Results 71 to 80 of about 1,164,667 (298)

Monolayer culture alters EGFR inhibitor response through abrogation of microRNA-mediated feedback regulation

Scientific Reports
Ex vivo drug screening is a potentially powerful tool for the future of cancer care, but the accuracy of results is contingent on the culture model. Both monolayer (2D) and spheroid (3D) culture systems offer advantages, but given the differences in ...
Angela Florio, Sarah Johnson, Rebecca Salvatori, George Vasmatzis   +3 more
doaj   +1 more source

ctDNA and CTCs in Liquid Biopsy – Current Status and Where We Need to Progress

Computational and Structural Biotechnology Journal, 2018
We discuss the current status of liquid biopsy and its advantages and challenges with a focus on pre-analytical sample handling, technologies and workflows. The potential of circulating tumor cells and circulating tumor DNA is pointed out and an overview
Martin H.D. Neumann, Sebastian Bender, Thomas Krahn, Thomas Schlange   +3 more
doaj   +1 more source

Fine-grained cell-type specific association studies with human bulk brain data using a large single-nucleus RNA sequencing based reference panel

Scientific Reports, 2023
Brain disorders are leading causes of disability worldwide. Gene expression studies provide promising opportunities to better understand their etiology but it is critical that expression is studied on a cell-type level.
Edwin J. C. G. van den Oord, Karolina A. Aberg   +1 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

AIM-Harvard/foundation-cancer-image-biomarker: v1.0.0

<h2>What's Changed</h2> <ul> <li>Added autopublish workflow by @surajpaib in https://github.com/AIM-Harvard/foundation-cancer-image-biomarker/pull/281</li> <li>Update code for additions - rev1 by @surajpaib in https ...
Ibrahim Hadzic, Suraj Pai, actions-user
core   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Pooling serum samples may lead to loss of potential biomarkers in SELDI-ToF MS proteomic profiling. [PDF]

, 2008
BACKGROUND: High throughput proteomic technology offers promise for the detection of disease biomarkers and proteomic signature patterns but biomarker discovery studies can be limited by cost factors when large sample size numbers are required.
Dan Agranoff, S Tariq Sadiq, Agranoff Dan, Sadiq S Tariq, Agranoff, D, Sadiq, ST   +5 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Biomarker-Guided Versus Guideline-Based Treatment of Patients With Heart Failure: Results From BIOSTAT-CHF

, 2018
Background: Heart failure guidelines recommend up-titration of angiotensin-converting enzyme (ACE) inhibitor/angiotensin receptor blockers (ARBs), beta-blockers, and mineralocorticoid receptor antagonists (MRAs) to doses used in randomized clinical ...
M. Metra (6176873), S. D. Anker (7604402), A. A. Voors (7594622), D. J. van Veldhuisen (7594628), Leong L. Ng (7162769), Nilesh J. Samani (7579793), C. C. Lang (7735544), G. Filippatos (7750994), H. L. Hillege (7594619), F. Zannad (7750988), A. H. Zwinderman (3801265), P. van der Harst (7594607), J. M. Ter Maaten (7750991), K. Dickstein (7750997), B. Demissei (7750985), J. G. Cleland (7751000), W. Ouwerkerk (7750982), P. Ponikowski (7604393)   +17 more
core   +6 more sources

Basal-like breast cancer: molecular profiles, clinical features and survival outcomes

BMC Medical Genomics, 2017
Background Basal-like constitutes an important molecular subtype of breast cancer characterised by an aggressive behaviour and a limited therapy response. The outcome of patients within this subtype is, however, divergent.
Heloisa H. Milioli, Inna Tishchenko, Carlos Riveros, Regina Berretta, Pablo Moscato   +4 more
doaj   +1 more source