Results 11 to 20 of about 2,411,306 (333)
Anatomy of an extinction revealed by molecular fossils spanning OAE2
Scientific Reports, 2021 The Cenomanian–Turonian mass extinction (Oceanic Anoxic Event 2-OAE2) was a period of profound ecological change that is recorded in the sedimentary record in many locations around the globe.
R. M. Forkner +5 more
doaj +1 more source
Nature Communications, 2021 The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (CDX ...
Maximilian W. Schenk +18 more
doaj +1 more source
Metagenomic biomarker discovery and explanation
Genome Biology, 2011 This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation.
N. Segata +6 more
semanticscholar +1 more source
An epigenetic biomarker of aging for lifespan and healthspan
bioRxiv, 2018 Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using chronological age as a surrogate for biological age, we hypothesized that incorporation of ...
M. Levine +17 more
semanticscholar +1 more source
The Optimized Workflow for Sample Preparation in LC-MS/MS-Based Urine Proteomics
Methods and Protocols, 2019 The sample condition is an important factor in urine proteomics with stability and accuracy. However, a general protocol of urine protein preparation in mass spectrometry analysis has not yet been established.
Suguru Saito +8 more
doaj +1 more source
Identification of genetic variants related to metabolic syndrome by next-generation sequencing
Diabetology & Metabolic Syndrome, 2022 Background Metabolic syndrome (MetS) is a cluster of conditions associated with glucose intolerance, hypertension, abdominal obesity, dyslipidemia, and insulin resistance that increase the risk of cardiovascular diseases (CVD) and type 2 diabetes (T2D ...
Sanghoo Lee +8 more
doaj +1 more source
A Bayesian adaptive marker‐stratified design for molecularly targeted agents with customized hierarchical modeling [PDF]
, 2019 It is well known that the treatment effect of a molecularly targeted agent (MTA) may vary dramatically, depending on each patient's biomarker profile. Therefore, for a clinical trial evaluating MTA, it is more reasonable to evaluate its treatment effect ...
Cao, Sha +4 more
core +3 more sources
Clinical Proteomics, 2018 Advances in the field of targeted proteomics and mass spectrometry have significantly improved assay sensitivity and multiplexing capacity. The high-throughput nature of targeted proteomics experiments has increased the rate of data production, which ...
Shadi Toghi Eshghi +2 more
doaj +1 more source
How shall we use the proteomics toolbox for biomarker discovery? [PDF]
, 2007 Biomarker discovery for clinical purposes is one of the major areas in which proteomics is used. However, despite considerable effort, the successes have been relatively scarce.
Hochstrasser, Denis +2 more
core +5 more sources
Development of tumor mutation burden as an immunotherapy biomarker: utility for the oncology clinic
Annals of Oncology, 2018 Background Treatment with immune checkpoint blockade (ICB) with agents such as anti-programmed cell death protein 1 (PD-1), anti-programmed death-ligand 1 (PD-L1), and/or anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) can result in impressive ...
T. Chan +6 more
semanticscholar +1 more source