Results 231 to 240 of about 1,164,667 (298)

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

Real-world anti-amyloid therapy beyond traditional symptomatic populations: a longitudinal case series. [PDF]

Front Psychiatry
Han J, Fang Y, Esiaka D, Abraham O.
europepmc   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Plant-based dietary biomarkers: from discovery to validation using mass spectrometry-based metabolomics. [PDF]

Front Nutr
de Gier G, Balvers MGJ, Feskens EJM, Witkamp RF, Jermendi E.   +4 more
europepmc   +1 more source

Nationwide Survey of Association Between Fever and Epileptic Seizure in CDKL5 Deficiency Disorder Revealed Therapeutic Implications

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective CDKL5 deficiency disorder (CDD) is a rare, severe developmental and epileptic encephalopathy. There is a pressing need to develop effective and sustainable therapeutic strategies. We aimed to investigate the causal association between febrile episodes and epileptic seizures for therapeutic implications in CDD patients.
Siyi Wang, Jialin Du, Jinghui Liu, Dongmei Hu, Hongxin Wang, Xiaoxiao Man, Lehong Gao, Shimin Hu, Xianghong Meng, Hongyang Zhao, Minjing Hu, Yingxue Yang, Zhiqi Xiong, Liankun Ren   +13 more
wiley   +1 more source

Harmonizing biomarker testing in NSCLC: The critical role of cytopathology in delivering comprehensive biomarker testing for patients with NSCLC. [PDF]

Cancer Cytopathol
Roy-Chowdhuri S, Mani H.
europepmc   +1 more source

Peripheral blood biomarkers in PD-1/PD-L1 immunotherapy: distinguishing predictive from prognostic biomarkers. [PDF]

Front Immunol
Guo X, Wei Y, Miao Z, Ma S, Ma W.
europepmc   +1 more source

Impaired peptide amidation and risk of incident dementia in the Malmoe preventive project cohort. [PDF]

Alzheimers Res Ther
Kaufmann P, Ilina Y, Giontella A, Press M, Nägga K, Hansson O, Hampel H, Bergmann A, Melander O.   +8 more
europepmc   +1 more source

Key considerations when assessing clinical utility for biomarker testing: A checklist. [PDF]

J Manag Care Spec Pharm
Wang T, Tsai K, Kheloussi SS, McCormick D, Pawloski PA.   +4 more
europepmc   +1 more source