Results 131 to 140 of about 2,295,331 (380)

Imaging biomarker roadmap for cancer studies

Nature Reviews Clinical Oncology, 2016
Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction.

semanticscholar   +1 more source

MicroRNA 196a contributes to the aggressiveness of esophageal adenocarcinoma through the MYC/TERT/NFκB axis

Molecular Oncology, EarlyView.
mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo, Carlos M. Martínez‐Cáceres, Manuel Bernabé‐García, Vicente Munitiz, David Ruiz de Angulo, Pascual Parrilla, Ángeles Ortiz, Luisa F. Martínez de Haro, María L. Cayuela   +8 more
wiley   +1 more source

Investigating neonatal health risk variables through cell-type specific methylome-wide association studies

Clinical Epigenetics
Adverse neonatal outcomes are a prevailing risk factor for both short- and long-term mortality and morbidity in infants. Given the importance of these outcomes, refining their assessment is paramount for improving prevention and care.
Thomas L. Campbell, Lin Y. Xie, Ralen H. Johnson, Christina M. Hultman, Edwin J. C. G. van den Oord, Karolina A. Aberg   +5 more
doaj   +1 more source

Development of an in vitro model to study the role of disulfide bonds in the largest extracellular domain of the sodium-dependent phosphate transporter NaPi2b in OVCAR-8 ovarian carcinoma cells

Успехи молекулярной онкологии
Introduction. The sodium-dependent phosphate transporter NaPi2b is a promising target for targeted antitumor therapy. There is the largest extracellular domain (ECD) containing a cryptic MX35 epitope, against which therapeutic antibodies have been ...
V. S. Skripova, D. A. Firsova, A. V. Kilunov, L. F. Bulatova, M. A. Poputsky, R. G. Kiyamova   +5 more
doaj   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Detection of Alzheimer's disease at mild cognitive impairment and disease progression using autoantibodies as blood‐based biomarkers

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2016
Introduction There is an urgent need to identify biomarkers that can accurately detect and diagnose Alzheimer's disease (AD). Autoantibodies are abundant and ubiquitous in human sera and have been previously demonstrated as disease‐specific biomarkers ...
Cassandra A. DeMarshall, Eric P. Nagele, Abhirup Sarkar, Nimish K. Acharya, George Godsey, Eric L. Goldwaser, Mary Kosciuk, Umashanger Thayasivam, Min Han, Benjamin Belinka, Robert G. Nagele, Alzheimer's Disease Neuroimaging Initiative   +11 more
doaj   +1 more source

A High-Quality Melon Genome Assembly Provides Insights into Genetic Basis of Fruit Trait Improvement

iScience, 2019
Summary: Accurate reference genomes have become indispensable tools for characterization of genetic and functional variations. Here we generated a high-quality assembly of the melon Payzawat using a combination of short-read sequencing, single-molecule ...
Hong Zhang, Xuming Li, Haiyan Yu, Yongbing Zhang, Meihua Li, Haojie Wang, Dengming Wang, Huaisong Wang, Qiushi Fu, Min Liu, Changmian Ji, Liming Ma, Juan Tang, Song Li, Jianshun Miao, Hongkun Zheng, Hongping Yi   +16 more
doaj   +1 more source

Performance of PCA3 and TMPRSS2:ERG urinary biomarkers in prediction of biopsy outcome in the Canary Prostate Active Surveillance Study (PASS). [PDF]

, 2019
BackgroundFor men on active surveillance for prostate cancer, biomarkers may improve prediction of reclassification to higher grade or volume cancer.
Bianchi-Frias, Daniella, Brooks, James D, Brown, Marshall D, Carroll, Peter R, Cooperberg, Matthew R, Dash, Atreya, Fabrizio, Michael D, Faino, Anna V, Gleave, Martin E, Lin, Daniel W, Liss, Michael, Morgan, Todd M, Nelson, Peter S, Newcomb, Lisa F, Thompson, Ian M, Wagner, Andrew A, Zheng, Yingye   +16 more
core  

Asymptotic properties of the sequential empirical ROC, PPV and NPV curves under case-control sampling

, 2012
The receiver operating characteristic (ROC) curve, the positive predictive value (PPV) curve and the negative predictive value (NPV) curve are three measures of performance for a continuous diagnostic biomarker.
Feng, Ziding, Koopmeiners, Joseph S.
core   +1 more source

Revisiting biomarker discovery by plasma proteomics

Molecular Systems Biology, 2017
Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support treatment decisions.
Philipp E. Geyer, L. Holdt, D. Teupser, M. Mann   +3 more
semanticscholar   +1 more source