Results 31 to 40 of about 1,046,417 (216)

Biomarkers of aging

Science China Life Sciences, 2023
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitations remain poorly characterized.
Bao, Hainan, Cao, Jiani, Chen, Mengting, Chen, Min, Chen, Wei, Chen, Xiao, Chen, Yanhao, Chen, Yu, Chen, Yutian, Chen, Zhiyang, Chhetri, Jagadish K., Ding, Yingjie, Feng, Junlin, Guo, Jun, Guo, Mengmeng, He, Chuting, Jia, Yujuan, Jiang, Haiping, Jing, Ying, Li, Dingfeng, Li, Jiaming, Li, Jingyi, Liang, Qinhao, Liang, Rui, Liu, Feng, Liu, Xiaoqian, Liu, Zuojun, Luo, Oscar Junhong, Lv, Jianwei, Ma, Jingyi, Mao, Kehang, Nie, Jiawei, Qiao, Xinhua, Sun, Xinpei, Tang, Xiaoqiang, Wang, Jianfang, Wang, Qiaoran, Wang, Siyuan, Wang, Xuan, Wang, Yaning, Wang, Yuhan, Wu, Rimo, Xia, Kai, Xiao, Fu-Hui, Xu, Lingyan, Xu, Yingying, Yan, Haoteng, Yang, Liang, Yang, Ruici, Yang, Yuanxin, Ying, Yilin, Zhang, Le, Zhang, Weiwei, Zhang, Wenwan, Zhang, Xing, Zhang, Zhuo, Zhou, Min, Zhou, Rui, Zhu, Qingchen, Zhu, Zhengmao, Cao, Feng, Cao, Zhongwei, Chan, Piu, Chen, Chang, Chen, Guobing, Chen, Hou-Zao, Chen, Jun, Ci, Weimin, Ding, Bi-Sen, Ding, Qiurong, Gao, Feng, Han, Jing-Dong J., Huang, Kai, Ju, Zhenyu, Kong, Qing-Peng, Li, Ji, Li, Jian, Li, Xin, Liu, Baohua, Liu, Feng, Liu, Lin, Liu, Qiang, Liu, Qiang, Liu, Xingguo, Liu, Yong, Luo, Xianghang, Ma, Shuai, Ma, Xinran, Mao, Zhiyong, Nie, Jing, Peng, Yaojin, Qu, Jing, Ren, Jie, Ren, Ruibao, Song, Moshi, Songyang, Zhou, Sun, Yi Eve, Sun, Yu, Tian, Mei, Wang, Shusen, Wang, Si, Wang, Xia, Wang, Xiaoning, Wang, Yan-Jiang, Wang, Yunfang, Wong, Catherine C. L., Xiang, Andy Peng, Xiao, Yichuan, Xie, Zhengwei, Xu, Daichao, Ye, Jing, Yue, Rui, Zhang, Cuntai, Zhang, Hongbo, Zhang, Liang, Zhang, Weiqi, Zhang, Yong, Zhang, Yun-Wu, Zhang, Zhuohua, Zhao, Tongbiao, Zhao, Yuzheng, Zhu, Dahai, Zou, Weiguo, Pei, Gang, Liu, Guang-Hui   +124 more
openaire   +2 more sources

Pathophysiologic Insights from Biomarker Studies in Neurological Disorders

, 2020
Neuroimmunological and neurodegenerative disorders are major healthcare issues associated with high individual and socioeconomic burden. For many neurological disorders an early diagnosis is key for efficient management and therapy.

core   +1 more source

Toward a Topology-Based Therapeutic Design of Membrane Proteins: Validation of NaPi2b Topology in Live Ovarian Cancer Cells

Frontiers in Molecular Biosciences, 2022
NaPi2b is a sodium-dependent phosphate transporter that belongs to the SLC34 family of transporters which is mainly responsible for phosphate homeostasis in humans.
Leisan Bulatova, Daria Savenkova, Alsina Nurgalieva, Daria Reshetnikova, Arina Timonina, Vera Skripova, Mikhail Bogdanov, Mikhail Bogdanov, Ramziya Kiyamova   +8 more
doaj   +1 more source

Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland? [PDF]

, 2012
Background <p> The search for biomarkers of aging (BoAs) has been largely unsuccessful to-date and there is widespread skepticism about the prospects of finding any that satisfy the criteria developed by the American Federation of Aging Research ...
Batty, G.D., Robertson, T., Shiels, PG, Shiels Paul G., Benzeval, Michaela, Michaela Benzeval, McGlynn, Liane, G David Batty, Ian J Deary, McIntyre, A., McIntyre, A, Michael J Green, Benzeval, M, Tony Robertson, Der, G, Alan McIntyre, Paul G Shiels, McIntyre Alan, Robertson, Tony, Shiels, Paul G, Green, Michael J, Green, M.J., McGlynn Liane, McIntyre, Alan, Deary, Ian J, Der, Geoff, Robertson, T, Geoff Der, Green, MJ, McGlynn, L., McGlynn, L, Green Michael J., Deary, Ian, Deary Ian J., Der, G., Liane McGlynn, Batty G. David, McGlynn, Liane M, Robertson Tony, Batty, GD, Benzeval, M., Shiels, P.G., Batty, G David, Benzeval Michaela, Deary, IJ, Deary, I.J., Der Geoff   +46 more
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Atezolizumab plus bevacizumab combination enables an unresectable hepatocellular carcinoma resectable and links immune exclusion and tumor dedifferentiation to acquired resistance

