Results 201 to 210 of about 64,944 (323)

Highly Sensitive Bioluminescence Imaging Models for Chagas Disease Drug Discovery [PDF]

, 2017
John M. Kelly, Amanda Fortes Francisco, Shiromani Jayawardhana, Martin C. Taylor, Michael D. Lewis   +4 more
openalex   +1 more source

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

In vivo bioluminescence imaging of granzyme B activity in tumor response to cancer immunotherapy. [PDF]

Cell Chem Biol, 2022
Chen M, Zhou K, Dai SY, Tadepalli S, Balakrishnan PB, Xie J, Rami FEI, Dai T, Cui L, Idoyaga J, Rao J.   +10 more
europepmc   +1 more source

A Simplified Three‐Tailed N‐Alkyl Phosphoramidate Lipid Platform Enables Inguinal Adipose‐Accumulated mRNA Delivery for Anti‐Obesity Therapy

Advanced Science, EarlyView.
This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma, Yunxuan Liu, Huijuan Zhang, Yian Fang, Yizhe Xue, Junsheng Xue, Ziqiong Jiang, Tianyan Zhou, Yanyun Hao, Fei Xie, Lei Miao   +10 more
wiley   +1 more source

Fluorescent Protein Chromophore-Based Luciferins for Bioluminescence Imaging. [PDF]

Chem Biomed Imaging
Mangubat-Medina AE, Torrey ZR, Townsend KM, Kolbaba-Kartchner B, Mills JH, Prescher JA.   +5 more
europepmc   +1 more source

In vivo bioluminescence imaging of labile iron in xenograft models and liver using FeAL-1, an iron-activatable form of D-luciferin. [PDF]

Cell Chem Biol, 2023
Gonciarz RL, Jiang H, Tram L, Hugelshofer CL, Ekpenyong O, Knemeyer I, Aron AT, Chang CJ, Flygare JA, Collisson EA, Renslo AR.   +10 more
europepmc   +1 more source

Quantitative comparison of click beetle and firefly luciferases for in vivo bioluminescence imaging [PDF]

, 2007
Tewfik Miloud, Carmen Henrich, Günter J. Hämmerling   +2 more
openalex   +1 more source

Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

Advanced Science, EarlyView.
This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao   +17 more
wiley   +1 more source

Immune Response to Bioluminescence Imaging Reporters in Murine Tumor Models. [PDF]

Mol Imaging Biol
Basnet A, Thomas DD, Landreth KM, Damron FH, Liu TW.   +4 more
europepmc   +1 more source

S-Series Coelenterazine-Driven Combinatorial Bioluminescence Imaging Systems for Mammalian Cells. [PDF]

Int J Mol Sci, 2023
Kamiya G, Kitada N, Furuta T, Hirano T, Maki SA, Kim SB.   +5 more
europepmc   +1 more source