Results 21 to 30 of about 1,725,920 (355)

Identification of genetic variants related to metabolic syndrome by next-generation sequencing

Diabetology & Metabolic Syndrome, 2022
Background Metabolic syndrome (MetS) is a cluster of conditions associated with glucose intolerance, hypertension, abdominal obesity, dyslipidemia, and insulin resistance that increase the risk of cardiovascular diseases (CVD) and type 2 diabetes (T2D ...
Sanghoo Lee, Seol-A Kim, Jeonghoon Hong, Yejin Kim, Gayeon Hong, SaeYun Baik, Kyeonghwan Choi, Mi-Kyeong Lee, Kyoung-Ryul Lee   +8 more
doaj   +1 more source

Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program [PDF]

, 2017
Biomarkers for Parkinson's disease (PD) diagnosis, prognostication and clinical trial cohort selection are an urgent need. While many promising markers have been discovered through the National Institute of Neurological Disorders and Stroke Parkinson's ...
Albin, Roger, Alcalay, Roy N., Babcock, Debra, Bowman, F. DuBois, Chen-Plotkin, Alice, David, Karen K., Dawson, Ted M., Dewey, Richard B., Jr., Foroud, Tatiana, German, Dwight, Gwinn, Katrina, Huang, Xuemei, Lungu, Codrin, Petyuk, Vlad, Potashkin, Judith A., Rosenthal, Liana S., Saunders-Pullman, Rachel, Scherzer, Clemens R., Sieber, Beth-Anne, St Hillaire-Clarke, Coryse, Sutherland, Margaret, Swanson-Fischer, Christine, Vaillancourt, David E., Walt, David R., West, Andrew B., Zhang, Jing   +25 more
core   +1 more source

Biomarkers of apoptosis [PDF]

British Journal of Cancer, 2008
Within the era of molecularly targeted anticancer agents, it has become increasingly important to provide proof of mechanism as early on as possible in the drug development cycle, especially in the clinic. Selective activation of apoptosis is often cited as one of the major goals of cancer chemotherapy.
Ward, T. H., Cummings, J., Dean, E., Greystoke, A., Hou, J. M., Backen, A., Ranson, M., Dive, C.   +7 more
openaire   +3 more sources

Gene expression profiling of immunomagnetically separated cells directly from stabilized whole blood for multicenter clinical trials

Clinical and Translational Medicine, 2014
Background Clinically useful biomarkers for patient stratification and monitoring of disease progression and drug response are in big demand in drug development and for addressing potential safety concerns.
Martin Letzkus, Evert Luesink, Sandrine Starck‐Schwertz, Marc Bigaud, Fareed Mirza, Nicole Hartmann, Bernhard Gerstmayer, Uwe Janssen, Andreas Scherer, Martin M Schumacher, Aurelie Verles, Alessandra Vitaliti, Nanguneri Nirmala, Keith J Johnson, Frank Staedtler   +14 more
doaj   +1 more source

Biomarker Jeopardy

Journal of the Advanced Practitioner in Oncology, 2022
In the popular Biomarker Jeopardy session, Sandra E. Kurtin, PhD, ANP-C, AOCN®, Alyssa Henglefelt, PharmD, BCOP, and Haleigh Mistry, MS, PA-C, paired biomarkers with tumor types for which their expression is most commonly used to determine targeted therapy, identified key assays used to measure common biomarkers, and discussed guidelines for biomarker ...
Kurtin, Sandra E., Henglefelt, Alyssa, Mistry, Haleigh   +2 more
openaire   +2 more sources

Stable Feature Selection for Biomarker Discovery [PDF]

, 2010
Feature selection techniques have been used as the workhorse in biomarker discovery applications for a long time. Surprisingly, the stability of feature selection with respect to sampling variations has long been under-considered.
He, Zengyou, Yu, Weichuan
core   +2 more sources

Proteome Profiling of Diabetic Mellitus Patient Urine for Discovery of Biomarkers by Comprehensive MS-Based Proteomics

Proteomes, 2018
Diabetic mellitus (DM) is a disease that affects glucose homeostasis and causes complications, such as diabetic nephropathy (DN). For early diagnosis of DN, microalbuminuria is currently one of the most frequently used biomarkers.
Yoshitoshi Hirao, Suguru Saito, Hidehiko Fujinaka, Shigeru Miyazaki, Bo Xu, Ali F. Quadery, Amr Elguoshy, Keiko Yamamoto, Tadashi Yamamoto   +8 more
doaj   +1 more source

Clinical applications of squamous cell carcinoma antigen-immunoglobulins M to monitor chronic hepatitis C [PDF]

, 2015
Hepatitis C virus (HCV) is the main cause of chronic liver disease and cirrhosis in Western countries. Over time, the majority of cirrhotic patients develop hepatocellular carcinoma (HCC), one of the most common fatal cancers worldwide - fourth for ...
Fassina, Giorgio, Gallotta, Andrea, MARTINI, ANDREA, PONTISSO, PATRIZIA   +3 more
core   +1 more source

A targeted solution for estimating the cell-type composition of bulk samples

BMC Bioinformatics, 2021
Background To avoid false-positive findings and detect cell-type specific associations in methylation and transcription investigations with bulk samples, it is critical to know the proportions of the major cell-types.
Edwin J. C. G. van den Oord, Lin Y. Xie, Charles J. Tran, Min Zhao, Karolina A. Aberg   +4 more
doaj   +1 more source

High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis

ERJ Open Research, 2021
Introduction COPD exacerbations are heterogeneous and can be triggered by bacterial, viral, or noninfectious insults. Exacerbations are also heterogeneous in neutrophilic or eosinophilic inflammatory responses.
Arindam Chakrabarti, Jordan S. Mar, David F. Choy, Yi Cao, Nisha Rathore, Xiaoying Yang, Gaik W. Tew, Olga Li, Prescott G. Woodruff, Christopher E. Brightling, Michele Grimbaldeston, Stephanie A. Christenson, Mona Bafadhel, Carrie M. Rosenberger   +13 more
doaj   +1 more source