Results 21 to 30 of about 1,166,102 (300)

High serum granulocyte-colony stimulating factor characterises neutrophilic COPD exacerbations associated with dysbiosis

ERJ Open Research, 2021
Introduction COPD exacerbations are heterogeneous and can be triggered by bacterial, viral, or noninfectious insults. Exacerbations are also heterogeneous in neutrophilic or eosinophilic inflammatory responses.
Arindam Chakrabarti, Jordan S. Mar, David F. Choy, Yi Cao, Nisha Rathore, Xiaoying Yang, Gaik W. Tew, Olga Li, Prescott G. Woodruff, Christopher E. Brightling, Michele Grimbaldeston, Stephanie A. Christenson, Mona Bafadhel, Carrie M. Rosenberger   +13 more
doaj   +1 more source

A targeted solution for estimating the cell-type composition of bulk samples

BMC Bioinformatics, 2021
Background To avoid false-positive findings and detect cell-type specific associations in methylation and transcription investigations with bulk samples, it is critical to know the proportions of the major cell-types.
Edwin J. C. G. van den Oord, Lin Y. Xie, Charles J. Tran, Min Zhao, Karolina A. Aberg   +4 more
doaj   +1 more source

Development of acoustically isolated extracellular plasma vesicles for biomarker discovery in allogeneic hematopoietic stem cell transplantation [Elektronisk resurs]

, 2021
Background: Infection and graft-versus-host disease (GvHD) are the major causes for mortality and morbidity of allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Scheding, Stefan,, Pálmason, Róbert,, Lim, Hooi Ching,, Soneji, Shamit,, Lund University., Lenhoff, Stig,, Laurell, Thomas,   +6 more
core   +1 more source

Tumor immune microenvironment and genomic evolution in a patient with metastatic triple negative breast cancer and a complete response to atezolizumab

Journal for ImmunoTherapy of Cancer, 2019
Background Metastatic TNBC (mTNBC) has a poor prognosis and few treatment options. The anti-PD-L1 antibody atezolizumab demonstrated clinical activity in mTNBC patients with PD-L1-positive tumor-infiltrating immune cells.
Luciana Molinero, Yijin Li, Ching-Wei Chang, Sophia Maund, Maureen Berg, Jeanne Harrison, Marcella Fassò, Carol O’Hear, Priti Hegde, Leisha A. Emens   +9 more
doaj   +1 more source

Quantitative Comparison of Conventional and t-SNE-guided Gating Analyses

Frontiers in Immunology, 2019
Dimensionality reduction using the t-Distributed Stochastic Neighbor Embedding (t-SNE) algorithm has emerged as a popular tool for visualizing high-parameter single-cell data.
Shadi Toghi Eshghi, Amelia Au-Yeung, Chikara Takahashi, Christopher R. Bolen, Maclean N. Nyachienga, Sean P. Lear, Cherie Green, W. Rodney Mathews, William E. O'Gorman   +8 more
doaj   +1 more source

