Results 271 to 280 of about 113,231 (318)

CaBLAM: a high-contrast bioluminescent Ca²⁺ indicator derived from an engineered Oplophorus gracilirostris luciferase. [PDF]

Nat Methods
Lambert GG, Crespo EL, Murphy J, Turner KL, Gershowitz E, Cunningham M, Boassa D, Luong S, Celinskis D, Allen JJ, Venn S, Zhu Y, Karadas M, Chen J, Marisca R, Gelnaw H, Nguyen DK, Hu J, Sprecher BN, Tree MO, Orcutt R, Heydari D, Bell AB, Torreblanca-Zanca A, Hakimi A, Czopka T, Shoham S, Nagel KI, Schoppik D, Andrade A, Lipscombe D, Moore CI, Hochgeschwender U, Shaner NC.   +33 more
europepmc   +1 more source

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, EarlyView.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

Engineered Peptide Scrambling for Enhanced Drug Delivery to Resistant Breast Cancer Cells via Small Extracellular Vesicles. [PDF]

ACS Appl Bio Mater
Babel A, Yuan J, A Saleh N, Al-Hilfi A, Kilangodi S, Sun J, Asgedom L, Withrow A, Gilad AA, Kanada M.   +9 more
europepmc   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Modification of H1N1 Influenza Luciferase Reporter Viruses Using StopGo Translation and/or Mouse-Adapted Mutations. [PDF]

Viruses
Chen PL, Yang G, Ojha C, Banoth B, Russell CJ.   +4 more
europepmc   +1 more source

Precision mRNA Delivery via Ultrasound‐Controlled Release Perfluorocarbon Emulsions: An Innovative Ultrasound Theranostic Strategy with 19F MRI Feasibility

Small, EarlyView.
A key challenge in advancing messenger RNA (mRNA) therapeutics in cardiovascular diseases lies in achieving controlled release at the precise site within the vasculature. This study presents the development of perfluorocarbon nanodroplets with exceptional theranostic potential, enabling real‐time tracking through ultrasound and fluorine‐19 (19F ...
Haikun Liu, Mark Louis P. Vidallon, Yuyang Song, Aidan P. G. Walsh, Henry Gordon, Shulei Ren, Pengkai Shi, Bangyan Xu, Mitchell J. Moon, Sylvain Trépout, Rico F. Tabor, Alexis I. Bishop, Ulrich Flögel, Karlheinz Peter, Xiaowei Wang   +14 more
wiley   +1 more source

Effect of EphA2 Silencing on Inhibiting the Progression of Renal Cell Carcinoma in an Orthotopic Mouse Model. [PDF]

Cells
Lee T, Lee HS, Yoo S, Bae H, Cho MC, Lee J, Jeong H.   +6 more
europepmc   +1 more source

An Integrated Method to Evaluate the Treatment Efficacy and Immunogenicity of B‐Cell Acute Lymphoblastic Leukemia Therapeutic Enzyme Formulations

Small Methods, EarlyView.
This work presents an integrated set of methods to evaluate the efficacy of asparaginase formulations against B‐cell Acute Lymphoblastic Leukemia (ALL) in mice, including the establishment of an ALL murine model, an amino acid depletion study using high‐performance liquid chromatography (HPLC), and comprehensive assessment of antibody production ...
Julien Santelli, Annie Y. Heble, Connor Endsley, Adam Woodward, Nazia Hafeez, Naomi Winick, Jacques Lux   +6 more
wiley   +1 more source

Global transcriptomics and targeted metabolite analysis reveal the involvement of the AcrAB efflux pump in physiological functions by exporting signaling molecules in <i>Photorhabdus laumondii</i>. [PDF]

Microbiol Spectr
Hadchity L, Lanois-Nouri A, Chouchou A, Roche D, Houard J, Claveyroles N, Dauvé A, Imbert J, Gualtieri M, Givaudan A, Carré-Mlouka A, Abi Khattar Z.   +11 more
europepmc   +1 more source

Exploring the impact of microbial dysbiosis on ovarian cancer and the therapeutic potential of probiotics

VIEW, EarlyView.
Ovarian cancer has been linked to the microbiome as a potential environmental contributor, but how this association relates to tumor progression remains unclear. By comparing tumor and nontumor tissues, we identified a severity‐associated microbial and metabolic signature and showed that probiotics can partially restore immune balance and slow tumor ...
Chanyuan Li, Nalan Tu, Xin Ning, Yunyan Cong, Fei Wu, Xiuli Zhang, Runrong Li, Yue Xu, Binqiao Wang, Liqin Jin, Yuanming Shen, Jihong Liu   +11 more
wiley   +1 more source