Results 101 to 110 of about 2,411,306 (333)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Basal-like breast cancer: molecular profiles, clinical features and survival outcomes

BMC Medical Genomics, 2017
Background Basal-like constitutes an important molecular subtype of breast cancer characterised by an aggressive behaviour and a limited therapy response. The outcome of patients within this subtype is, however, divergent.
Heloisa H. Milioli, Inna Tishchenko, Carlos Riveros, Regina Berretta, Pablo Moscato   +4 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

IGFBP-5 as a biomarker of de-differentiation in hepatocytes [PDF]

, 2011
Describes IGFBP-5 as a biomarker of de-differentiation in hepatocytes presented at the 47th Congress of the European-Societies-of ...
Flint, David, Grant, Mary, Henderson, Catherine, Large, Emma   +3 more
core   +1 more source

The Parkinson's progression markers initiative (PPMI) – establishing a PD biomarker cohort

Annals of Clinical and Translational Neurology, 2018
The Parkinson's Progression Markers Initiative (PPMI) is an observational, international study designed to establish biomarker‐defined cohorts and identify clinical, imaging, genetic, and biospecimen Parkinson's disease (PD) progression markers to ...
K. Marek, S. Chowdhury, A. Siderowf, Shirley Lasch, C. Coffey, C. Caspell-Garcia, T. Simuni, D. Jennings, C. Tanner, J. Trojanowski, L. Shaw, J. Seibyl, N. Schuff, A. Singleton, K. Kieburtz, A. Toga, B. Mollenhauer, D. Galasko, L. Chahine, D. Weintraub, T. Foroud, D. Tosun-Turgut, K. Poston, V. Arnedo, M. Frasier, T. Sherer, S. Bressman, M. Merchant, W. Poewe, C. Kopil, A. Naito, R. Dorsey, C. Casaceli, N. Daegele, J. Albani, L. Uribe, Eric D. Foster, J. Long, N. Seedorff, K. Crawford, Danielle Smith, P. Casalin, G. Malferrari, C. Halter, L. Heathers, D. Russell, S. Factor, P. Hogarth, A. Amara, R. Hauser, J. Jankovic, M. Stern, Shu‐Ching Hu, Gretchen Todd, R. Saunders-Pullman, I. Richard, H. Saint‐Hilaire, K. Seppi, H. Shill, Hubert H. Fernandez, C. Trenkwalder, W. Oertel, D. Berg, Kathrin Brockman, I. Wurster, L. Rosenthal, Yen F. Tai, N. Pavese, P. Barone, S. Isaacson, A. Espay, D. Rowe, M. Brandabur, J. Tetrud, G. Liang, Á. Iranzo, E. Tolosa, K. Marder, Maria de Sanchez, L. Stefanis, M. Marti, J. Martínez, J. Corvol, O. Assly, Salima Brillman, Nir Giladi, Debra Smejdir, Julia Pelaggi, F. Kausar, L. Rees, Barbara Sommerfield, Madeline Cresswell, C. Blair, Karen Williams, Grace A. Zimmerman, S. Guthrie, Ashlee Rawlins, Leigh Donharl, C. Hunter, B. Tran, A. Darin, Heli A. Venkov, Cathi A Thomas, Raymond James, B. Heim, Paul Deritis, F. Sprenger, D. Raymond, D. Willeke, Zoran Obradov, J. Mule, Nancy Monahan, K. Gauss, D. Fontaine, D. Szpak, Arita McCoy, Becky Dunlop, Laura Payne, Susan Ainscough, L. Carvajal, Rebecca Silverstein, Kristy J. Espay, Madelaine B. Rañola, E. Rezola, H. Santana, M. Stamelou, Alicia Garrido, S. Carvalho, G. Kristiansen, Krista Specketer, Anat Mirlman, M. Facheris, H. Soares, A. Mintun, J. Cedarbaum, Peggy Taylor, L. Slieker, Brian McBride, Colin Watson, Etienne Montagut, Z. Sheikh, Baris Bingol, R. Forrat, P. Sardi, T. Fischer, Dirk Reith, J. Egebjerg, L. Larsen, N. Breysse, D. Meulien, B. Saba, V. Kiyasova, C. Min, Thomas McAvoy, R. Umek, P. Iredale, J. Edgerton, Demetrio Santi, C. Czech, F. Boess, J. Sevigny, T. Kremer, I. Grachev, K. Merchant, Andreja Avbersek, P. Muglia, Alexandra Stewart, R. Prashad, Johannes Taucher   +168 more
semanticscholar   +1 more source

Cysteine and homocysteine as biomarker of various diseases

Food Science & Nutrition, 2020
Cysteine and homocysteine (Hcy), both sulfur‐containing amino acids (AAs), produced from methionine another sulfur‐containing amino acid, which is converted to Hcy and further converted to cysteine.
Tahniat Rehman, M. A. Shabbir, M. Inam-ur-Raheem, Muhammad Faisal Manzoor, N. Ahmad, Zhi-Wei Liu, M. Ahmad, Azhari Siddeeg, Muhammad Abid, Rana Muhammad Aadil   +9 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

HE4 in the differential diagnosis of ovarian masses [PDF]

, 2015
Ovarian masses, a common finding among pre- and post-menopausal women, can be benign or malignant. Ovarian cancer is the leading cause of death from gynecologic malignancy among women living in industrialized countries.
ANASTASI, Emanuela, ANGELONI, Antonio, Flavia Longo, MANGANARO, Lucia, PORPORA, Maria Grazia, Teresa Granato   +5 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A High-Quality Melon Genome Assembly Provides Insights into Genetic Basis of Fruit Trait Improvement

iScience, 2019
Summary: Accurate reference genomes have become indispensable tools for characterization of genetic and functional variations. Here we generated a high-quality assembly of the melon Payzawat using a combination of short-read sequencing, single-molecule ...
Hong Zhang, Xuming Li, Haiyan Yu, Yongbing Zhang, Meihua Li, Haojie Wang, Dengming Wang, Huaisong Wang, Qiushi Fu, Min Liu, Changmian Ji, Liming Ma, Juan Tang, Song Li, Jianshun Miao, Hongkun Zheng, Hongping Yi   +16 more
doaj   +1 more source