Biomarkers of aging

Science China Life Sciences, 2023
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitations remain poorly characterized.
Bao, Hainan, Cao, Jiani, Chen, Mengting, Chen, Min, Chen, Wei, Chen, Xiao, Chen, Yanhao, Chen, Yu, Chen, Yutian, Chen, Zhiyang, Chhetri, Jagadish K., Ding, Yingjie, Feng, Junlin, Guo, Jun, Guo, Mengmeng, He, Chuting, Jia, Yujuan, Jiang, Haiping, Jing, Ying, Li, Dingfeng, Li, Jiaming, Li, Jingyi, Liang, Qinhao, Liang, Rui, Liu, Feng, Liu, Xiaoqian, Liu, Zuojun, Luo, Oscar Junhong, Lv, Jianwei, Ma, Jingyi, Mao, Kehang, Nie, Jiawei, Qiao, Xinhua, Sun, Xinpei, Tang, Xiaoqiang, Wang, Jianfang, Wang, Qiaoran, Wang, Siyuan, Wang, Xuan, Wang, Yaning, Wang, Yuhan, Wu, Rimo, Xia, Kai, Xiao, Fu-Hui, Xu, Lingyan, Xu, Yingying, Yan, Haoteng, Yang, Liang, Yang, Ruici, Yang, Yuanxin, Ying, Yilin, Zhang, Le, Zhang, Weiwei, Zhang, Wenwan, Zhang, Xing, Zhang, Zhuo, Zhou, Min, Zhou, Rui, Zhu, Qingchen, Zhu, Zhengmao, Cao, Feng, Cao, Zhongwei, Chan, Piu, Chen, Chang, Chen, Guobing, Chen, Hou-Zao, Chen, Jun, Ci, Weimin, Ding, Bi-Sen, Ding, Qiurong, Gao, Feng, Han, Jing-Dong J., Huang, Kai, Ju, Zhenyu, Kong, Qing-Peng, Li, Ji, Li, Jian, Li, Xin, Liu, Baohua, Liu, Feng, Liu, Lin, Liu, Qiang, Liu, Qiang, Liu, Xingguo, Liu, Yong, Luo, Xianghang, Ma, Shuai, Ma, Xinran, Mao, Zhiyong, Nie, Jing, Peng, Yaojin, Qu, Jing, Ren, Jie, Ren, Ruibao, Song, Moshi, Songyang, Zhou, Sun, Yi Eve, Sun, Yu, Tian, Mei, Wang, Shusen, Wang, Si, Wang, Xia, Wang, Xiaoning, Wang, Yan-Jiang, Wang, Yunfang, Wong, Catherine C. L., Xiang, Andy Peng, Xiao, Yichuan, Xie, Zhengwei, Xu, Daichao, Ye, Jing, Yue, Rui, Zhang, Cuntai, Zhang, Hongbo, Zhang, Liang, Zhang, Weiqi, Zhang, Yong, Zhang, Yun-Wu, Zhang, Zhuohua, Zhao, Tongbiao, Zhao, Yuzheng, Zhu, Dahai, Zou, Weiguo, Pei, Gang, Liu, Guang-Hui   +124 more
openaire   +2 more sources

Enhancing sepsis biomarker development: key considerations from public and private perspectives [PDF]

Implementation of biomarkers in sepsis and septic shock in emergency situations, remains highly challenging. This viewpoint arose from a public–private 3-day workshop aiming to facilitate the transition of sepsis biomarkers into clinical practice.
Rodriguez-Manzano, J, Rodriguez-Manzano, Jesus, Payen, D, Payen, Didier, on behalf of the Sepsis biomarker workshop group, Scicluna, Brendon P., Carrol, ED, Scicluna, BP, Llitjos, JF, François, B, Osuchowski, Marcin F., Carrol, Enitan D., Bonneville, Marc, François, Bruno, Witte, Stephan, Bonneville, M, Llitjos, Jean-Francois, Witte, S, Osuchowski, MF, Randolph, AG, Randolph, Adrienne G., Sepsis biomarker workshop group   +21 more
core   +1 more source

Immunologic Biomarkers and Biomarkers for Immunotherapies in Gastrointestinal Cancer [PDF]

Visceral Medicine, 2019
Gastrointestinal (GI) cancers contribute significantly to the worldwide cancer burden. Pathologic evaluation is indispensable for the estimation of prognosis and therapeutic strategy. At present, immunotherapies are evolving into efficient therapeutic approaches, which are accompanied by the need for biomarkers to predict therapy response.
Martin, Benedikt, Märkl, Bruno
openaire   +3 more sources

Toward a Topology-Based Therapeutic Design of Membrane Proteins: Validation of NaPi2b Topology in Live Ovarian Cancer Cells

Frontiers in Molecular Biosciences, 2022
NaPi2b is a sodium-dependent phosphate transporter that belongs to the SLC34 family of transporters which is mainly responsible for phosphate homeostasis in humans.
Leisan Bulatova, Daria Savenkova, Alsina Nurgalieva, Daria Reshetnikova, Arina Timonina, Vera Skripova, Mikhail Bogdanov, Mikhail Bogdanov, Ramziya Kiyamova   +8 more
doaj   +1 more source

Atezolizumab plus bevacizumab combination enables an unresectable hepatocellular carcinoma resectable and links immune exclusion and tumor dedifferentiation to acquired resistance

Experimental Hematology & Oncology, 2021
We reported a patient with unresectable hepatocellular carcinoma (HCC) who initially received 15 cycles of atezolizumab plus bevacizumab combination and had best tumor response of partial response, but later experienced disease progression.
Yulei Wang, Li-Chun Lu, Yinghui Guan, Ming-Chih Ho, Shan Lu, Jessica Spahn, Chih-Hung Hsu   +6 more
doaj   +1 more source