Results 11 to 20 of about 746,277 (164)
Identification of genetic variants related to metabolic syndrome by next-generation sequencing
Diabetology & Metabolic Syndrome, 2022 Background Metabolic syndrome (MetS) is a cluster of conditions associated with glucose intolerance, hypertension, abdominal obesity, dyslipidemia, and insulin resistance that increase the risk of cardiovascular diseases (CVD) and type 2 diabetes (T2D ...
Sanghoo Lee +8 more
doaj +1 more source
The Optimized Workflow for Sample Preparation in LC-MS/MS-Based Urine Proteomics
Methods and Protocols, 2019 The sample condition is an important factor in urine proteomics with stability and accuracy. However, a general protocol of urine protein preparation in mass spectrometry analysis has not yet been established.
Suguru Saito +8 more
doaj +1 more source
Disease Knowledge Transfer across Neurodegenerative Diseases [PDF]
, 2019 We introduce Disease Knowledge Transfer (DKT), a novel technique for transferring biomarker information between related neurodegenerative diseases. DKT infers robust multimodal biomarker trajectories in rare neurodegenerative diseases even when only ...
Alexander, Daniel C. +10 more
core +3 more sources
ERJ Open Research, 2021 Introduction COPD exacerbations are heterogeneous and can be triggered by bacterial, viral, or noninfectious insults. Exacerbations are also heterogeneous in neutrophilic or eosinophilic inflammatory responses.
Arindam Chakrabarti +13 more
doaj +1 more source
Clinical and Translational Medicine, 2014 Background Clinically useful biomarkers for patient stratification and monitoring of disease progression and drug response are in big demand in drug development and for addressing potential safety concerns.
Martin Letzkus +14 more
doaj +1 more source
A targeted solution for estimating the cell-type composition of bulk samples
BMC Bioinformatics, 2021 Background To avoid false-positive findings and detect cell-type specific associations in methylation and transcription investigations with bulk samples, it is critical to know the proportions of the major cell-types.
Edwin J. C. G. van den Oord +4 more
doaj +1 more source
Proteomes, 2018 Diabetic mellitus (DM) is a disease that affects glucose homeostasis and causes complications, such as diabetic nephropathy (DN). For early diagnosis of DN, microalbuminuria is currently one of the most frequently used biomarkers.
Yoshitoshi Hirao +8 more
doaj +1 more source
Biomarker reveals HIV's hidden reservoir. [PDF]
, 2014 Determining the total amount of HIV DNA in people undergoing antiretroviral therapy could accelerate the development of novel therapies and potential cures for HIV ...
Cockerham, Leslie R, Deeks, Steven G
core +2 more sources
Computational Models for Transplant Biomarker Discovery. [PDF]
, 2015 Translational medicine offers a rich promise for improved diagnostics and drug discovery for biomedical research in the field of transplantation, where continued unmet diagnostic and therapeutic needs persist.
Sarwal, Minnie M, Wang, Anyou
core +2 more sources
A Bayesian adaptive marker‐stratified design for molecularly targeted agents with customized hierarchical modeling [PDF]
, 2019 It is well known that the treatment effect of a molecularly targeted agent (MTA) may vary dramatically, depending on each patient's biomarker profile. Therefore, for a clinical trial evaluating MTA, it is more reasonable to evaluate its treatment effect ...
Cao, Sha +4 more
core +2 more sources