Results 91 to 100 of about 1,040,935 (315)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Investigating neonatal health risk variables through cell-type specific methylome-wide association studies

Clinical Epigenetics
Adverse neonatal outcomes are a prevailing risk factor for both short- and long-term mortality and morbidity in infants. Given the importance of these outcomes, refining their assessment is paramount for improving prevention and care.
Thomas L. Campbell, Lin Y. Xie, Ralen H. Johnson, Christina M. Hultman, Edwin J. C. G. van den Oord, Karolina A. Aberg   +5 more
doaj   +1 more source

AIM-Harvard/foundation-cancer-image-biomarker: v1

<h2>What's Changed</h2> <ul> <li>Added autopublish workflow by @surajpaib in https://github.com/AIM-Harvard/foundation-cancer-image-biomarker/pull/281</li> <li>Update code for additions - rev1 by @surajpaib in https ...
Ibrahim Hadzic, Suraj Pai, actions-user
core   +1 more source

Pooling serum samples may lead to loss of potential biomarkers in SELDI-ToF MS proteomic profiling.

, 2008
BACKGROUND: High throughput proteomic technology offers promise for the detection of disease biomarkers and proteomic signature patterns but biomarker discovery studies can be limited by cost factors when large sample size numbers are required.
Dan Agranoff, S Tariq Sadiq, Agranoff Dan, Sadiq S Tariq, Agranoff, D, Sadiq, ST   +5 more
core   +1 more source

The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group [PDF]

, 2021
The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed ...
The International Immuno-Oncology Biomarker Working Group
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Detection of Alzheimer's disease at mild cognitive impairment and disease progression using autoantibodies as blood‐based biomarkers

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2016
Introduction There is an urgent need to identify biomarkers that can accurately detect and diagnose Alzheimer's disease (AD). Autoantibodies are abundant and ubiquitous in human sera and have been previously demonstrated as disease‐specific biomarkers ...
Cassandra A. DeMarshall, Eric P. Nagele, Abhirup Sarkar, Nimish K. Acharya, George Godsey, Eric L. Goldwaser, Mary Kosciuk, Umashanger Thayasivam, Min Han, Benjamin Belinka, Robert G. Nagele, Alzheimer's Disease Neuroimaging Initiative   +11 more
doaj   +1 more source

A High-Quality Melon Genome Assembly Provides Insights into Genetic Basis of Fruit Trait Improvement

iScience, 2019
Summary: Accurate reference genomes have become indispensable tools for characterization of genetic and functional variations. Here we generated a high-quality assembly of the melon Payzawat using a combination of short-read sequencing, single-molecule ...
Hong Zhang, Xuming Li, Haiyan Yu, Yongbing Zhang, Meihua Li, Haojie Wang, Dengming Wang, Huaisong Wang, Qiushi Fu, Min Liu, Changmian Ji, Liming Ma, Juan Tang, Song Li, Jianshun Miao, Hongkun Zheng, Hongping Yi   +16 more
doaj   +1 more source

AIM-Harvard/foundation-cancer-image-biomarker: v1.0

<h2>What's Changed</h2> <ul> <li>Added autopublish workflow by @surajpaib in https://github.com/AIM-Harvard/foundation-cancer-image-biomarker/pull/281</li> <li>Update code for additions - rev1 by @surajpaib in https ...
Ibrahim Hadzic, Suraj Pai, actions-user
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source