Experimental Hematology & Oncology, 2021
We reported a patient with unresectable hepatocellular carcinoma (HCC) who initially received 15 cycles of atezolizumab plus bevacizumab combination and had best tumor response of partial response, but later experienced disease progression.
Yulei Wang, Li-Chun Lu, Yinghui Guan, Ming-Chih Ho, Shan Lu, Jessica Spahn, Chih-Hung Hsu   +6 more
doaj   +1 more source

Glucosylsphingosine Is a Highly Sensitive and Specific Biomarker for Primary Diagnostic and Follow-Up Monitoring in Gaucher Disease in a Non-Jewish, Caucasian Cohort of Gaucher Disease Patients

, 2013
Gaucher disease (GD) is the most common lysosomal storage disorder (LSD). Based on a deficient β-glucocerebrosidase it leads to an accumulation of glucosylceramide. Standard diagnostic procedures include measurement of enzyme activity, genetic testing as
Rolfs, A, Hermann Mascher, Boettcher, T, Anne-Katrin Giese (440558), Wittstock, M, Huebner, R, Roehle, A, Arndt Rolfs (140849), Zimran Ari, Deborah Elstein (487463), Mascher Hermann, Deborah Elstein, Ari Zimran, Röhle Anja, Wittstock Matthias, Arndt Rolfs, Grittner Ulrike, Tobias Böttcher (451245), Grittner, U, Jan Lukas, Rolfs Arndt, Jan Lukas (338014), Rayk Hübner (487464), Rayk Hübner, Uta Gölnitz, Ales Dudesek, Lukas Jan, Anja Röhle, Daniel Mascher (487462), Meyer, W, Tobias Böttcher, Giese, A-K, Mascher Daniel, Giese Anne-Katrin, Hermann Mascher (440562), Anne-Katrin Giese, Goelnitz, U, Daniel Mascher, Dudesek Ales, Ulrike Grittner, Uta Gölnitz (87824), Zimran, A, Matthias Wittstock (487467), Mascher, H, Elstein, D, Dudesek, A, Gölnitz Uta, Matthias Wittstock, Böttcher Tobias, Hübner Rayk, Ulrike Grittner (440560), Mascher, D, Ari Zimran (266246), Lukas, J, Wolfgang Meyer, Meyer Wolfgang, Wolfgang Meyer (440563), Elstein Deborah, Anja Röhle (487465), Ales Dudesek (487466)   +59 more
core   +1 more source

Analytical evaluation of circulating tumor DNA sequencing assays

Scientific Reports
In China, circulating tumor DNA analysis is widely used and numerous assays are available. Systematic evaluation to help users make informed selections is needed.
Wenjin Li, Xiayu Huang, Rajesh Patel, Erica Schleifman, Shijing Fu, David S. Shames, Jingyu Zhang   +6 more
doaj   +1 more source

Cell-free DNA methylome and fragmentome analysis for relapse monitoring of Ewing sarcoma

EMBO Molecular Medicine
Liquid biopsies and cell-free DNA (cfDNA) offer minimally invasive methods for the diagnosis and monitoring of Ewing Sarcoma (EwS). EwS have a low tumour mutational burden and their detection with plasma cfDNA is challenging.
Sophie A Richardson, Aram Safrastyan, Mina Karimpour, Gayatri Gulati, Patrick J B Harker, Alan Redfern, Simon P Pearce, Vsevolod J Makeev, Bernadette Brennan, Alexander T J Lee, Alexandra Clipson, Steven M Hill, Caroline Dive, Dominic G Rothwell, Martin G McCabe, Florent Mouliere   +15 more
doaj   +1 more source

Direct isolation and characterization of circulating exosomes from biological samples using magnetic nanowires

Journal of Nanobiotechnology, 2019
Background Tumor-derived exosomes are gaining attention as important factors that facilitate communication between neighboring cells and manipulate cellular processes associated with cancer development or progression.
Jiyun Lim, Mihye Choi, HyungJae Lee, Young-Ho Kim, Ji-Youn Han, Eun Sook Lee, Youngnam Cho   +6 more
doaj   +1 more source

Characterization of Cancer/Testis Antigens as Prognostic Markers of Ovarian Cancer

Diagnostics, 2023
The main goal of this study was to characterize cancer/testis antigens (CTAs) as potential molecular markers of ovarian cancer. First, we gathered and analyzed a significantly large dataset of 21 selected CTAs that are encoded by 32 genes; the dataset ...
Ramilia Vlasenkova, Daliya Konysheva, Alsina Nurgalieva, Ramziya Kiyamova   +3 more
doaj   +1 more source