Results 251 to 260 of about 964,099 (295)

Reply to Letter: “Real‐World Clinical Experience With Serum MOG and AQP4 Antibody Testing by Live Versus Fixed Cell‐Based Assay”

Annals of Clinical and Translational Neurology, EarlyView.
Yana Said, Eoin P. Flanagan, Elias S. Sotirchos   +2 more
wiley   +1 more source

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

Advanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li, Sepehr Akhtarkhavari, Sumeng Qi, Jiawei Fan, Tu‐Yung Chang, Yao‐An Shen, JinMing Yang, Barbara S. Slusher, Ie‐Ming Shih, Stephanie Gaillard, Tian‐Li Wang   +10 more
wiley   +1 more source

Application of Biomarkers in Spinal Muscular Atrophy. [PDF]

Int J Mol Sci
Gao C, Zhan Y, Chen H, Deng C.
europepmc   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Correction to [Clinical features, biomarker profiles, and neuroimaging characteristics in patients from memory clinic in china: The Shanghai Memory Study]. [PDF]

Alzheimers Dement
europepmc   +1 more source

Performance of the neutrophil-to-lymphocyte ratio as a prognostic tool for survival in solid cancers. [PDF]

Front Oncol
Carrión-Barberà I, Lood C.
europepmc   +1 more source

Modelling Atherosclerotic Plaque Cap Mechanics: Microcalcifications Reduce Mechanical Properties in Mesenchymal Stromal Cell‐Based Model

Advanced Biology, EarlyView.
This study develops a tissue‐engineered model of the atherosclerotic cap using human mesenchymal stromal cells (MSCs). After 2 weeks of culture to produce a collagenous matrix, a mineralizing medium induces microcalcifications over 4 weeks. These constructs, imaged with second harmonic generation microscopy, lead to reduced ultimate stress at rupture ...
Imke L. Jansen, Deniz Şahin, Frank J.H. Gijsen, Eric Farrell, Kim van der Heiden   +4 more
wiley   +1 more source

Biomarker Testing Approaches, Treatment Selection, and Cost of Care Among Adults With Advanced Cancer.

JAMA Netw Open
DaCosta Byfield S, Bapat B, Becker L, Reyes C, Chatzitheofilou I, Schroeder BE, Hostin D, Fox J.   +7 more
europepmc   +1 more source

Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?

Advanced Biology, EarlyView.
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez, Hao Zhang, Dhananjay Sah, Juan P. Cata   +3 more
wiley   +1 more source