxicology, EarlyView.
ABSTRACT This work presents the first demonstration of a tube‐based droplet microfluidic implementation of the Ames test, bridging single‐droplet resolution with regulatory genotoxicity testing. The Ames test is a cornerstone assay for detecting mutagenicity, but conventional plate‐ and well‐based formats suffer from high reagent consumption, low ...
Jialan Cao, Bayan Nasr, J. Michael Köhler, Sebastian Buchinger   +3 more
wiley   +1 more source

Targeting IL-7Rα with PNU-159682 antibody-drug conjugates in acute lymphoblastic leukemia: translational implications. [PDF]

MAbs
Yang S, Anzai T, Tsumura R, Fuchigami H, Hamada M, Yuda J, Ikuta K, Yasunaga M.   +7 more
europepmc   +1 more source

Molecular theranostics: principles, challenges and controversies

Journal of Medical Radiation Sciences, Volume 72, Issue 1, Page 156-164, March 2025.
Molecular theranostics offers a powerful tool to drive precision medicine in nuclear oncology. While theranostics is not a new principle in nuclear medicine, recent advances in instrumentation and radiopharmacy have driven a reinvigoration and a broader suite of applications.
Geoffrey Currie
wiley   +1 more source

Method Based on Continuous Artificial Dry and Humid UV Treatments to Reduce the Luminescence Background in the Raman Spectra of Plastics

Journal of Raman Spectroscopy, EarlyView.
We propose an UV photobleaching pretreatment to reduce the strong luminescence in the Raman spectra of plastic samples. Our protocol proves its efficiency whatever the luminescence origin (from the pigments or from a surface biofilm) but requires a careful optimization of the illumination conditions (UV wavelength, time, humidity) to reach the ...
L. Dewyspelaere, L. Belec, I. Martin, V. Lenoble, A. Ruediger, A. Merlen   +5 more
wiley   +1 more source

Effects of the signaling molecule cyclic-di-GMP on cyanobacterial circadian rhythm in <i>Synechococcus elongatus</i> PCC 7942. [PDF]

J Bacteriol
Yamaguchi CC, Kanaly RA, Nishizaki E, Yamashita K, Takatsuki K, Furuike Y, Fang M, Akiyama S, Aoki S, Tsukamoto M, Nakahira Y, Golden SS, Kutsuna S.   +12 more
europepmc   +1 more source

Autophagy Plays a Suppressive Role in Bladder Tumor Formation in an Orthotopic Mouse Model and Bladder Cancer Patient Specimens

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Autophagy plays either a suppressing or promoting role during tumor development. Clarifying the role of autophagy in bladder tumorigenesis both in vitro and in vivo is crucial for developing novel therapeutic strategies through manipulating autophagy activity.
Wan‐Ting Kuo, Chin‐Chen Pan, Yi‐Wen Liu, Nan‐Haw Chow, Hong‐Lin Cheng, Shan‐Ying Wu, Sheng‐Hui Lan, Chih‐Peng Chang, Hsiao‐Sheng Liu   +8 more
wiley   +1 more source

Novel Antiplasmodial Natural Products Identified Through a Modified Bioluminescence-Based Rate-of-Kill Assay. [PDF]

Biomedicines
Mobley R, Nasser SA, Bartholomew B, Nash R, Horrocks P, Price H.   +5 more
europepmc   +1 more source

METTL14 Ameliorates Mitochondrial Dysfunction and Autophagy in Lens Epithelial Cells of Diabetic Cataracts via m6A Modification of RPL3

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Diabetic cataracts are a leading cause of blindness, with lens epithelial cells (LECs) exhibiting mitochondrial dysfunction and autophagy inhibition under high glucose (HG) conditions. Methyltransferase‐like 14 (METTL14), an RNA methyltransferase, regulates N6‐methyladenosine (m6A) RNA modification; however, its role in modulating ...
Rui Li, Xue Wang, Wei Du, Qian Li, Hong‐Ping Cui   +4 more
wiley   +1 more source