Results 21 to 30 of about 1,312,400 (160)
Journal of Stroke, 2013 Major stroke clinical trials have failed during the past decades. The failures suggest the presence of heterogeneity among stroke patients. Biomarkers refer to indicators found in the blood, other body fluids or tissues that predicts physiologic or disease states, increased disease risk, or pharmacologic responses to a therapeutic intervention.
Suk Jae Kim +2 more
openaire +3 more sources
Smell dysfunction: a biomarker for COVID‐19
International Forum of Allergy and Rhinology, 2020 Severe acute respiratory syndrome‐coronavirus‐2 (SARS‐CoV‐2), the virus that causes coronavirus disease 2019 (COVID‐19), is responsible for the largest pandemic since the 1918 influenza A virus subtype H1N1 influenza outbreak.
S. T. Moein +5 more
semanticscholar +1 more source
Nucleic Acids Res., 2012 Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The Genomics of Drug Sensitivity in Cancer (GDSC) database (www.cancerRxgene.org) is the largest public ...
Wanjuan Yang +16 more
semanticscholar +1 more source
Thorax, 2020 Large numbers of people are being discharged from hospital following COVID-19 without assessment of recovery. In 384 patients (mean age 59.9 years; 62% male) followed a median 54 days post discharge, 53% reported persistent breathlessness, 34% cough and ...
S. Mandal +15 more
semanticscholar +1 more source
miR-21: a non‐specific biomarker of all maladies
Biomarker Research, 2021 miRNA-21 is among the most abundant and highly conserved microRNAs (miRNAs) recognized. It is expressed in essentially all cells where it performs vital regulatory roles in health and disease.
A. Jenike, M. Halushka
semanticscholar +1 more source
Frontiers in Bioscience, 2010 Ageing is a complex process that negatively impacts the development of the different systems and its ability to function. On the other hand, the rate of ageing in humans is not uniform, due to genetic heterogeneity and the influence of environmental factors.
Vasto S. +11 more
openaire +6 more sources
British Journal of Cancer, 2008 Within the era of molecularly targeted anticancer agents, it has become increasingly important to provide proof of mechanism as early on as possible in the drug development cycle, especially in the clinic. Selective activation of apoptosis is often cited as one of the major goals of cancer chemotherapy.
Ward, T. H. +7 more
openaire +4 more sources
Clinical and biomarker changes in dominantly inherited Alzheimer's disease.
New England Journal of Medicine, 2012 BACKGROUND The order and magnitude of pathologic processes in Alzheimer's disease are not well understood, partly because the disease develops over many years.
R. Bateman +27 more
semanticscholar +1 more source
Patient-derived organoids as a predictive biomarker for treatment response in cancer patients
npj Precision Oncology, 2021 Effective predictive biomarkers are needed to enable personalized medicine and increase treatment efficacy and survival for cancer patients, thereby reducing toxic side effects and treatment costs.
G. Wensink +6 more
semanticscholar +1 more source
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction
Nature Network Boston, 2018 Vascular contributions to cognitive impairment are increasingly recognized1–5 as shown by neuropathological6,7, neuroimaging4,8–11, and cerebrospinal fluid biomarker4,12 studies.
D. Nation +18 more
semanticscholar +1 more source