Results 11 to 20 of about 1,725,920 (355)

Development of a highly sensitive chemiluminescence immunoassay for quantification of aggrecanase-generated ARGS aggrecan fragments in serum

Osteoarthritis and Cartilage Open, 2021
Objective: Cartilage degradation is a hallmark of osteoarthritis (OA). Aggrecan, a major proteoglycan of articular cartilage extracellular matrix (ECM), is degraded by ADAMTS-5 resulting in the release of ARGS-G2 fragments to synovial fluid and ...
Yi He, Kamilla E. Jensen, Anne Sofie Siebuhr, Morten A. Karsdal, Jonathan Larkin, Anne C. Bay-Jensen   +5 more
doaj   +1 more source

Exploiting the noise: improving biomarkers with ensembles of data analysis methodologies. [PDF]

, 2012
BackgroundThe advent of personalized medicine requires robust, reproducible biomarkers that indicate which treatment will maximize therapeutic benefit while minimizing side effects and costs.
Boutros, Paul C, Der, Sandy D, John, Thomas, Jurisica, Igor, Lambin, Philippe, Pintilie, Melania, Shepherd, Frances A, Starmans, Maud Hw, Tsao, Ming-Sound   +8 more
core   +2 more sources

Anatomy of an extinction revealed by molecular fossils spanning OAE2

Scientific Reports, 2021
The Cenomanian–Turonian mass extinction (Oceanic Anoxic Event 2-OAE2) was a period of profound ecological change that is recorded in the sedimentary record in many locations around the globe.
R. M. Forkner, J. Dahl, A. Fildani, S. M. Barbanti, I. A. Yurchenko, J. M. Moldowan   +5 more
doaj   +1 more source

Effects of Rivaroxaban on Biomarkers of Coagulation and Inflammation: A Post Hoc Analysis of the X-VeRT Trial. [PDF]

, 2020
Introduction  This X-VeRT (eXplore the efficacy and safety of once-daily oral riVaroxaban for the prevention of caRdiovascular events in patients with nonvalvular aTrial fibrillation scheduled for cardioversion) substudy evaluated the effects of ...
Camm, AJ, Cappato, R, Ezekowitz, MD, Hohnloser, SH, Kirchhof, P, Meng, IL, Purmah, Y, Schiffer, S, Schulz, A, Wosnitza, M   +9 more
core   +1 more source

Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancer

Nature Communications, 2021
The emergence of acquired resistance to standard platinum-etoposide chemotherapy in small cell lung cancer (SCLC) is a common event. Here, the authors using paired pre-treatment and post-chemotherapy circulating tumour cell patient-derived explant (CDX ...
Maximilian W. Schenk, Sam Humphrey, A. S. Md Mukarram Hossain, Mitchell Revill, Sarah Pearsall, Alice Lallo, Stewart Brown, Samuel Bratt, Melanie Galvin, Tine Descamps, Cong Zhou, Simon P. Pearce, Lynsey Priest, Michelle Greenhalgh, Anshuman Chaturvedi, Alastair Kerr, Fiona Blackhall, Caroline Dive, Kristopher K. Frese   +18 more
doaj   +1 more source

Disease Knowledge Transfer across Neurodegenerative Diseases [PDF]

, 2019
We introduce Disease Knowledge Transfer (DKT), a novel technique for transferring biomarker information between related neurodegenerative diseases. DKT infers robust multimodal biomarker trajectories in rare neurodegenerative diseases even when only ...
Alexander, Daniel C., Blumberg, Stefano B., Crutch, Sebastian J., Eshaghi, Arman, Golland, Polina, Lorenzi, Marco, Marinescu, Razvan V., Morell, Pere P., Oxtoby, Neil P., Yong, Keir X., Young, Alexandra L.   +10 more
core   +4 more sources

Biomarkers for Sepsis [PDF]

BioMed Research International, 2014
Bloodstream infections are a major concern because of high levels of antibiotic consumption and of the increasing prevalence of antimicrobial resistance. Bacteraemia is identified in a small percentage of patients with signs and symptoms of sepsis. Biomarkers are widely used in clinical practice and they are useful for monitoring the infectious process.
Henriquez-Camacho, Cesar, Losa, Juan
openaire   +3 more sources

The Optimized Workflow for Sample Preparation in LC-MS/MS-Based Urine Proteomics

Methods and Protocols, 2019
The sample condition is an important factor in urine proteomics with stability and accuracy. However, a general protocol of urine protein preparation in mass spectrometry analysis has not yet been established.
Suguru Saito, Yoshitoshi Hirao, Ali F. Quadery, Bo Xu, Amr Elguoshy, Hidehiko Fujinaka, Shohei Koma, Keiko Yamamoto, Tadashi Yamamoto   +8 more
doaj   +1 more source

Quality assessment and interference detection in targeted mass spectrometry data using machine learning

Clinical Proteomics, 2018
Advances in the field of targeted proteomics and mass spectrometry have significantly improved assay sensitivity and multiplexing capacity. The high-throughput nature of targeted proteomics experiments has increased the rate of data production, which ...
Shadi Toghi Eshghi, Paul Auger, W. Rodney Mathews   +2 more
doaj   +1 more source

Biomarker reveals HIV's hidden reservoir. [PDF]

, 2014
Determining the total amount of HIV DNA in people undergoing antiretroviral therapy could accelerate the development of novel therapies and potential cures for HIV ...
Cockerham, Leslie R, Deeks, Steven G
core   +2 more sources